ETA2023 Poster Presentations Hypothyroidism (9 abstracts)
Efficacy of oral liquid l-thyroxine (L-T4) in controlling hypothyroidism in patients submitted to total thyroidectomy
Francesca Ragusa 1 , Poupak Fallahi 2 , Silvia Martina Ferrari 3 , Giusy Elia 1 , Gabriele Materazzi 4 , Sabrina Rosaria Paparo 2 , Armando Patrizio 5 , Valeria Mazzi 1 , Paolo Miccoli 1 & Alessandro Antonelli 1
1University of Pisa, Department of Surgical, Medical and Molecular Pathology and Critical Area, Pisa, Italy; 2University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa, Italy; 3University of Pisa, Department of Clinical and Experimental Medicine, Pisa, Italy; 4Unità DI Endocrinologia, Dipartimento DI Medicina Clinica e Sperimentale, Università DI Pisa, Pisa, Italia, University of Pisa, Department of Surgical, Medical, Molecular Pathology and Critical Area, Italy; 5Azienda Ospedaliero-Universitaria Pisana, Department of Emergency Medicine, Pisa, Italy
Tablet levothyroxine (L-T4) is the common treatment for hypothyroidism. We aim to investigate the efficacy of L-T4 in liquid formulation in patients recently subjected to total thyroidectomy (without malabsorption or drug interference), with respect to L-T4 tablets. Eighty patients were treated with L-T4 in tablets, whereas one hundred and sixty received liquid L-T4 at the same dosage (1.5 mg/kg/day). All patients started the therapy the day after thyroidectomy, and the drugs were assumed every day 30 min before breakfast. Serum thyrotropic hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were evaluated in a first control after 6 weeks, then in a second control after 12 weeks. We showed a significantly higher prevalence of patients in the hypothyroid range (TSH>3.6 mcU/ml) under a L-T4 tablet therapy, with respect to those in treatment with the L-T4 liquid formulation. Furthermore, TSH values were significantly lower in the liquid L-T4 group, than in the tablet L-T4 group both at the first (P < 0.05), and at the second control (P < 0.01). FT4 and FT3 levels were not significantly different. Our results suggest that liquid L-T4 therapy leads to a better control of TSH levels in thyroidectomized patients, not reporting issues of malabsorption, gastric disorders, or drug interference.
Keywords: Hypothyroidism, total thyroidectomy, liquid L-T4, tablet L-T4, Hormone Replacement Therapy, Thyroid
Volume 92
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Endocrine Abstracts
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