Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2023

Glasgow, UK
13 Nov 2023 - 15 Nov 2023

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SfE BES is the UK's leading endocrinology meeting. It will return to Glasgow in 2023.

Oral Poster Presentations

Bone and Calcium

ea0094op6.1 | Bone and Calcium | SFEBES2023

Sclerostin but not Dickkopf-related protein 1 predicts bone mass and markers of bone turnover in older adults

Christodoulou Marilena , Aspray Terence , Piec Isabelle , Frasser William , Schoenmakers Inez

Sclerostin (SOST) and Dickkopf-related protein 1 (DKK1) are antagonists of Wnt signalling, inhibiting osteoblast activity and indirectly stimulating osteoclast activity. SOST and DKK1 antibody therapy leads to increases in bone mass and bone formation. However, reported associations between plasma SOST and DKK1 concentrations and measures of bone mass and turnover are conflicting. This study in healthy older men and women (n =379; median 74.1 [IQR 71.5-77.0]y) investi...

ea0094op6.2 | Bone and Calcium | SFEBES2023

Measuring FGF23 in patients treated with burosumab

Piec Isabelle , Chipchase Allison , Miler Emma , Ramachandran Hari , Webb Emma , Fraser William D

Burosumab has become available as a treatment for children with X-linked hypophosphatemia (XLH) and is a recombinant fully human IgG1 against FGF23. By binding to the active FGF23, burosumab inhibits its effect and symptoms (growth retardation, rickets, enthesiopathy, low phosphate) may improve, however, not in all children. Concomitantly paediatricians are keen to measure FGF23, in treated children, to avoid overtreatment with burosumab, associated with potential calcificatio...

ea0094op6.3 | Bone and Calcium | SFEBES2023

A case of hypophosphatasia presenting during pregnancy

Livingstone Rachel

A 28 year old female was referred to endocrinology after routine bloods during first trimester of pregnancy demonstrated a low alkaline phosphatase (ALP) of 14U/l (range 30-130U/l). Calcium, phosphate and vitamin D were normal. There is no past medical history, no fragility fractures, no dental concerns and height was normal (157.5cm). Her only family history was her mother lost her teeth prematurely. Biochemical testing showed a raised copper level of 26.0µmol/l (range 1...

ea0094op6.4 | Bone and Calcium | SFEBES2023

HDR syndrome (hypoparathyroidism, deafness and renal dysplasia) Unveiled: A rare cause of profound hypocalcaemia and seizure

Shekar Nitin C. , Kamaruddin Shafie , Chu Guistina , Khan Irfan , Awadelkareem Abuzar

Background: HDR syndrome also known by the eponym Barakat syndrome, is a rare, autosomal dominant disorder characterized by the triad of hypoparathyroidism, sensorineural hearing loss, and renal abnormalities. It is caused due to mutation (haploinsufficiency) in GATA3 gene on chromosome 10p with a wide spectrum of phenotypic variations.Case Presentation: A 33-year-old lady presented to emergency department with an episod...