Endocrine Abstracts

A 31-year-old gentleman presented to our Endocrine Services with his 20-year-old fiancée with plans for marriage and to conceive. He was diagnosed with congenital panhypopituitarism and absent pituitary stalk at the age of 4. He was started on replacement growth hormone, desmopressin, levothyroxine, hydrocortisone and testosterone, in this sequence, across the years. He underwent induction of puberty at the age of 13 years. He was noticed to have bilateral cryptorchidism ...

The relationship between male infertility and plasma testosterone level is not linear and sometimes there could be discordance in the association. This is a case of 41 year old investment banker presented with erectile dysfunction and low libido with intact morning erections referred to Endocrinology clinic after being seen by psychologist and private endocrinologist which started 3 years before for infertility. Puberty was early, normal, at around 9-10 years old age. Previous...

26-year-old referred with primary amenorrhea. Described puberty aged 11 years with breast and axillary hair development. One day of a menstrual period in secondary school. She has a partner and would like to start a family.PMHT2DM on metformin and liraglutide Undiagnosed but possible learning disability/ autism Increased BMI, 57.5 kg/m2ExaminationIncrea...

Background: Hypogonadotropic hypogonadism (HH) is one of the few treatable causes of male infertility; spermatogenesis induction can be achieved with gonadotrophins or pulsatile GnRH. Treatment protocols are normally long, and outcome varies according to the underlying aetiology, age of onset and history of undescended testes. Regular follow-ups are needed to assess the response and monitor for adverse effects of therapy that could make the management challenging.<p class=...

A 36 M seen in endocrinology clinic October 2022 with 9/12 history of reduced testicular size and hypo gonadal symptoms. He has a past medical history of suicidal ideation and urinary incontinence. On review of previous GP records from 2003 he was seen for delayed puberty, although the patient denied this in clinic. There was no history of testicular trauma or infection and he denied any history of exogenous steroid or recreational drug use. There was no significant family his...

A 45-year-old Caucasian man with BMI of 34 presented with a few years’ history of low libido and premature ejaculation. He had azoospermia in the past for infertility investigation 4 years ago with his previous relationship. His LH and FSH were high at 18 U/l(2-13 U/l) and 10 U/l(2-9 U/l) while his 9 amtestosterone level was 19.2 nmol/l(10-38 nmol/l) along with normal prolactin and TSH. The testicular examination is unremarkable. His repeat semen analysis shows azoospermi...

A 36 year old man was referred to the Endocrine clinic from his GP practice due to an incidental finding of high Testosterone (44.3 nmol/l). He is an actor who has been under a private Trichologist for a number of years, and had been on Finasteride and topical Mixonidil. Under the Trichologist he has had his Testosterone levels periodically monitored, which had been persistently elevated since at least 2018 (39-44 nmol/l). The patient was otherwise well. He has Type 1 Diabetes...

Introduction: Infertility is a common medical condition affecting 50 million couples worldwide and azoospermia account for around 10 % of cases of male infertility. Non-obstructive azoospermia is one of the most severe forms of male infertility and aetiology could be due to primary testicular failure, secondary testicular failure and those with incomplete or ambiguous picture of testicular failure.Case report: A 34-year-old patient referred to endocrine ...