Endocrine Abstracts

Background: The late effects of childhood cancer therapy include a higher risk of subsequent primary cancers, fertility issues, and other endocrine dysfunction.Case: A 47 year old woman was treated at age 9 for acute myeloid leukaemia with chemotherapy (DAT, MACE, and cyclophosphamide), total body irradiation (990 cGy) and allogeneic bone marrow transplantation. Aged 22, a rapidly enlarging right sided thyroid nodule developed in the context of a multino...

A17 years old male student was following pediatric clinic for short stature for about 5 years, investigated thoroughly for cortisol Growth hormone deficiency Gluten enteropathy but serum testosterone level was never done, growth hormone replacement was given for 18 months and then stopped, during history and complaint in his current visit his concerns was not short stature only but reduced libido and no hair growth in face and axilla.On examinati...

A 48 year old man was reviewed in the late endocrine effect of childhood cancer treatment clinic. He was diagnosed with Acute Lymphoblastic Leukemia back in 1983, at the age of 9 and underwent chemotherapy with UKALL X regime, craniospinal irradiation, followed by total body irradiation and autologous bone marrow transplant the same year. Subsequently he was found to be growth hormone deficient 2 years later and by the age of 21 he developed hypopituitarism. In 2001, by the ag...

Growth hormone replacement is not essential but it is an important treatment for adult with GH deficiency and for adults with childhood onset GH deficiency, the aim of management changes as they grow which involves testing and retesting, clarification of the replacement aim and adjustments of the dosage accordingly. This is a case of a 29 year old man who presented with short stature during childhood at the age 7 yr old and subsequently found to have growth hormone (GH) defici...

A 31 year old female presented to the Endocrine day ward due to headache and dizziness in 2015. She had a background of childhood acute lymphoblastic leukaemia diagnosed at age 7 treated with chemotherapy. She had a cerebral recurrence at age 10 and underwent cerebral radiotherapy, further chemotherapy and subsequently total body irradiation and bone marrow transplant. Following this treatment she was diagnosed with panhypopituitarism and required hormone replacement therapy w...

Sheehan is an Interesting disease; post-partum bleeding can cause dangerous pituitary gland necrosis. Sheehan’s syndrome is a well-known condition that is generally diagnosed several years postpartum or can present acutely. Hypopituitarism after diagnosis of Sheehan syndrome can be present in insidious ways and there may be delay to diagnosis of over a decade because symptoms are often vague and pituitary dysfunction progresses gradually. We presented the case of hypopitu...