ETA2023 Poster Presentations Thyroid hormone diagnostics 2 (9 abstracts)
Diagnostic performance of 18F-choline PET/CT for detection of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: a single-center experience
Jung Heo 1 , Hyunju Park 2 , Tae Hyuk Kim 3 , Jae Hoon Chung 3 , Sun Wook Kim 3 , Heera Yang 3 , Jee Soo Kim 4 , Jun Ho Choe 4 , Jung Han Kim 4 , Young Seok Cho 5 & Joon Young Choi 5
1Wonju Severance Christian Hospital, Division of Endocrinology and Metabolism, Department of Internal Medicine, Wonju, Korea, Rep. of South; 2Cha Bundang Medical Center, Department of Internal Medicine, Seongnam, Korea, Rep. of South; 3Samsung Medical Center, Division of Endocrinology and Metabolism, Department of Medicine, Seoul, Korea, Rep. of South; 4Samsung Medical Center, Department of Surgery, Seoul, Korea, Rep. of South; 5Samsung Medical Center, Department of Nuclear Medicine, Seoul, Korea, Rep. of South
Objectives: 18F-choline PET/CT is a recently introduced imaging modality to localize hyperfunctioning parathyroid glands in patient with hyperparathyroidism. But there has been no study according the diagnostic power of 18F-choline PET/CT in Korea so far owing to its limited distribution. Therefore, we evaluated the diagnostic performance of 18F-choline PET/CT in detection of hyperfunctioning parathyroid gland in patients with primary hyperparathyroidism.
Methods: Fifty patients with primary hyperthyroidism who underwent 18F-choline PET/CT before parathyroidectomy between July 2020 and October 2022 at Samsung Medical Center were included. Lesion-based analysis was performed. The diagnostic performance of 18F-choline PET/CT in all patients and in patient with inconclusive results of ultrasonography and 99mTc-MIBI SPECT/CT were evaluated comprehensively. Data included demographics, laboratory findings, image findings and pathologic reports.
Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy 18F-choline PET/CT in all patients included were 100%, 99.3%, 98%, 100% and 99.5%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18F-choline PET/CT in 12 patients with inconclusive ultrasonography and 99mTc-MIBI SPECT/CT results were 100%, 97.2%, 92.3%, 100% and 97.9% respectively.
Conclusion: 18F-choline PET/CT showed superior diagnostic performance to conventional modalities in both main analyses and subgroup analyses of inconclusive ultrasonography and 99mTc-MIBI SPECT/CT. False-positive result was observed only in a patient. 18F-choline PET/CT could be considered as a first-line modality in localizing hyperfunctioning parathyroid glands in primary hyperparathyroidism.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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