Endocrine Abstracts

Background: Thyroid hormone (TH) action is mediated by TH receptors (TRs) α&β. Both regulate gene expression by binding TREs on the DNA (canonical signaling) or activate cellular signaling pathways (noncanonical signaling). Bone is a major TH target and noncanonical TR α & β effects on bone metabolism were suggested. We studied mouse model bones to distinguish between signaling types.Methods: Growth of WT mice and mice with ei...

Introduction: Pregnancy-related osteoporosis represents a very rare pathology, which manifests through fractures that appear during pregnancy or early postpartum in patients who didn’t have related risk factors prior to the pregnancy. Due to the low number of cases reported, this pathology raises problems regarding diagnosis, etiology and the optimal treatment scheme, as we are going to illustrate through the following case. The etiology of this pathology is unknown &#150...

Objectives: to study the response of calcium and phosphate homeostasis parameters to the cholecalciferol loading dose in patients with predialysis chronic kidney disease (CKD). Methods: We examined 17 patients with stage 3 CKD (CKD3) and 9 patients with stages 4–5 CKD (CKD4-5) without previously known disorders of mineral metabolism and intake of interfering drugs during last 3 months. The assessments included serum 25-hydroxyvitamin D (25(OH)D), free 25...

Background: Moderate hypophosphatemia is not an uncommon finding. As usually requiring no specific intervention, it might be neglected and serum phosphate measurements are sometimes skipped. Only 1% of phosphorus is in extracellular fluid so it is not a reliable marker of body phosphorus reserve and refractory chronic hypophosphatemia might be a sign of severe phosphorus depletion.Case presentation: A fifty-two-year-old male patient presented with a 12-m...