Endocrine Abstracts

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The discovery of GnRH involved extraordinary insight, determination and creativity as well as conflict and competition where the players inadvertently advanced each other’s endeavours. However, many of us experienced great collegiality, collaboration and sharing reagents in these halcyon years. Many colourful and ambitious characters were involved in the recognition that a portal system transferred a factor from the brain to the pituitary supported by elegant experiments ...

An increased understanding of the DNA sequences and transcription factors (TFs) involved in regulating expression of the insulin gene, and the role that these TFs play in the developing pancreas has opened up new prospects for cell and gene therapy for diabetes. Gene therapy involves injection of an insulin gene construct into muscle, chosen as the most accessible tissue. The major challenges are efficiency of uptake and expression of the exogenous gene, processing of proinsul...