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Endocrine Abstracts (2023) 90 EP913 | DOI: 10.1530/endoabs.90.EP913

1Faculty of Medicine, University of Banja Luka, Internal Medicine, Banja Luka, Bosnia and Herzegovina; 2University Clinical Centre of the Republika Srpska, Endocrinology, Banja Luka, Bosnia and Herzegovina; 3Faculty of medicine, University of Banja Luka, Nuclear Medicine, Banja Luka, Bosnia and Herzegovina; 4University of Belgrade - Faculty of Medicine, Endocrinology, Beograd, Serbia

Background: Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to androgen excess in these women. Therefore, the aim of the present study was to examine the association of adiponectin levels and androgens in women with PCOS.

Methods: A total of 60 women with PCOS who met the 2003 Rotterdam diagnostic criteria and 60 age and body mass index matched controls without PCOS were recruited. We determined anthropometric parameters, metabolic and endocrine indicators, serum adiponectin, and inflammatory markers, and statistically analyzed the results.

Results: PCOS women had significantly lower adiponectin level (P< 0.01) compared to healthy women. The adiponectin level correlated inversely with body mass index (BMI), waist circumference (WC), body fat mass, tryglicerides, homeostasis model assessment HOMA IR, AUCinsulin, AUCglucose, total testosterone, dehydroepiandrosterone sulfate (DHEAS) and free androgen index (FAI) and positively with sex hormone-binding globulin (SHBG) and high-density lipoprotein cholesterol (HDL) in the PCOS group. In multivariate logistic regression, BMI and FAI were significant independent determinants of adiponectin cut-off level of 7.7μg/ml.

Conclusions: In conclusion, our results confirm that adiponectin concentrations change according to variations of BMI in women with PCOS. They also suggest the role of androgen excess in obesity and adipose tissue dysfunction in PCOS women

Volume 90

25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

European Society of Endocrinology 

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