Endocrine Abstracts

Introduction: Two-thirds of metastatic differentiated thyroid cancer (DTC) patients have RAI-resistant disease, resulting in poor prognosis and high disease-related mortality. Current studies of individualized therapy with different MAPK inhibitors report restoring RAI-avidity in 50 – 70% of BRAF and RAS mutated and thyroid cancers with no detected driver mutation. Five recent case reports of rare NTRK and RET-PTC fusion-positive metast...

Objectives: Attempts have been made to identify markers for aggressive disease in papillary microcarcinomas (PMCs), but genetic alterations identified in PMCs have failed to distinguish tumors with high-risk features. Thus, we aimed to identify candidate markers associated with lateral node metastasis (N1b) in patients with PMC through a transcriptomic analysis.Methods: Bulk RNA sequencing was performed in 26 matched tumor and normal thyroid tissue sampl...

The objectives: To evaluate the diagnostic efficiency of the HBME-1 expression test on cytological samples with Bethesda categories III, IV, and V in the differential diagnosis of thyroid nodular lesions.Materials and methods: The data of 14 patients with thyroid nodular lesions and cytological Bethesda categories III, IV, and V (" gray zone ") were analyzed. The HBME-1 expression was determined by the results of immunocytochemical (IC) and immun...

Introduction: The prevalence of B-type Raf kinase (BRAFV600E) mutation in PTC has been observed in 30% to over 80%, and it seems that the mutation occurred in the early stage of thyroid carcinoma progression which precedes histological change. Based on previous reports, high body mass index (BMI) is considered a thyroid cancer risk. However, it is unclear whether high BMI has a certain association with the BRAFV600E mutational status. We assess whether high BMI is associated w...

Background: Telomerase reverse transcriptase (TERT) promoter mutation is a poor prognostic factor in differentiated thyroid carcinoma(DTC). It is thought to play a role in the transformation process to undifferentiated thyroid carcinoma(UTC), but its role as a prognostic factor in UTC is unclear. Therefore, in this study, we investigated whether the TERT promoter mutation acts as as an independent poor prognostic factor in UTC.Methods: Among patients dia...

Introduction: Ultrasound-guided fine-needle aspiration cytology (US-FNAC), the gold standard method to distinguish benign from malignant thyroid nodules, is the most accurate, cost-effective and minimal invasive preoperative test, aiming to resolve patient management. However, up to 30% of US-FNACs are classified as indeterminate nodules, making difficult to avoid unnecessary surgeries. Molecular tests may contribute to refine the preoperative diagnosis of thyroid nodules....

Introduction and Objective: Thyroid cancer (TC) is the most common endocrine tumor with a growing incidence worldwide. However, diagnostics using ultrasound research methods do not allow to unambiguously determine the type of thyroid lesion and make a precise diagnosis in early stages. The results of recent studies indicate the metabolic changes occurring in cancer cells. Various molecular biomarkers and indices (TYG, TYG-BMI) may indicate the onset of development and progress...

Introduction: Several studies recommend the use of molecular tests for a complete diagnosis of malignancy in thyroid carcinomas (TC). The study and identification of molecular markers in thyroid will contribute to a personalized and effective treatment of the patients. The development of TC has been associated with the activation of oncogenes that are implicated in the cell signaling pathway, interfering in cancer promotion and outcome. Moreover, the repertoire of microRNAs (m...

Objectives: The substitution BRAF p.V600E is the most common genetic cause of the papillary thyroid carcinoma (PTC) and represents more than 95% genetic variants in BRAF gene. Other rare variants in the BRAF gene include other substitutions (e.g. p.K601E), small deletions or insertions close to codon 600. The aim of this study was to analyze a large cohort of thyroid nodules for rare genetic variants in the BRAF gene.M...