Searchable abstracts of presentations at key conferences in endocrinology
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ESE Young Endocrinologists and Scientists (EYES) 2023

Poster Presentations

Guided Poster Tour 1: Adrenal and Neuroendocrine tumors

ea0093p1 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

Proposition of an histopathological classification of bilateral macronodular adrenal disease (BMAD) and its correlation with ARMC5 and KDM1A mutations

Violon Florian , Bouys Lucas , Berthon Annabel , Bruno Ragazzon , Barrat Maxime , Terris Benoit , Bertherat Jerome , Sibony Mathilde

Introduction: Bilateral macronodular adrenal disease (BMAD, former PBMAH) is a rare cause of Cushing’s syndrome. The few morphologic descriptions of BMAD mention multinodular hyperplastic adrenal glands composed of clear spongiocytic cells and fewer compact eosinophilic cells without any morphologic variation. The discovery of ARMC5 and KDM1A mutations argues for genetic heterogeneity. The aim of this work was to describe the morphological and immunohist...

ea0093p2 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

Assessment of the hypothalamus–pituitary–adrenal axis in patients following adrenalectomy

Taylor Sabrina , Gao Hao , Shekhda Kalyan , Karra Efthimia , Armeni Eleni

Background: Resection of the adrenal gland is a challenging intervention that requires close endocrinological supervision for the correct assessment of hormones to minimise complications peri-operatively (peri-op) and post-operatively (post-op).Objectives: This study assessed the function of the hypothalamus–pituitary–adrenal axis and the related management according to underlying adrenal disorders.Methods: We reviewed 16...

ea0093p3 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

MEN 2 syndrome heterogeneity in a cohort of Romanian patients

Manole Tiberiu , Baciu Ionela , Galoiu Simona , Baculescu Nicoleta , Niculescu Dan , Radian Serban , Muresan Andrei , Braha Elena , Poiana Catalina

Background: Multiple endocrine neoplasms (MEN) are a rare hereditary syndrome, caused by an autosomal dominant mutation due to germline mutation in the rearranged during transfection (RET) proto-oncogene. According to the new WHO guidelines, MEN type 2 (formerly known as MEN 2A) is characterised by medullary thyroid cancer (MTC), paragangliomas, primary hyperparathyroidism (PHP) and cutaneous lichen amyloidosis.Objectives: To present the clinical and par...

ea0093p4 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

Decrease in anticortisolic drug osilodrostat plasma exposure in patients treated with mitotane for an adrenocortical carcinoma

Thomeret Louis , Puszkiel Alicja , Balakirouchenane David , Bouys Lucas , Poirier Jonathan , Berthon Annabel , Ragazzon Bruno , Jouinot Anne , Guignat Laurence , Bessiene Laura , Libe Rossella , Bricaire Leopoldine , Groussin Lionel , Assie Guillaume , Blanchet Benoit , Bonnet-Serrano Fideline , Bertherat Jerome

Introduction: The steroidogenesis inhibitor osilodrostat (OSI), indicated for the medical treatment of endogenous Cushing’s syndrome, exhibits significant interindividual variability regarding the response to treatment (Pivonello et al. 2020). Plasma exposure may contribute to this variability. Our objective was to investigate the effect of concomitant use of mitotane (MIT), a potent inducer of CYP450 (3A4), on circulating OSI concentrations in patients treated f...

ea0093p5 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

An overview of adrenal vein sampling for primary aldosteronism in Croatia (2016–2023)

Lekić Ivan , Tomšić Karin Zibar , Alduk Ana Marija , Kaštelan Darko

Background: Although adrenal vein sampling (AVS) is a technically demanding procedure, it is still considered the gold standard for subtyping primary aldosteronism (PA). The aim of the study was to analyze the success rate of AVS in patients with PA.Methods: In all patients AVS was performed sequentially during continuous stimulation with adrenocorticotrophic hormone by one interventional radiologist. Adrenal vein cannulation was considered successful if...

ea0093p6 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

New possible pathogenic variants involved in pheochromocytomas and paragangliomas

Burciulescu Sofia Maria Lider , Gheorghiu Monica Livia , Patocs Attila , Braha Elena Emanuela , Badiu Corin

New possible pathogenic variants involved in pheochromocytomas and paragangliomasIntroduction: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the chromaffin tissues that store and release catecholamines in excess. Most pheochromocytomas are sporadic, usually resulting in unilateral adrenal tumor, but 25–45% harbour a germline mutation.Aim: To describe new possible pathogenic variants (VUS) involved in PPGLs.</...

ea0093p7 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

Identification and characterization of biologically active small molecules against primary aldosteronism driver mutations

Mir-Bashiri Sanas , Reincke Martin , Williams Tracy

Primary aldosteronism (PA) is a form of endocrine hypertension characterized by autonomous aldosterone secretion. Aldosterone-producing adenomas (APAs) are a significant cause of unilateral PA, where aldosterone overproduction is driven by a somatic mutation in an ion pump or channel. Multiple studies have shown that mutations in the KCNJ5 gene are the most prevalent in PA patients suffering from the unilateral subtype, and unilateral laparoscopic total adrenalectomy ...

ea0093p8 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

Remission rate of primary aldosteronism after unilateral adrenalectomy

Đukić Mirjana , Tomšić Karin Zibar , Knežević Nikola , Kaštelan Darko

Background: The existing consensus for patients with primary aldosteronism (PA) after unilateral adrenalectomy recommends annual follow-up to rule out persistence or recurrence of the disease.Objectives: The aim of the study was to assess the remission rate in patients with PA ≥1 year after adrenalectomy.Methods: Of the 41 patients who underwent adrenalectomy for PA between 2016 and 2021, 24 had available follow-up data and w...

ea0093p9 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

A rare case of bilateral micronodular adrenal cortical disease

Ozer Ozge , Yorulmaz Goknur , Kebapci Medine Nur

Background: Bilateral micronodular adrenal cortical disease (miBACD) is a rare and difficult-to-manage disease. miBACD is one of the causes of Cushing’s syndrome. miBACD is divided into primary pigmented nodular adrenocortical disease (PPNAD) and isolated micronodular adrenocortical disease. Its more common presentation is familial PPNAD, as part of Carney syndrome. We also presented a rare case of miBACD.Case presentation: A 20-year-old female pati...

ea0093p10 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

The fibroblast growth factor-23/Klotho axis in patients with acromegaly

Halupczok-Żyła Jowita , Jawiarczyk-Przybyłowska Aleksandra , Zembska Agnieszka , Słoka Natalia , Bolanowski Marek

Background: Acromegaly is a rare disease, mostly caused by a GH (growth hormone)-secreting pituitary adenoma. The pathomechanism of bone complications remains not fully explored. The fibroblast growth factor-23 (FGF-23)/Klotho axis regulates phosphate and vitamin D metabolism.Objectives: The study aimed primarily at evaluating FGF-23 and Klotho concentrations with regard to acromegaly activity. The secondary goal was to identify associations between FGF-...