Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 93 | EYES2023 | Next issue

ESE Young Endocrinologists and Scientists (EYES) 2023

ESE Young Endocrinologists and Scientists (EYES) 2023

Oral communication 5: Reproductive Endocrinology

ea0093oc30 | Oral communication 5: Reproductive Endocrinology | EYES2023

Quantification of 27 sex hormones, precursors and metabolites thereof in human plasma by a mass spectrometry-based method combining direct detection and specific hydrolysis of glucuronide conjugates

Raps Miriam , Kleider Carolin , Pemp Daniela , Lehmann Leane

Background: Steroid hormones such as the estrogen 17β-estradiol and the androgen testosterone play an important role in the etiology of hormone dependent diseases. To investigate factors influencing endogenous steroid hormone synthesis also biologically less active glucuronides and sulfates should be considered since they can serve as circulating reservoir for bioactive hormones. As the sensitivity of the available mass spectrometry (MS)-based method is lower for glucuron...

ea0093oc31 | Oral communication 5: Reproductive Endocrinology | EYES2023

Luteinizing hormone/choriogonadotropin receptor (LHCGR)/G protein-coupled estrogen receptor (GPER) heteromers impact on reproductive signals

Lazzaretti Clara , Paradiso Elia , Sperduti Samantha , Sayers Niamh , Pelagatti Ginevra , D'Alessandro Sara , Perri Carmela , Baschieri Lara , Simoni Manuela , Hanyaloglu Aylin Carla , Casarini Livio

Background: Follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) are expressed on the surface of granulosa cells, where they form heteromeric complexes, shifting FSH-induced signals to survival pathways and determining the follicular fate.Objectives: We evaluated whether GPER can interact with the luteinizing hormone (LH)/choriogonadotropin (hCG) receptor (LHCGR) and modulate the LH/hCG/dependent signalling pathways...

ea0093oc32 | Oral communication 5: Reproductive Endocrinology | EYES2023

Follicle stimulating hormone in male idiopathic infertility: How to predict its efficacy?

Romeo Marilina , Spaggiari Giorgia , Valentina Leonardo Dalla , Nuzzo Federico , Roli Laura , Santis Maria Cristina De , Trenti Tommaso , Granata Antonio R. M. , Simoni Manuela , Santi Daniele

Background: Testis stimulation with follicle stimulating hormone (FSH) is one of the empirical treatments proposed for male idiopathic infertility, although early reliable markers to predict its efficacy are still lacking.Objective: To identify the improvement of semen parameters required to predict a priori FSH efficacy in terms of pregnancy achievement.Methods: A real-world study was conducted, enrolling idiopathic infer...

ea0093oc33 | Oral communication 5: Reproductive Endocrinology | EYES2023

Variants in the neurodevelopmental gene bone morphogenic protein/retinoic acid inducible neural-specific 2 (BRINP2) are associated with severe delayed puberty

Al-Sayed Yasmin

Gonadotropin-releasing hormone (GnRH) is the master hormone regulating the reproductive axis and its pulsatile secretion is crucial for puberty onset and fertility. Disruption in GnRH neuron development or hypothalamic function can lead to absent or delayed puberty (DP), with a phenotypic spectrum from severe DP to partial or complete Hypogonadotropic Hypogonadism (HH). We aimed to identify novel genetic etiology of severe DP by screening and identifying variants in associated...

ea0093oc34 | Oral communication 5: Reproductive Endocrinology | EYES2023

Testosterone serum levels in idiopathic male infertility: An epidemiological insight with pathophysiological and clinical consequences

Costantino Francesco , Spaggiari Giorgia , Valentina Leonardo Dalla , Romeo Marilina , Roli Laura , De Santis Maria Cristina , Trenti Tommaso , Granata Antonio , Simoni Manuela , Santi Daniele

Background: Despite male idiopathic infertility is characterized by semen analysis alteration with gonadotropins within reference ranges, it is still considered a functional hypogonadotropic hypogonadism (FHH). This simple definition is fundamental to guide the empirical therapeutic approach of these men. However, the number of studies describing total testosterone serum levels (TT) in male idiopathic infertility is still limited.Objective: To evaluate T...

ea0093oc35 | Oral communication 5: Reproductive Endocrinology | EYES2023

Alteration of adrenal and sex steroid profiles in pregnant women with preeclampsia

Trummer Olivia , Stern Christina , Reintar Sharmaine , Tandl Veronika , Mayer-Pickel Karoline , Cervar-Zivkovic Mila , Fassnacht Martin , Kurlbaum Max , Huppertz Berthold , Fluhr Herbert , Obermayer-Pietsch Barbara

Background: Preeclampsia (PE) is a serious and complex pregnancy-related condition, characterized by hypertension and endothelial dysfunction, which can potentially damage liver, brain and kidneys, resulting to an increased perinatal morbidity and mortality. We investigated pregnancy-related steroid hormones such as progestogens, estrogens, androgens, and glucocorticoids to assess maternal and fetal development. We aim to compare steroid hormone profiles throughout pregnancy, ...

ea0093oc36 | Oral communication 5: Reproductive Endocrinology | EYES2023

Evolution of cardiovascular risk markers in polycystic ovary syndrome: Results from a long-term monocentric cohort study

Cecchetti Carolina , Pandurevic Srdjan , Dionese Paola , Belardinelli Elisabetta , Rotolo Laura , Fanelli Flaminia , Bergamaschi Luca , Pizzi Carmine , Pagotto Uberto , Gambineri Alessandra

Background: Many questions concerning polycystic ovary syndrome (PCOS) remain unsolved, such as the long-term evolution of cardiovascular (CV) risk markers and the risk for CV events.Methods: A total of 119 PCOS patients diagnosed in 2009 by NIH criteria at our Unit were evaluated at baseline for cardiovascular risk markers (hypertension, diabetes mellitus-DM, dyslipidaemia, obesity, carotid intima media thickness-cIMT, and epicardial fat thickness-EFT) ...

ea0093oc37 | Oral communication 5: Reproductive Endocrinology | EYES2023

Regulation of the postnatal activity of the HPG axis in male Callithrix jacchus – A project description

Odroniec Amadeusz , Busch Alexander

Background: The control of the Hypothalamic–Pituitary–Gonadal (HPG) axis is a highly complex process, with the hypothalamic arcuate-median eminence complex (Arc-ME) as the master regulating region. The transient activation of the HPG axis is essential for the development and function of the reproductive system. This project’s focus is the transient phase of HPG axis activation within the first weeks and months postpartum (minipuberty). The mechanisms guiding the...

ea0093oc38 | Oral communication 5: Reproductive Endocrinology | EYES2023

Body composition in association with serum anti-Müllerian hormone (AMH) levels in adult males implies hemodilution effects

Tandl Veronika , Haudum Christoph , Eberhard Katharina , Hutz Barbara , Foessl Ines , Kolesnik Ewald , Zirlik Andreas , von Lewinski Dirk , Scherr Daniel , Verheyen Nicolas , Pieber Thomas , Obermayer-Pietsch Barbara

Background: A negative relationship between body mass index (BMI) and serum Anti-Müllerian hormone (AMH) levels has been previously reported. Whether this is because of an adverse effect of adiposity on AMH production or the hormone’s dilution in a higher blood volume that accompanies larger body size (‘hemodilution’) is not yet clear. Blood volume can be estimated by body weight, body surface area (BSA) or lean mass (LM). Of note, adipose tissue is poorly ...