Endocrine Abstracts

Background: Diminished sodium iodide symporter (NIS) activity at the plasma membrane (PM) is frequently associated with suboptimal radioiodide (RAI) uptake and poor prognosis in differentiated thyroid cancer (DTC). Endocytosis is a key determinant of symporter activity, with our recent study demonstrating specific interaction of NIS with Adaptor Protein 2 (AP2) – a central player in endocytosis. Here, our objective was to determine whether NIS endocytosis...

Introduction: Metastatic phaeochromocytomas (PCC) and paragangliomas (PGL), collectively known as metastatic PPGL (mPPGL), represent uncommon neuroendocrine tumours for which no standardized treatment guidelines exist. The emerging therapeutic modality employing 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) has exhibited favourable tolerability in the management of these patients.Methods: In this...

BackgroundAdrenocortical carcinoma (ACC) is a rare but devastating tumour of the adrenal gland and the molecular mechanisms of pathogenesis remain incompletely understood. To gain novel insights into the cellular landscape of ACC, we compared single nuclei RNA sequencing (snRNA-seq) datasets from ACC and normal adrenal glands (NAGs).Methods: We isolated single nuclei from 12 ACC snap-frozen samples, including 6 primary tumours, 3 local r...

Prostate Cancer (PC) affects 1-in-6 men in the UK, and obesity 1-in-3, with rates of both increasing. High-fat diet is linked with increased risk of PC death, and volume of peri-prostatic adipose tissue (PPAT) is associated with increased risk of lethal PC/reduced therapy response. Despite this, molecular mechanisms underpinning obesity-driven PC remain poorly-understood. This is important since weight-gain and central obesity are major side-effects of PC trea...

Introduction: Although breast cancer (BC) is considered a treatable disease, >30% of patients with hormone receptor positive tumours will suffer recurrence post endocrine therapy. One of the fundamental features of cancer cells is their ability to modulate cell metabolism to facilitate survival, stress response, and proliferation. Increasing evidence suggests that these mechanisms play key roles in the development of treatment resistance. Recent publicatio...

The progression of thyroid cancer is dependent on cell motility, a highly complex process that involves the co-ordination of multiple signalling pathways, cell adhesion, and actin dynamics. The proto-oncogene pituitary tumor-transforming gene (PTTG)-binding factor (PBF/PTTG1IP) potently stimulates thyroid cancer cell migration and invasion via PBF phosphorylation by Src kinase at residue Y174. Recent phosphoproteomic and RNA-Seq analyses revealed that upregulation of PBF in Nt...