ECE2023 Eposter Presentations Reproductive and Developmental Endocrinology (48 abstracts)
Normative Range of 17-hydroxyprogesteroneamong Indian Reproductive Age Women
Mohd Ashraf Ganie 1 , Subhankar Chowdhury 2 , Vanita Suri 3 , Beena Joshi 4 , Prasanta Kumar Bhattacharya 5 , Sarita Agrawal 6 , Neena Malhotra 7 , rakesh sahay 8 , Puthiyaveettil Khadar Jabbar 9 , Roya Rozati 10 , Imtiyaz Ahmad Wani 11 , Taruna Arora 12 , Amlin Shukla 13 & Bharati Kulkarani 13
1Sher - i - Kashmir Institute of Medical Sciences, Department of Endocrinology & Clinical Research, Srinagar,; 2IPGME&R and SSKM Hospital, Department of Endocrinology & Metabolism, Kolkata, India; 3Post Graduate Institute of Medical Education & Research, Chandigarh, Department of Obstetrics & Gynaecology, Chandigarh, India; 4National Institute For Research In Reproductive and Child Health, Department of Operational Research, Mumbai, India; 5North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences, Department of Community Medicine, Shillong, India; 6All India Institute Of Medical Sciences, Raipur, Department of Obstetrics & Gynaecology, Raipur, India; 7, Department of Obstetrics & Gynaecology, New Delhi, India; 8Osmania Medical College, Department of Endocrinology, Hyderabad, India; 9Government Medical College Thiruvananthapuram, Department of Endocrinology, Thiruvananthapuram, India; 10Medical Health & Research Trust, Department of Obstetrics & Gynaecology, Hyderabad, India; 11Sher - i - Kashmir Institute of Medical Sciences, Department of Endocrinology & Clinical Research, Srinagar, India; 12Indian Council of Medical Research, Division of Reproductive Biology, Maternal & Child Health, New Delhi, India; 13Indian Council of Medical Research, Reproductive Biology and Maternal Health, New Delhi, India
Background: Non-classic adrenal hyperplasia (NCAH), comparatively a rare disease, is characterised by mild to moderate hyperandrogenemia, hirsutism, oligomenorrhea, insulin resistance which incidentally are the hallmarks of polycystic ovary syndrome (PCOS)- a common disorder among reproductive aged women. The data on 17-hydroxyprogesterone (17-OHP)serum levels in NCAH has been reported globally but there is limited data available regarding the normal range among healthy Indian reproductive age women.
Aim: We aimed to evaluate serum 17-OHP levels among healthy women of reproductive age from India as a reference range.
Materials and methods: A total of around 450women of reproductive age (18-40years) were recruited from different urban [n=226 (50.2%)]and rural[n=224 (49.8%)]regions of the country. The anthropometric, clinical and biochemical parameters were obtained using standard uniform questionnaire. The samples from all the subjects were collected during their follicular phase of menstrual cycle and assessment of 17-OHP was carried out using ELISA method (DiaMetra S.r.I., Segrate, Italy). The 95% of the reference distribution was estimated using 2.5th - 97.5thpercentile limits.
Results: The mean ±SD of age and body mass index (BMI) of participants was 30.12 ±6.32years and 22.8±3.36 kg/m2 respectively. The age of menarche for the subjects was reported to be 13.05±1.35years). The mean percentages of 17-OHP serum levels among recruited subjects were 0.49±0.259ng/ml with the median of 0.49ng/ml and range between 0.0059–2.0 ng/ml. The 2.5th - 97.5thpercentiles of 17-OHP among subjects at 2.5th; 5th; 10th; 25th; 50th; 75th; 90th; 95thand 97.5thwere reported as 0.09; 0.959; 0.15; 0.30; 0.65; 0.85; 0.81; 0.85 and 1.19 respectively.
Conclusion: This study is first of its kind to collect a data from a large representative sample of reproductive age Indian women. The data will serve as a reference range among healthy women of reproductive age.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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