Endocrine Abstracts

Introduction: Neonatal screening for congenital hypothyroidism is considered a major cornerstone in making early diagnosis and starting therapy in neonates. This is a very important step to prevent the consequences of untreated hypothyroidism including mental retardation and developmental delay. Neonatal screening is usually conducted by screening the level of T4 with or without TSH level. Confirming the diagnosis of hypothyroidism is a very important step before starting ther...

Introduction: Turner syndrome (TS) is a chromosomal disorder affecting female and characterized by complete or partial monosomy of the X chromosome. These genetic changes lead to the abnormalities in growth and development and increase the risk of autoimmune diseases, including those affecting the thyroid. Thyroid pathology in TS may include autoimmune thyroiditis, hypothyroidism, thyrotoxicosis (Graves disease, AIT in the hyperthyroid state). Thyrotoxicosis is the clinical sy...

Background: Struma ovarii is a germ cell tumor of the ovary containing ≥ 50% thyroid tissue and malignant struma ovarii (MSO) is a very rare disease containing papillary or follicular thyroid carcinomas (FTC). There is no consensus on optimal management for patients with MSO and no data on radioactive iodine (RAI) responsiveness. Here, we report two cases with RAI refractory MSO with NRAS mutation detected by next-generation sequencing (NGS). Case ...

Introduction: In the spectrum of endocrine emergencies, thyroid storm is one of the most critical complications. Recognition and appropriate management of life-threatening thyrotoxicosis is vital to prevent the high morbidity and mortality that may accompany this disorder. The incidence of thyroid storm has been noted to be less than 10% of patients hospitalized for thyrotoxicosis; however, the mortality rate secondary to thyroid storm ranges from 20 to 30%. We report in this ...

A male patient, currently 64 years old, was diagnosed with TED (Thyroid Eye Disease) in 1993 when he underwent surgery for “exophthalmos” in both eyes (likely decompression surgery), followed by surgery to correct diplopia. He underwent a total thyroidectomy one year later. For ongoing “activity” of thyroid and TED patient received radioiodine ablation in 1995 and 1997. At that time, he also received “some pulses” of methylprednisolone and long-te...

Introduction: The thyroid gland is affected by amyloidosis in 50% of cases in primary amyloidosis and80% in secondary amyloidosis.Case report: The patient, male, born in 1976 was admitted to the department of endocin Surguary of the Astghik Medical Center, Armenia complaining of general weakness, feeling of compression and heaviness in the neck (cervical discomfort), cough, shortness of breath, swallowing difficulty. When the patient was 12 years old dia...

Mucoepidermoid carcinomas (MECs) are the most common malignant tumors of the salivary glands. Primary thyroid MECs are extremely rare (about 0.5% of all thyroid malignancies) and, in the majority of cases, are associated with an indolent biologic potential and excellent long-term prognosis. We present the case of a 67-year-old man, with a recently growing anterior cervical mass, associating dyspnoea and fatigue. Thyroid ultrasound revealed an inhomogeneous, hypoechoic mass in ...

Introduction: Hypokalemic periodic paralysis (HPP) belongs to a group of inherited diseases called channelopathies, whose main manifestation include painless muscle paralysis. There are also acquired forms of HPP secondary to hyperthyroidism, called thyrotoxic periodic paralysis (TPP). It’s prevalence is markedly higher in men.Case Reports: Case 1. 34-year-old Venenzuelan man, without medical history. He consults in the emergency de...

Thyrotoxicosis causing hypokalaemic paralysis is a known complication among Asians, Myopathy as a result of thyrotoxicosis or caused by antithyroid drugs (ATD) is rare. Myositis, resulting in a rise in creatinine kinase levels (CK) is commonly seen in overt hypothyroidism, however, rapid lowering in circulating thyroid hormone levels during the treatment of Graves’ disease could result in myalgia and elevated CK levels. This complication needs to be actively diagnosed whe...