Bone and Calcium

ea0094p31 | Bone and Calcium | SFEBES2023

A single infusion of Zoledronic acid suppressed bone turnover markers for up to seven years: Results from the Zoledronate in the Prevention of Paget’s disease (ZiPP) study

Tang Jonathan , Fraser William , Phillips Jonathan , Piec Isabelle , Dunn Rachel , Keerie Catriona , Lewis Steff , Ralston Stuart , Investigators ZiPP

Zoledronate in the Prevention of Pagets disease (ZiPP) trial (ClinicalTrials.gov ID:NCT03859895) is a multi-centre, double-blind, placebo-controlled, randomised trial of Zoledronic acid (ZA) in sequestosome1 (SQSTM1) mutation carriers. SQSTM1 mutation has high penetrance and is associated with the early onset of Pagets disease of bone. Participants with the SQSTM1 genotype received either a single dose of IV 5mg ZA (Aclasta, Novartis); intervention group n...

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ea0094p32 | Bone and Calcium | SFEBES2023

Review of current guidelines on fracture risk recommendations in patients on hormonal therapies for Breast Cancer

Busch Sophia , Higham Claire

Introduction: Women prescribed hormonal therapies for breast cancer (eg Aromatase Inhibitors (AI) and ovarian suppression therapy (OST)) are at increased risk of fracture and monitoring of Bone Mineral Density (BMD) is needed. Recommendations for BMD monitoring and treatment interval thresholds differ between guidelines which has implications for management. We compared the outcomes from the application of 3 commonly used guidelines for bone health in women wi...

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ea0094p33 | Bone and Calcium | SFEBES2023

Service evaluation of the metabolic bone centre primary hyperparathyroidism registry

Neelam-Naganathan Dharshan , Komber Ahmad , Eastell Richard , Schini Marian

Background: At the Metabolic Bone Centre in Sheffield, UK, patients with asymptomatic primary hyperparathyroidism (PHPT) are followed up annually through a register, with annual blood tests, questionnaires inquiring about symptoms or renal stones within the past year, and biennial DXA scans, which doctors then evaluate. Patients are recalled to the clinic if their reported symptoms and/or biochemical results suggest abnormalities associated with PHPT requiring...

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ea0094p34 | Bone and Calcium | SFEBES2023

Abstract withdrawn...

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ea0094p35 | Bone and Calcium | SFEBES2023

Bones, physician’s moans, and causes unknown: a challenging case of multifactorial hypocalcaemia

Phillips Ben , Michaelidou Maria , Obeid Mariam , Dunstan Rosalyn , Laing Ian , Young Elaine , Howell Simon , Kaushal Kalpana

Sclerotic bone lesions are a rare cause of hypocalcaemia. Calcium and vitamin D malabsorption are recognised complications of gastric bypass surgery. We describe the case of a 45 year-old woman with severe persistent symptomatic hypocalcaemia secondary to metastatic breast cancer, complicated by a previous Roux-en-Y gastric bypass, and the development of hypoparathyroidism. Her corrected calcium levels fell repeatedly and precipitously despite treatment with up to 8g/day oral ...

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ea0094p36 | Bone and Calcium | SFEBES2023

Unraveling the enigma: Calcifications and complications in PHP

Aslam Aisha , ManoharRao Balmuri Laxmi

Introduction: Pseudo-hypoparathyroidism (PHP) is a rare endocrine disorder characterized by resistance to parathyroid hormone (PTH). We present a case of a 33-year-old, focusing on the clinical presentation, diagnostic, and management strategies, with particular attention to skeletal manifestations and tissue calcifications.Case Description: The patient presented to the hospital with severe symptomatic hypocalcaemia. Ini...

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ea0094p37 | Bone and Calcium | SFEBES2023

Cinacalcet in primary hyperparathyroidism: The birmingham experience

Shafiq Nauman , Malik Ahmed , Gittoes Neil , Criseno Sherwin , Hassan-Smith Zaki

Background: In the UK, 1 to 4 per 1000 people have primary hyperparathyroidism (PHPT) and are at risk of hypercalcaemia and its complications. Whilst surgery is the only curative option in the management of PHPT, several patients are managed conservatively or medically. Cinacalcet (a calcimimetic) has a role in PHPT management, in those who have declined or are unable to progress to surgery. It is important that the use of Cinacalcet in these cases adheres to ...

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ea0094p38 | Bone and Calcium | SFEBES2023

Familial hypocalciuric hypercalcaemia - benign diagnosis not to be missed!

Linn Su Khin Kyaw , Hazlehurst Johnathan , Juszczak Agata

Background: Familial hypocalciuric hypercalcaemia (FHH) is a rare benign autosomal dominant condition which causes life-long mild to moderate hypercalcaemia. It is usually underdiagnosed due to lack of symptoms in majority of patients and low rate of screening even among endocrinologists. Recent NHS England National Genomic Directory testing criteria for FHH recommend testing patients presenting with hypercalcaemia and calcium creatinine clearance ratio (CCCR)...

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ea0094p39 | Bone and Calcium | SFEBES2023

PTH Independent hypercalcaemia in a pregnant patient

Athar Iqbal Khan Muhammad , Ahmed Baig Fraz , Elhag Ali Hisham

We report an interesting case of a rare presentation of hypercalcemia in a 27-year-old pregnant woman with history of Uterine fibroids. The patient arrived at the emergency department with two weeks history of worsening lower abdominal pain. She had resorted to sleeping in a sitting position due to the intensity of pain. There was no vaginal bleeding and bowels were not opened for four days. Physical examination revealed dehydration, tenderness in the lower abdomen with an abd...

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ea0094p40 | Bone and Calcium | SFEBES2023

Importance of Evidence-based management of Primary Hyperparathyroidism

Ahmed Nabeel , Hatton Rebecca , Harris Laura , Tabasum Maria , Clarke-Burns Rossana , Brotherton Sophie , Srinivasshankar Upendram

Background: Primary Hyperparathyroidism (PHPT) is the leading cause of hypercalcaemia. Early diagnosis and management is important to prevent long term complications. National institute of clinical excellence (NICE) published guidelines on diagnosis and management of Primary Hyperparathyroidism and we sought to compare our practice with the NICE guideline (NG 132).Methods: This was a retrospective observational study of ...

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ea0094p41 | Bone and Calcium | SFEBES2023

Tumour-to-tumour metastasis to the parathyroid causing dual pathology hypercalcaemia

Sankar Adhithya , Brindle Rachel , Tymms James , O'Connell Ian , Kumar Mohit

An 85-year-old woman attended the endocrine clinic with hypercalcaemia and raised PTH levels. Her background included breast cancer treated with bilateral mastectomy and hormone therapy 3 years previously, with no evidence of disease on imaging 2 years previously. On attendance, her clinical examination was unremarkable, with no palpable neck mass. Biochemical investigations showed: Adj Ca 3.12 mmol/l, PTH 45.0 pmol/l, PO4 0.94 mmol/l, ALP 119U/l, Alb 45g/l, 25-OH Vit D 15.7 n...

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ea0094p42 | Bone and Calcium | SFEBES2023

Neonatal hypocalcaemia and association with maternal magnesium sulphate (MgSO4) administration in a single center, at the neonatal unit in walsall manor hospital

Kollurage Udeni , Morley Elizabeth , Baachaa Zuro , Dogar Azeem , Gireesh Rayasandra

Introduction: Hypocalcaemia is a biochemical abnormality noted in neonates and considered a possible side-effect of maternal MgSO4 administration. Suggested mechanism is maternal hypermagnesemia inhibits secretion of maternal parathyroid hormone, causing maternal and foetal/neonatal hypocalcaemia.Objectives: This study is aimed to identify common risk factors, presentation, biochemical abnormalities, severity, and any co...

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ea0094p43 | Bone and Calcium | SFEBES2023

Paradoxical severe hypercalcemia in a male bodybuilder with rhabdomyolysis: A case report

Islam Quazi , Armeni Eleni , Eltayeb Randa , Grossman Ashley , Khoo Bernard , Mladenova Irina , Patel Dipesh , Sahoo Saroj , Shekhda Kalyan , Yousseif Ahmed , Karra Efthimia

Paradoxical severe hypercalcemia is a rare phenomenon observed in some patients in delayed phase following rhabdomyolysis. We present a case of 33-year-old male who developed severe hypercalcemia following successful treatment of rhabdomyolysis. Patient was admitted with agitation and disinhibition, was intubated in A&E due to metabolic acidosis (pH 6.7), hyperkalemia (K+ 7.3 mmol/l), lactic acidosis (23 mmol/l), and pyrexia (40°C). Toxicology screening shown presence...

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ea0094p44 | Bone and Calcium | SFEBES2023

Viral hypercalcemia

Latif Wajeeha , Mansoor Raza Mohammed , Ali Asif

A 64-year-old woman presented acutely with dry cough, difficulty in eating, diarrhoea and weight loss. Her past medical history included cervical carcinoma in situ treated with laser therapy. She was found to be hypercalcaemic, with a corrected calcium of 2.84 mmol/l. During admission, the calcium ranged between 2.8-3.87 mmol/l. The PTH ranged between 0.2-0.4 pmol/l (1.3-9.3 pmol/l). She had raised inflammatory markers and deranged liver function tests. On review, she...

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ea0094p185 | Bone and Calcium | SFEBES2023

A retrospective audit of patients with fragility hip or vertebral fracture - assessing suitability for romosozumab

Batten Lucy , Melrose Rachel , Narayanan Deepa , Aye Mo

Introduction: The current UK guidelines (NICE TA791) recommend the use of romosozumab, a monoclonal sclerostin inhibitor, for patients at high imminent risk of fragility fractures. However, elderly patients with a very high risk of fractures often exhibit frailty and other comorbidities. This retrospective survey was conducted in a major trauma centre in northern England to evaluate the potential utilisation of romosozumab in a real-world setting.<p class=...

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ea0094p186 | Bone and Calcium | SFEBES2023

Teriparatide efficacy in the real world: a single UK centre experience

Shah Preet , Crossland Helen , Abbas Afroze , Seejore Khyatisha

Introduction: Teriparatide is an osteoanabolic agent approved for the treatment of osteoporosis in postmenopausal women, in men with increased fracture risk, and in glucocorticoid-induced osteoporosis. The aim of this study was to evaluate the real-world use and efficacy of teriparatide.Patients and Methods: We retrospectively assessed all patients with available data, who received teriparatide at Leeds Teaching Hospital...

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ea0094p187 | Bone and Calcium | SFEBES2023

Hyperparathyroidism in the young: A case and investigation pathway

Aye Thant Aye , Lewis Alexander

Introduction: Primary hyperparathyroidism may be sporadic or occur as part of a genetic predisposition. Inactivation of CDC73 tumour suppressor gene can cause hyperparathyroidism-jaw tumour (HPT-IJ) syndrome, parathyroid carcinoma or familial isolated hyperparathyroidism (FIHP).Case details: We report a 26 year old gentleman, previously fit and well who was found to have hypercalcemia on a routine testing. Renal ultrasou...

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ea0094p188 | Bone and Calcium | SFEBES2023

A clinical audit on pre-operative work up and post-operative follow up in patients undergoing surgical management for primary hyperparathyroidism in a large tertiary Centre in the United Kingdom

Wijewickrama Piyumi , Simpson Helen , Baldeweg Stephanie , Srirangalingam Umasuthan , Abdel-Aziz Tarek , Kurzawinski Tom , Chung Teng-Teng

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Aim of this audit was to assess clinical, biochemical parameters, localisation modalities and outcome in patients undergoing parathyroidectomy at University College London Hospital (UCLH).Methods: We audited all patients aged 15-years or above, undergoing parathyroidectomy, from 01-02-2018 to 31-12-2021 at UCLH via retrospective data collectio...

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ea0094p189 | Bone and Calcium | SFEBES2023

Resistant hypocalcaemia in a patient with prostatic adenocarcinoma with extensive osteoblastic metastasis

Sahoo Saroj , Armeni Eleni , Bouloux Pierre , Grossman Ashley , Islam Quazi , Karra Eftimia , Khoo Bernard , Naeem Ammara , Nwokolo Muna , Patel Dipesh , Shekhda Kalyan , Silverwood Clare , Yousseif Ahmed

Introduction: Hypocalcaemia is rare in patients with malignancy, occurring in <2% of patients with malignancy. Osteoblastic bone metastases as an aetiology of hypocalcaemia are further rare.Case description: A 75-year-old male presented to emergency with back pain, and immobility. He was diagnosed to have prostate cancer in 2019. A bone scan in April 2022 showed extensive sclerotic metastases involving axial and prox...

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ea0094p190 | Bone and Calcium | SFEBES2023

Parenteral bisphosphonate therapy is effective and safe when given prior to parathyroid surgery in severe primary hyperparathyroidism

Maarouf Amro , Winfield Jessica , Hazlehurst Jonathan , Joseph Sonia , Shepherd Lisa , Rahim Asad , Juszczak Agata

Background: Primary hyperparathyroidism may severely manifest with an adjusted calcium >3.5mmol/l and increased risk of prolonged postoperative hypocalcaemia. Formal consensus on preoperative optimisation appears lacking, especially around the utility of parenteral bisphosphonate treatment. Bisphosphonate therapy has been demonstrated to cause prolonged hypocalcaemia when given to patients with a history of parathyroidectomy....

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ea0094p191 | Bone and Calcium | SFEBES2023

Spontaneous remission of hypercalcaemia in PHPT due to necrosis of parathyroid adenoma

Wahid Alam , Turner Jeremy , Pain Simon

Primary hyperparathyroidism (PHPT) affects approximately 0.3% of the UK population. The most frequent cause is solitary parathyroid adenoma, less commonly parathyroid hyperplasia, multiple adenomas, and parathyroid carcinoma. Cinacalcet is a calcimimetic which may be used in treatment of PHPT in certain circumstances. We report here a case of PHPT, treated by Cinacalcet, wherein apparently spontaneous necrosis of a parathyroid adenoma and resolution of hypercalcaemia occurred....

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ea0094p192 | Bone and Calcium | SFEBES2023

Aetiological complexity of Hypercalcaemia – A case report

Qamar Imran , Khan Haris

Background: Hypercalcaemia in endocrine patients often poses diagnostic challenge, with hyperparathyroidism and familial hypocalciuric-hypercalcaemia(FHH) being common differentials. This case-report presents unique and complex aetiology, underscoring need for comprehensive evaluation.Case-Description: We present case of 57-year-old Caucasian-woman referred to our clinic with persistently elevated calcium and parathyroid...

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ea0094p193 | Bone and Calcium | SFEBES2023

Genetic Testing in Endocrinology: a clinical audit assessing the appropriate use, documentation, and communication of results

Madhotra Ruchika , Mundell Natasha , Hazlehurst Jonathan

Background: Confirming a genetic diagnosis earlier in patient pathways has multiple benefits: it informs and directs clinical management, enables patients to access support organisations, and helps patients adjust to their lifelong condition. This audit assessed the appropriate usage of genetic testing within Endocrinology at Birmingham Heartlands Hospital (BHH). The key three outcomes investigated were whether genetic testing was being appropriately ordered; ...

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ea0094p194 | Bone and Calcium | SFEBES2023

Management of primary hyperparathyroidism- A retrospective audit on use of cinacalcet vs surgical intervention

Chikthimmah Vineeth , Lim Jonathan , Skurok Philip

Objective: To evaluate the efficacy of medical management of hyperparathyroidism and evaluate the financial and healthcare impact of delay in surgical intervention within a district general hospital. To assess the duration of use of cinacalcet prescriptions, compare wait times for surgery and assess the service needs.Method: We retrospectively evaluated all patients with primary hyperparathyroidism who received cinacalce...

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ea0094p195 | Bone and Calcium | SFEBES2023

A case of Severe hypercalcemia secondary to Milk-Alkali syndrome:

Nagarajah Kalyani , Panagiotou Grigorios , George Lindsay , Evans Marc

Milk alkali syndrome is a rare and distinctive disorder caused by ingestion of large amounts of calcium and absorbable alkali resulting in hypercalcemia. It is characterized by a triad of hypercalcemia, metabolic alkalosis and renal failure. Here we present a 59 years old female patient, who presented to Emergency department for a fall and Syncopal episode. She had a few days history of increasing thirst, polyuria and diffuse abdominal discomfort. This prior to her sync...

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ea0094p196 | Bone and Calcium | SFEBES2023

An unexplained case of phosphaturic hypophosphataemia

Basavaraju Navya , Abdulkareem Mustafa , Eardley Kevin , Moulik Probal

Introduction: We present an unusual case of hypophosphataemia with diagnostic dilemma.Case: 43-year-old female presented with 4-year history of muscle weakness, fatigue, bony pains, and limb paraesthesia. There was no background of fractures or iron deficiency. Her medications included amitriptyline and probiotics. She was a non-smoker and teetotaller; mother was short stature, father normal height. There was no family h...

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ea0094p197 | Bone and Calcium | SFEBES2023

Hypokalemia associated with Meropenem administration: a case report

Al-Qaysi Amina , Timamy Abdulmalik , Fernandes Alysid , Chizooma Eugine , H Ahmed Mohamed , Owles Henry , Panourgia Maria

Introduction: Hypokalemia is one of the commonly encountered electrolyte derangements in clinical practice. Numerous conditions and certain medications can trigger hypokalemia such as Piperacillin/Tazobactam, Flucloxacillin, Cephalexin and Vancomycin.Case report: A 72-year-old lady was admitted following a fall sustaining a right neck of femur fracture. Prior to this admission, she was on chemotherapy for non-small cell ...

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ea0094p322 | Bone and Calcium | SFEBES2023

Osteoporosis in a young male patient

Tsoutsouki Jovanna , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 58 year-old man presented with backache and was found to have T10-T12 vertebral fractures on spinal-MRI. He was diagnosed with osteoporosis on a DEXA-scan (lumbar-spine T-score-2.6) and was treated with Alendronate and Cholecalciferol at a neighboring hospital. He was referred to the endocrine bone-clinic for a second opinion regarding his osteoporosis. He had a history of multiple small bone fractures and Brucellosis that required a 2-month bed-rest. His family history incl...

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ea0094p323 | Bone and Calcium | SFEBES2023

Analysis of the variables related to osteoporosis in chronic kidney disease patients from a latin american cohort

Dulcey Luis , Theran Juan , Ciliberti Maria , Blanco Edgar , Gomez Jaime

Introduction: Chronic kidney disease is a pathology that has a great global impact on public health and its association with osteoporosis in this group of patients, however there are few regional descriptions.Methods: retrospective, descriptive and longitudinal study. Documentary data collection applying validated densitometric criteria as well as the epidemiological characteristics of the population. Tabulation and anal...

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ea0094p324 | Bone and Calcium | SFEBES2023

Age-specific reference intervals of Abbott intact parathyroid hormone (PTH) in adults

Kalaria Tejas , Lawson Alexander , Duffy Joanne , Agravatt Ashishkumar , Harris Steve , Ford Clare , Gama Rousseau , Webster Craig , Gittoes Neil

Background: Assays for parathyroid hormone (PTH) are not standardized and therefore method-specific reference intervals are necessary for interpretation of results. PTH increases with age in adults but age-specific reference intervals for the Abbott intact PTH (iPTH) assay are not available. It is challenging and resource intensive to derive age-specific reference intervals by direct method because, depending on number of age partitions, samples from a large n...

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ea0094p325 | Bone and Calcium | SFEBES2023

Case Report: Ectopic hyperparathyroidism with transient hyperthyroidism

Shafana Ahamed Sadiq Dr , Jamal Kareem Mr , Steve Hyer Dr

Ectopic parathyroid glands arise from aberrant migration during early stage of development. Lack of successful identification leads to failed parathyroid surgery and persistent hyperparathyroidism.Case History: A 57-year-old lady presented with abdominal discomfort and diffuse bone pain. Her corrected serum calcium was raised at 2.81mmol/l, reduced serum phosphate with an inappropriate intact PTH concentration of 10.5 pmol/l. Initial, vi...

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ea0094p326 | Bone and Calcium | SFEBES2023

Two cases of familial hypocalciuric hypercalcaemia (FHH) due to a homozygous CaSR gene mutation (c.-10C>T)

Livingstone Rachel , Talla Maria

Familial hypocalciuric hypercalcaemia (FHH) is a rare autosomal dominant condition due to a mutation in the calcium-sensing receptor gene (CaSR). The CaSR is located on chromosome 3 and mutations are commonly heterozygote mutations causing loss of function. Heterozygote mutations demonstrate benign disease with mild, asymptomatic hypercalcaemia. Homozygous mutations in the CaSR usually present with neonatal severe hyperparathyroidism (NSHPT) in the first few weeks of life and ...

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ea0094p327 | Bone and Calcium | SFEBES2023

Hypercalcaemia due to hypervitaminosis D

Muhammad Zubair Ullah Hafiz , Graveling Alex

Background: Vitamin D supplements are readily available without prescription. Although vitamin D toxicity is infrequent, rising use may lead to an increase in reported cases. We present a case of hypercalcemia and acute kidney injury due to excess vitamin D intakeCase: A 46-year-old woman was admitted with three-month history of lethargy, reduced oral intake, and constipation. She also experienced intermittent nausea and...

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ea0094p328 | Bone and Calcium | SFEBES2023

A rare case of Intrathyroidal parathyroid adenoma causing refractory hypercalcaemia. A challenging diagnostic and therapeutic journey

Rathi Kiran , Nadeem Sajjad

Introduction: Hypercalcemia is a common clinical abnormality seen in clinical practice. One of the leading causes of hypercalcemia is Primary hyperthyroidism from a parathyroid adenoma. While the ectopic parathyroid tissue is typically found in the thymus and anterior mediastinum, Intrathyroidal parathyroid adenoma is a challenging cause of primary hyperparathyroidism leading to persistent hypercalcemia even post-surgery.Case His...

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ea0094p329 | Bone and Calcium | SFEBES2023

Persistent Hypophosphatemia and recurrent seizures after Ferric Carboxymaltose (FCM)

Subbiah Kasi , Perumal Samundeeshwari

Intravenous iron formulations allow administration of high doses of elemental iron enabling correction of total iron deficit in one or two infusions. An underappreciated complication is hypophosphatemia from increased fibroblast growth factor 23 (FGF-23) secretion. An 85-year-old male presented with a second episode of generalized tonic-clonic seizures. The first episode was a month ago, and serum phosphate was 0.2 mmol/l (0.8-1.4). He was treated with phosphate replacement al...

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ea0094p330 | Bone and Calcium | SFEBES2023

Retrospective audit on biochemical, radiological investigations done prior to Parathyroidectomy for Primary Hyperparathyroidism

Kumar Sheethal , Abdulrahim Emad , Elena-Singh Andrada , Jones Bethany , Chauhan Rajveer , Natesh Basavaiah , Harrold Christopher , Howe David , Pratibha Machenahalli C

As per NICE guideline, referral for parathyroidectomy need to be according the below, symptoms of hypercalcaemia or End-organ disease (renal stones, fragility fractures or osteoporosis) or An albumin-adjusted serum calcium level of 2.85 mmol/litre or above.Methods: We conducted a retrospective analysis of investigations done as per recommendation of NICE guidelines for patients who underwent Parathyroidectomy under t...

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ea0094p331 | Bone and Calcium | SFEBES2023

An interesting case of a complex parathyroid adenoma, mimicking the biochemistry of Parathyroid Carcinoma

Zaki Beenish , Salema Valmiki

A 75-year-old lady was referred to our centre from a local DGH, where she presented with constipation, reduced consciousness and acute confusion. She was found to have severe hypercalcaemia (Adjusted Calcium 5.21mmol/l), with PTH of 1473ng/l, and urine calcium of 13.8mg/24 h. Based on available biochemistry, a presumptive diagnosis of Parathyroid Carcinoma was made, and Hypercalcemia management was started. She was given about 3 litres of fluid and 60mg of pamidronate. Subsequ...

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ea0094p332 | Bone and Calcium | SFEBES2023

A Rare presentation of a common Endocrine Disorder: Grave’s Thyrotoxicosis induced severe symptomatic Hypercalcemia

Sohail Sara , Foka Anna , Murphy Noel , Farah George

Introduction: Hypercalcemia has wide spectrum of diagnosis. Hyperthyroidism is known cause of parathyroid hormone independent cause of hypercalcemia. Increased osteoclast activity with excess bone resorption is underlying cause. Thyrotoxicosis associated hypercalcemia is usually asymptomatic, mild to moderate hypercalcemia is seen in 20% of patients, but severe hypercalcemia is rare. We report a case of young male who presented with abdominal pain, vomiting se...

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ea0094p333 | Bone and Calcium | SFEBES2023

An unusual case of refractory hypocalcaemia

Coco Mohamed , Sheikh Katrina , Shakher Jayadave , Osman Basheir

Authors: Mohamed Coco, Katrina Sheikh, Basheir Osman, Jayadave Shakher: Department of Acute Internal Medicine, Birmingham Heartlands Hospital-University Hospitals BirminghamIntroduction: Although skeletal metastatic diseases have commonly been associated with hypercalcemia; we present a case of severe hypercalcemia secondary to extensive skeletal sclerotic metastatic disease.Case: ...

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ea0094p334 | Bone and Calcium | SFEBES2023

Primary Hyperparathyroidism in Pregnancy

Arabi Noon , Jude Edward , Elkhenini Hanaa , Krishnamurthy Roopa , Gondane-Sweetman Purnima , Ellis Tracey

Introduction: Hypercalcaemia in pregnancy is an uncommon event that can cause major maternal morbidity and/or foetal morbidity and mortality. We present a case report and discuss management.Case: A 34-year-old woman was seen initially in endocrinology clinic with primary hyperparathyroidism. A neck ultrasound scan did not identify a parathyroid adenoma, but parathyroid MIBI scan suggested a left inferior parath...

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ea0094p335 | Bone and Calcium | SFEBES2023

Iatrogenic hypercalcaemia in a patient with duchenne muscular dystrophy: a case report highlighting multifactorial aetiology and therapeutic considerations

C. Shekar Nitin , Vanka Ramesh , Jajah Bilal , khan Irfan , Awadelkareem Abuzar , Thanda Hnin

Background: Duchenne muscular dystrophy (DMD) is a progressive muscle disorder characterised by muscle wasting and weakness. It is often associated with intracellular hypercalcaemia in dystrophin deficient muscle leading to disease progression. We present a comprehensive case report of extracellular hypercalcaemia in a DMD patient, a rare complication, emphasising the interplay of iatrogenic factors, immobilisation, and therapeutic approaches.<p class="abs...

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Society for Endocrinology BES 2023

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