Endocrine Abstracts

While axiomatic, it is worth reflecting carefully when planning research. The first step requires careful review of the sequence of processes linking the current state of the art of the evidence, to the hypothesis, then to the question/s testing the hypothesis and on to the nature of evidence required to answer those questions., This is of course required well before any consideration of the “how” those questions can be answered. One of the confounders in this carefu...

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Investigating the protein structural context of human genetic variants offers a powerful framework for understanding their effects. Recent years have witnessed an exponential growth in our ability to access structural information about the human proteome, driven by advancements in cryo-electron microscopy and computational protein structure prediction, exemplified by AlphaFold. In this talk, I will first briefly cover approaches obtaining a 3D structural model of your protein ...