Searchable abstracts of presentations at key conferences in endocrinology
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45th Annual Meeting of the European Thyroid Association (ETA) 2023

ea0092ps3-23-01 | Pregnancy | ETA2023

TSH elevation before or after a pregnancy according to unidentified maternal thyroid function and thyroid autoantibody status in the early pregnancy: A study of 13,664 danish pregnant women

Linding Andersen Stine , Hjelm Lundgaard Maja , Maria Uldall Torp Nanna , Lykkeboe Simon , Carle Allan , Karmisholt Jesper , Bulow Pedersen Inge , Vestergaard Peter , Andersen Stig

Objectives: One of the risk-based screening criteria for thyroid disease in pregnancy is previous abnormal thyroid function or thyroid autoantibody-positivity. We speculated on the frequency and results of thyroid function testing in women of fertile age as part of routine care before and after a pregnancy.Methods: The North Denmark Region Pregnancy Cohort includes retrospective assessment of thyroid function and thyroid autoantibodies (ADVIA Centaur XPT...

ea0092ps3-23-02 | Pregnancy | ETA2023

B cells from anti-thyroid antibody positive, infertile women show hyper-reactivity to BCR stimulation

Bajnok Anna , Sereny-Litvai Timea , Temesfoi Viktoria , Norenberg Jasper , Pham-Dobor Greta , Kaposi Ambrus , Varnagy Akos , Kovacs Kalman , Pentek Sandor , Koszegi Tamas , Berki Timea , Mezosi Emese

Anti-thyroid antibody (ATA) positivity affects 1 out of 9 women in childbearing age and presents a significant risk for infertility. Emerging evidence indicates that alterations in the B cell receptor induced calcium (Ca2+) signaling could be key in the development of autoimmunity. We aimed to investigate the Ca2+ flux response of B lymphocyte subsets to BCR stimulation in Hashimoto’s thyroiditis and related infertility. We collected peripheral blood samples from ATA+, in...

ea0092ps3-23-03 | Pregnancy | ETA2023

Prevalence of postpartum worsening of graves’ orbitopathy in relation to thyroid dysfunction in patients with graves’ disease in japan

Suzuki Nami , Watanabe Natsuko , Jaeduk Yoshimura Noh , Yoshihara Ai , Fukushita Miho , Matsumoto Masako , Hiruma Shigenori , Imal Hideyuki , Sugino Kiminori , Ito Koichi , Kozaki Ai , Inoue Tosyu

Background: Graves’ hyperthyroidism is known to improve spontaneously during pregnancy due to immune tolerance, although postpartum worsening or relapse of hyperthyroidism is likely to occur.Objective: To investigate the prevalence of postpartum worsening of Graves’ orbitopathy (GO) in relation to thyroid dysfunction.Methods: This was a retrospective cross-sectional study that included 8594 patients with Graves’ dise...

ea0092ps3-23-04 | Pregnancy | ETA2023

Physical development, neuropsychological health and quality of life in a group of adult subjects with congenital hypothyroidism early treated with levothyroxine after newborn screening

Pignata Luisa , De Marco Giuseppina , Ferrarini Eleonora , Agretti Patrizia , Di Cosmo Caterina , Bagattini Brunella , Sciarroni Elisabetta , Tonacchera Massimo , Bargagna Stefania , Montanelli Lucia

Background: The introduction of newborn screening for congenital hypothyroidism (CH) has led to prevent the most serious consequences of precocious deficit of thyroid hormone during child development, particularly neurological disability. However, little is known about long-term physical and psycho-social outcomes of CH after screening introduction.Objective: To evaluate physical and neuropsychological development and Quality of Life (QoL) in adult subje...

ea0092ps3-23-05 | Pregnancy | ETA2023

Iodine nutritional status and related thyroid function in pregnancy: A results of a prospective study conducted in a large group of women

Sciarroni Elisabetta , Orsolini Francesca , Gianetti Elena , Montanelli Lucia , Bagattini Brunella , Fiore Emilio , Tonacchera Massimo

Background and Objectives: During pregnancy normal thyroid activity undergoes significant changes, including an increase in the amount of iodine intake and maternal renal iodine excretion. Hence, dietary iodine requirements are higher in pregnant women than in non-pregnant ones. This study aimed to assess the nutritional iodine status in a large group of pregnant women and thyroid function according to different iodine intake and thyroid diseases.Methods...

ea0092ps3-23-06 | Pregnancy | ETA2023

Iodine nutrition in italian pregnant women: preliminary results of a multicenter study

De Angelis Simona , Rotondi Daniela , Bagnasco Marcello , Boi Francesco , Bonofiglio Daniela , Mariotti Stefano , Mian Caterina , Moleti Mariacarla , laura Tanda Maria , Tonacchera Massimo , Vermiglio Francesco , Ulisse Salvatore , Medda Emanuela , Sorbo Angela , D'Amato Marilena , Chiara Turco Anna , Ferrarini Eleonora , De Marco Giuseppina , Russo Giampiero , Morelli Michele , Sanna Stefania , Corongiu Margherita , Musso Laura , Giovanna Perdichizzi Laura , Olivieri Antonella

Background and objectives: Recent data on median urinary iodine concentration (UIC) in schoolchildren showed that Italy has achieved iodine sufficiency. Nevertheless, no national data on iodine nutrition in pregnancy are available. Therefore, a multicentre study coordinated by the Italian National Observatory for Monitoring Iodine Prophylaxis (OSNAMI), was launched in 8 Italian regions representative of the Northern (Lombardy, Veneto, Liguria), Central (Tuscany, Lazio) and Sou...

ea0092ps3-23-07 | Pregnancy | ETA2023

Effect of selenium supplementation on carbohydrate metabolism in hungarian patients with and without pregnancy

Molnar Jeannette

In the last 20 years an increasing number of European patients with autoimmune thyroiditis are supplemented with selenium in case of elevated thyroid autoantibody levels. However, a multicenter research trial in the United States suggested that selenium supplementation might increase the incidence of type 2 diabetes. The aim of this small study was to assess whether selenium supplementation in patients with autoimmune thyroiditis has any effect on carbohydrate metabolism witho...

ea0092ps3-23-08 | Pregnancy | ETA2023

The thyroid status of patients with gestationnal diabetes

Brakni Lila

Introduction: Pregnancy is a test for the thyroid, which has many physiological adaptation mechanisms to increased hormonal needs and iodine depletion. These changes expose the pregnant woman to dysthyroidism not devoid of maternal and fetal consequences. The prevalence of clinical and subclinical thyroid insufficiency in pregnant women are 0.3 to 0.7% and 2.2 to 2.5%, respectively. The objective of this study is to evaluate the thyroid status in a population of diabetic pregn...

ea0092ps3-23-09 | Pregnancy | ETA2023

Clinical impact of the thyroid hormone measure and the reference intervals in critically ill pregnant women

Motta Miriam , Di Sarli Yone , Silveira Letycia , Monteiro de Sousa Beatriz , Harumy Hirata Andrea , Pinto Camacho Cleber

Thyroid hormones measure is inevitable in some critically ill patients and may help the management. Alternatively, the physiological changes in the thyroid imbalance during pregnancy also make establishing reference intervals for critical ill challenging.Objectives: We aimed to compare reference intervals in an obstetric intensive care unit.Methods: After excluding patients admitted after delivery or pregnant under thyroid disease ...