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Society for Endocrinology BES 2023

Glasgow, UK
13 Nov 2023 - 15 Nov 2023

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SfE BES is the UK's leading endocrinology meeting. It will return to Glasgow in 2023.

Oral Communications

Reproductive Endocrinology

ea0094oc4.1 | Reproductive Endocrinology | SFEBES2023

Unsupervised steroid metabolome cluster analysis to dissect androgen excess and metabolic dysfunction in 488 women with polycystic ovary syndrome – results from the prospective DAISy-PCOS study

Melson Eka , Rocha Thais P. , Veen Roland J. , Abdi Lida , McDonnell Tara , Tandl Veronika , Hawley James M. , Wittemans Laura B. L. , Anthony Amarah V. , Gilligan Lorna C. , Shaheen Fozia , Kempegowda Punith , Gillett Caroline D.T. , Cussen Leanne , Missbrenner Cornelia , Lajeunesse-Trempe Fannie , Gleeson Helena , Rees Aled , Robinson Lynne , Jayasena Channa , Randeva Harpal S. , Dimitriadis Georgios K. , Gomes Larissa G. , J. Sitch Alice , Vradi Eleni , Obermayer-Pietsch Barbara , O'Reilly Michael W. , Taylor Angela E. , Biehl Michael , Arlt Wiebke

Introduction: Polycystic ovary syndrome (PCOS) affects 10% of women and is associated with a 2-3fold risk of type 2 diabetes (T2D), hypertension, fatty liver and cardiovascular disease. Androgen excess has been implicated as a major contributor to metabolic risk in PCOS. We aimed to identify PCOS sub-types with distinct androgen profiles and compare their cardiometabolic risk.Methods: We cross-sectionally studied 488 tre...

ea0094oc4.2 | Reproductive Endocrinology | SFEBES2023

Maternal chronodisruption during gestation affects clock functioning in fetal tissues in a sex-dependent manner via melatonin-independent pathways

Semenovykh Kateryna , Honzlova Petra , Semenovykh Dmytro , Dočkal Tereza , Sladek Martin , Houdek Pavel , Greiner Philipp , Sumova Alena

Disruption of circadian regulation could trigger and exacerbate obesity, type 2 diabetes mellitus, and cardiovascular disease. Experiments on rats proved that the deleterious effects of chronodisruption are extremely severe, especially during early developmental stages. Only part of them could be prevented by maternal melatonin administration, suggesting that other pathophysiological mechanisms may be involved. To investigate the role of other mechanisms that might contribute ...

ea0094oc4.3 | Reproductive Endocrinology | SFEBES2023

Self-administering post-cycle therapy is associated with biochemical gonadal recovery in men stopping anabolic-androgenic steroid use

Grant Bonnie , Campbell John , Pradeep Anjali , Burns Angela D. , Bassett Paul , Abbara Ali , Saket Priyadarshi , Minhas Sukhbinder , Dhillo Waljit S. , McVeigh James , Bhasin Shalender , Jayasena Channa N.

Background: Millions of men worldwide take anabolic-androgenic steroids (AAS) to boost muscle growth, but risk psychosis, cardiomyopathy, stroke and death. Users avoid stopping AAS because they are fearful of low testosterone symptoms including sexual dysfunction, depression and suicidality. To avoid these symptoms, men often illicitly self-medicate a 2–12-week course of drugs including selective oestrogen receptor modulators to boost testicular function ...

ea0094oc4.4 | Reproductive Endocrinology | SFEBES2023

Intranasal kisspeptin: a novel, effective and non-invasive approach to stimulate reproductive hormones in patients with reproductive disorders

G Mills Edouard. , Delli Virginia , Chachlaki Konstantina , Silva Mauro SB. , Decoster Laurine , Ternier Gaetan , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie A. , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Swedrowska Magda , Forbes Ben , Giacobini Paolo , Prevot Vincent , Comninos Alexander N. , Dhillo Waljit S.

Background: Kisspeptin is a potent regulator of GnRH neurons with potential to treat reproductive and psychosexual disorders. However, administration is limited to the subcutaneous or intravenous routes. These invasive routes limit clinical development. Herein, we comprehensively examine the translational potential of intranasal kisspeptin administration for the first-time using rodent, human and pharmaceutical studies.Methods:</...

ea0094oc4.5 | Reproductive Endocrinology | SFEBES2023

Luteinising hormone receptor signalling is reliant on formation of distinct multi-receptor complexes

Walker Abigail , Hopkins Thomas , Howell Lesley , Farooq Zara , McCormick Peter , Jonas Kim , Hanyaloglu Aylin

Luteinising hormone (LH) and the luteinising hormone receptor (LHR) have key roles in steroidogenesis and ovulation, thus are central targets for fertility treatment. The LHR is a G protein-coupled receptor that predominantly signals through Gαs, although under conditions of high ligand concentration and/or high receptor density, as occurs during the mid-cycle LH surge, can also signal via Gαq/11. Yet, how LHR delineates signal pathway activation to coordinate pleiot...

ea0094oc4.6 | Reproductive Endocrinology | SFEBES2023

Tool development: Characterization of novel follicle-stimulating hormone receptor (FSHR) Inhibitors

Xu Ruijuan , Sureshkumar Sumetha , Agwuegbo Uche , Tran Hanh , Hopkins Thomas , Bousfield George , Jonas Kim

Follicle stimulating hormone (FSH) is a heterodimeric glycoprotein hormone, crucial for regulating female reproduction. Its actions are mediated through FSHR, a Class A G protein-coupled receptor (GPCR), which primarily couples to Gs/cAMP/PKA pathway to modulate ovarian follicle growth, granulosa cell proliferation, and estrogen production. In addition to dogmatic functions of FSH in reproduction, there is increasing evidence that FSH can act on extragonadal tissues. Specifica...