Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2023

Glasgow, UK
13 Nov 2023 - 15 Nov 2023

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SfE BES is the UK's leading endocrinology meeting. It will return to Glasgow in 2023.

ea0094oc7.1 | Thyroid | SFEBES2023

A copper-based metabolite of disulfiram upregulates sodium iodide symporter (NIS) gene expression to enhance thyroidal uptake of radionuclides in vivo

Brookes Katie , Zha Ling , Small Benjamin , Kim Jana , Manivannan Selvambigai , Thornton Caitlin , Kannappan Vinodh , Wang Weiguang , Nieto Hannah , Sunassee Kavitha , Blower Philip , Smith Vicki , Read Martin , McCabe Christopher

Introduction: New approaches to improve radioiodide (RAI) uptake are urgently required in RAI-refractory thyroid cancer. We previously identified disulfiram as a leading candidate to induce sodium iodide symporter (NIS) activity and promote RAI uptake. In vivo, DSF is metabolised to diethyldithiocarbamate (DDC) which binds metal ions. Here, we aimed to gain a mechanistic understanding of how DSF and it’s related metabolite Cu(DDC)2 imp...

ea0094oc7.2 | Thyroid | SFEBES2023

Examining latest costs and prescribing on Liothyronine (T3) by dose levels with respect to the 2017 Competition and Market Authority (CMA) investigation into liothyronine prices and the implementation of 2023 British Thyroid Association (BTA) guidance for appropriate patients suggesting Liothyronine daily dose levels of 5-10mg at possible split dose twice day

Stedman Michael , Taylor Peter , Premawardhana Lakdasa , Okosieme Onyebuchi , Dayan Colin , Heald Adrian

Background: CMA showed price paid for liothyronine tablets rose from £15.15 in 2009 to £258.19 in 2017; a £100 million fine against suppliers was made public December 2021. BTA published guidance on use of liothyronine for appropriate patients in May 2023 suggesting daily dose 5-10mg at possible split twice day. This report investigated link between amounts and costs of T3 prescribing for different dose levels over the last 6 years.<p class=...

ea0094oc7.3 | Thyroid | SFEBES2023

Influence of tyrosine availability on TSH-dependent cell proliferation and gene transcription in rat FRTL-5 thyroid cells

Crossley Victoria , Simbi Bigboy , Chang Ruby , Elliott Jonathan , Fowkes Robert , Syme Harriet

Tyrosine availability critically influences thyroid hormone synthesis, and thyroid disorders, such as hyperthyroidism, affect 1% of humans. In contrast, nearly 10% of mature/senior cats develop hyperthyroidism, but colourpoint breeds with mutations in the tyrosinase gene (e.g. Siamese) show reduced risk of developing hyperthyroidism, potentially due to increased availability of tyrosine (related to coat colouration). To establish how tyrosine availability can alter thyroid fun...

ea0094oc7.4 | Thyroid | SFEBES2023

The effectiveness of radioactive iodine vs thyroidectomy for paediatric grave’s disease: a systematic review and meta-analysis

He Shiyao George , Chia Li Ling Jolene , Pinto Diluka , Samuel Miny , Ho Cindy W.L. , Parameswaran Rajeev

Introduction: Definitive treatment for pediatric Grave’s disease includes radioiodine ablation (RAI) or thyroidectomy. The aim of this systematic review and meta-analysis was to compare the cure and relapse rates of RAI vs surgery as definitive therapy in children with Grave’s disease.Methods: A comprehensive search on Cochrane library, EMBASE, PUBMED and for English articles published on def...

ea0094oc7.5 | Thyroid | SFEBES2023

Thyroid cancer referral pathways: findings from an inner-city tertiary thyroid centre

Singh Ainesh , Agha-Jaffar Rochan , Cox Jeremy , Madani Gitta , Bhatia Kunwar , Moonim Mufaddal , Wernig Florian , Di Marco Aimee , Palazzo Fausto , Robinson Stephen , Tolley Neil

Background: Absence of effective clinical indicators for thyroid cancer, which has an excellent prognosis, means community ultrasounds (US) can be important in identifying risk. Where cytology is definitive it should be reviewed by appropriate MDT specialists. This study aimed to examine the outcomes from two-week-wait (2WW) referrals.Methods: To achieve these aims, we retrospectively reviewed 293 patients referred on th...

ea0094oc7.6 | Thyroid | SFEBES2023

Shallow whole genome sequencing (swgs) as an aiding tool in monitoring of thyroid cancer

Jumaah Ali Al , Levy Miles , Reddy Narendra , Allsopp Rebecca , Page Karen , Shaw Jacqui , Gohil Shailesh

Introduction: Liquid biopsies have revolutionised cancer care, from accurate diagnosis to guiding treatment and surveillance. Here, we used shallow Whole Genome Sequencing (sWGS); a cost-effective and easy-to-perform test to explore concordance of copy number alterations (CNAs) between formalin-fixed paraffin-embedded (FFPE) tissue extracted DNA and circulating cell-free DNA (cfDNA) in patients with Thyroid Cancer (TC) during different stages of the disease. <...