Reproductive Endocrinology

Background: Male hypogonadism is a frequent reason for referrals to secondary care. Work up and approach to diagnosis and treatment varies among practicing physicians and proper work up and monitoring is crucial for safe and effective Testosterone replacement therapy (TRT). Methods: Retrospective case reviews for all men who were prescribed TRT via secondary care endocrine unit between September 2021 and September 2022.<...

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ea0094p108 | Reproductive Endocrinology | SFEBES2023

A comprehensive transethnic metabolomic analysis in women with PCOS in the born in bradford (BiB) study

Deshmukh Harshal , Sathyapalan Thozhukat

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder of women of reproductive age. Comprehensive metabolic profiling of women with PCOS across different ethnicities will help in understanding the pathophysiology of this condition.Methods: The Born in Bradford (BiB) study is a UK longitudinal birth cohort. Profiling of circulating lipids, fatty acids, and metabolites was do...

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ea0094p109 | Reproductive Endocrinology | SFEBES2023

Butyrate alleviates adipose mitochondrial dysfunction and inflammation in experimental model of polycystic ovarian syndrome by modulation of HIF-1α/MIF-dependent mechanism

Areloegbe Stephanie , Olaniyi Kehinde

Impaired adipose tissue remodeling has been suggested as a pathophysiological driver of endocrinometabolic events in PCOS models, a condition that affects 6-21% of reproductive-aged women worldwide. Mitochondrial dysfunction, especially in the adipocyte plays a key role in adipose tissue inflammation that possibly aggravates endocrine/metabolic phenotypes in PCOS. Studies have reported Short-chain-fatty acids (SCFAs) as metabolic modulators that potentiate energy homeostasis. ...

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ea0094p110 | Reproductive Endocrinology | SFEBES2023

Do all women with turner syndrome with 45, X/46, XY mosaic karyotype need early gonadectomy?: Experience from an adult tertiary care centre

A D Mathara Diddhenipothage Mathara Diddhenipothage Shani , J Beck Beck Katharina , Calanchini Matilde , Shears Deborah , E Turner Helen

Introduction: Reports suggest the karyotype of up to 10% of women with Turner syndrome (TS) includes presence of a Y chromosome. Current guidelines recommend early gonadectomy given the potential risk of gonadoblastoma. However, the evidence basis for this practice is not strong. We aimed to assess pubertal development, clinical features, incidence of gonadoblastoma and long-term outcome including pregnancy in an adult-tertiary care TS clinic.<p class="abs...

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ea0094p111 | Reproductive Endocrinology | SFEBES2023

Immunometric and functional measurement of endogenous vasoinhibin in human sera

Zamora Magdalena , Harris David , Davies Nils , Ebnet Johannes , Radermacher Peter , Brucker Cosima , Waller Christiane , Pablo Robles Juan , Bertsch Thomas , Clapp Carmen , Triebel Jakob

Circulating levels of the antiangiogenic protein vasoinhibin (16 kDa PRL), a fragment of prolactin, are of interest in vasoproliferative retinopathies, preeclampsia, and peripartum cardiomyopathy, but are unknown due to the lack of a quantitative assay. Here, human serum samples were investigated for the concentration and bioactivity of vasoinhibin using a novel enzyme-linked immunosorbent assay (ELISA) for human vasoinhibin employing an anti-vasoinhibin monoclonal antibody, a...

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ea0094p112 | Reproductive Endocrinology | SFEBES2023

Are we over scanning women with turner syndrome who have the lowest risk of aortic dissection?

Glatzel Hannah , Njue Faith , Turner Helen , Orchard Elizabeth

Women with Turner Syndrome (TS) are at significantly increased risk of aortic dilation and dissection. However, predicting the risk of aortic dissection (AoD) is difficult with many women attending annual appointments with time, travel and parking costs and resource implications. We developed a risk-based pathway based on the international guidelines, enabling closer follow up for those with a greater risk and reduce the frequency of appointments for those at the least risk.</...

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ea0094p113 | Reproductive Endocrinology | SFEBES2023

Cord blood prolactin in the assessment of neonatal oxygenation at partition

Hashim Ibrahim , Abraham Elizabeth

Introduction: Cord blood gases are measured following partition and are used as surrogate markers in the assessment of fetal oxygenation status at delivery and in identification of risk for neonatal encephalopathy. Low maternal prolactin levels were associated increased risk of respiratory distress syndrome. This study measured cord blood prolactin levels and correlated values with blood gases to examine possible value in assessment of fetal stress during deli...

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ea0094p114 | Reproductive Endocrinology | SFEBES2023

Assessment of antenatal anxiety and depression in pregnant women with polycystic ovarian syndrome (PCOS)

Floyd Ruairi , Hughes Nessa , O'Sullivan Lisa , Hevey David , Murphy Niamh , Hinds Catherine , Owens Lisa

Background: Women with PCOS experience higher rates of depression and anxiety. There is a paucity of research relating to perinatal mental health in women with PCOS, as well as a lack of evidence-based guidelines for assessment and management of mental disorders specific to pregnant women with PCOS. Limited available evidence suggests PCOS is associated with a higher prevalence of perinatal mental health disorders. However, perinatal guidelines currently do no...

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ea0094p115 | Reproductive Endocrinology | SFEBES2023

A case of neonatal hyperthroidism; associated with persistently elevated maternal thyroid rrceptor antibody (TRAb levels), post thyroidectomy for graves’ disease. Mother was clinically euthyroid on thyroxine replacement

Umair Shehzad Muhammad , Yee Sharlei , Abouglila Kamal , Altayeb Abdalaziz

30 yr/F, presented with C/O of palpitations, heat intolerance, significant unintentional weight loss with bulging of eyes and diplopia on extremes of vision. She had a background history of asthma, PCOS, obesity and difficulty in conceiving. OE, there was a smooth painless goiter. TFTs at diagnosis: TSH <0.05, T4=83, T3 >30.8 and TSH receptor antibody level (TRAB) of 9.0. She developed skin reaction to both Carbimazole and PTU, hence treated with total thyroidectomy wi...

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ea0094p116 | Reproductive Endocrinology | SFEBES2023

Patient and healthcare providers experience of access to menopause-related information and menopause-care provision across the UK: Results from a nationwide survey

Koysombat Kanyada , Pedder Hugo , Vinogradova Yana , Qayum Ambreen , N Comninos Alexander , Talaulikar Vikram , Panay Nick , S Dhillo Waljit , Mukherjee Annice , Abbara Ali

Menopause management guidelines advocate a personalised, evidence-based approach to menopause-care. This study explored the current landscape of menopause-care, from both patients and healthcare-providers perspectives, to better understand barriers to menopause-care across the UK.Methods: A 25-question online patient-survey and a 23-question GP-survey was designed with individuals with lived-experience of menopause to underst...

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ea0094p117 | Reproductive Endocrinology | SFEBES2023

Management of PCOS – patient and clinician perspectives on quality of clinical care in the United Kingdom

Bhattacharyya Shiuli , Talaulikar Vikram , H Al Wattar Bassel , Clarke Sophie

Background: Polycystic ovarian syndrome (PCOS) is the commonest endocrine condition affecting women of reproductive age, often adversely impacting their quality of life. Delayed diagnosis and poor patient experience are common themes reported by affected women. Several factors contribute to poor clinical care including the lack of specialised multi-disciplinary clinics and poor clinician familiarity with the varied health needs of affected women. We aimed to i...

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ea0094p118 | Reproductive Endocrinology | SFEBES2023

An audit of elevated serum testosterone in females with discrepant results

Miler Emma , Tam Trevor , Amjad Wajiha , Ahluwalia Rupa , Chipchase Allison

Background: While investigating hyperandrogenism in women, local laboratory policy dictates adult females with a serum testosterone of >3.5 nmol/l should be confirmed with an alternative method to exclude interference by cross-reacting substances. Patients who were on testosterone replacement or had a previous result in the same year were excluded. We explore the biochemical investigation of discrepant testosterone in females.<strong...

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ea0094p119 | Reproductive Endocrinology | SFEBES2023

Investigating the therapeutic potential of HDAC inhibition on renal disorder in letrozole-induced polycystic ovarian Wistar rats

Mohammed Al-Amin , Olaniyi Kehinde

Background: Polycystic ovarian syndrome (PCOS) is a multifactorial condition with metabolic-related complication, including chronic renal disorder, which is the leading cause of renal transplant globally. HDAC inhibitors (HDACi) have been suggested to protect renal function against biological assaults. Nonetheless, the current study investigated the restorative role of HDACi, butyrate in experimental PCOS-induced renal disorder.M...

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ea0094p120 | Reproductive Endocrinology | SFEBES2023

48,XYYY – a rare case in our endocrinology clinic

Al Jumaah Ali , Levy Miles , Gohil Shailesh , Barwell Julian , Bremner Emma , Barrowcliffe Mary , Reddy Narendra

Introduction: 48,XYYY is a rare condition where two extra Y chromosomes alter the neurological, skeletal and reproductive development of the affected individual. Clinical features are usually subtle and the diagnosis is not suspected until fertility issues arise. Here, were report an adult patient with 48,XYYY in the Endocrinology Clinic.Case report: A 24-year-old male was referred to UHL Endocrinology Clinic following i...

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ea0094p121 | Reproductive Endocrinology | SFEBES2023

Hypoglycaemia in pregnancy post-bariatric surgery: A case series

Narunsky Rachel , Singh Vinita , Karra Efthimia , Rosenthal Miranda , Yousseif Ahmed , Armeni Eleni

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence of the impact of BS on antenatal glycaemic control. We present three cases of pregnancy post-BS, who experienced various degrees of hypoglycaemia during gestation.Case presentations: Three women aged 25-, 26-, and 36-years-old, who were previously euglycaemic, presented to the joint antenatal clinic wi...

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ea0094p122 | Reproductive Endocrinology | SFEBES2023

Rare case of a steroid cell tumour causing hirsutism in a young girl

Amjad Wajiha , Krishnan Leena

Steroid cell tumours are very rare ovarian sex cord tumours that account for only < 0.1% of ovarian tumours. We present an interesting case of a steroid cell tumour in a 17 year old girl referred with worsening hirsutism, weight gain of nearly 3 stones and oligomenorrhea over 2 years. Menarche with regular menstrual cycles was attained at the age of 13 followed by normal reproductive development. On examination, she had an elevated BMI of 33.7 and there was marked hirsutis...

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ea0094p123 | Reproductive Endocrinology | SFEBES2023

Type 4 Perrault syndrome in males: Is there a reproductive phenotype?

Quinton Richard , Pearce Simon , McEleny Kevin , Wright Michael , Osman Omer , Chohan Muhammad

Introduction: Perrault syndrome (PS), a rare autosomal recessive condition mostly reported in females, is characterized by sensorineural hearing loss (SNHL), ovarian dysgenesis manifesting as primary amenorrhoea (PA), premature ovarian insufficiency (POI) and neurological manifestations but little is known about testicular function in males.Case summary: A 34 year-old man was referred with progressively reduced libido, e...

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ea0094p124 | Reproductive Endocrinology | SFEBES2023

Klinefelter syndrome in a resource-challenged setting: A case report

Soyoye David , Amodu Bosede , Adeyemi Taiwo , Adetunji Tajudin , Ikem Rosemary , Kolawole Babatope , Azeez Taoreed

Introduction: Klinefelter syndrome is the commonest sex chromosomal disorder in which the normal male karyotype 46XY, has at least one extra X chromosome. The commonest form is the 47XXY aneuploidy. It is characterized by hypergonatrophic hypogonadism, and associated with infertility and cardio-metabolic abnormalities. We report a case of a 36year old man who presented in our Endocrinology clinic in Ngeria.Case Presentation:</str...

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ea0094p258 | Reproductive Endocrinology | SFEBES2023

Significant weight loss associated with GLP1 receptor agonist use in obese women with polycystic ovary syndrome- a retrospective cohort study

Alawami Fatimah , Novaes Olivia , Gibney James , Phelan Niamh , Ann Behan Lucy , Owens Lisa

Introduction: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of obesity and weight gain. Obesity negatively impacts the fertility, mental wellbeing and long term health of women with PCOS. The 2023 international guidelines for the management of PCOS suggest that GLP1 receptor agonists could be considered, but highlight a lack of evidence for medical obesity treatment in women with PCOS. Previous studies showed that interventions which red...

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ea0094p259 | Reproductive Endocrinology | SFEBES2023

Abstract withdrawn...

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ea0094p260 | Reproductive Endocrinology | SFEBES2023

Ovarian mitochondrial dysfunction in letrozole-induced PCOS rat model: Therapeutic role of HDAC2 inhibition

S. Olaniyi Kehinde , E. Areloegbe Stephanie

Background: Androgen excess and metabolic abnormality largely contribute to the pathogenesis of PCOS, which primarily precipitates ovarian dysfunction and infertility in reproductive-age women. Impaired mitochondrial function and epigenetic alteration have been linked to the development of PCOS. However, the therapeutic potential of histone deacetylase (HDAC) inhibition on ovarian mitochondrial dysfunction is unclear, especially in PCOS is unclear. Herein, the...

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ea0094p261 | Reproductive Endocrinology | SFEBES2023

Gonadectomy in people with a difference of sex development: Initial data from an I-DSD registry prospective quality improvement study

Lucas-Herald Angela , Bryce Jillian , H Davies Justin , Shnorhavorian Margarett , Demir Korcan , de Vries Liat , Elsfedy Heba , Globa Evgenia , Grinspon Romina , Guerra-Junior Gil , Janus Dominika , Faisal Ahmed S , O'Connell Michele

Introduction: There is some variation in the practice of gonadectomy for individuals with Differences of Sex Development (DSD) worldwide. This quality improvement project aims to undertake continued surveillance of the occurrence of gonadectomy in suspected or confirmed cases of DSD.Methods: Participating centres from the International-DSD Registry are sent a monthly email asking if a gonadectomy has been performed. A se...

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ea0094p262 | Reproductive Endocrinology | SFEBES2023

Sex affects Ca²⁺ channel expression of adult inguinal fat adipocytes and their Ca²⁺ response to oxytocin: Roles in mammogenesis and function?

Smith Paul , Toledo-rodriguez Maria , Fedorenko Olena

Inguinal subcutaneous fat, the site of murine mammary glands 4 and 5, is a suitable model of mammary white fat adipose tissue (WAT). WAT requires extracellular Ca2+ influx for differentiation and expansion; this primarily occurs via plasma membrane Ca2+ voltage-dependent channels (CaVs). Whereas the neuropeptide oxytocin can mobilise intracellular Ca2+ in WAT which has key roles in lactation. Our aim was to use a combination of molecular biolog...

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ea0094p263 | Reproductive Endocrinology | SFEBES2023

A case of high testosterone in an asymptomatic female patient

Ahsan Masato , Zaman Sajnin , Saeed Mohamed , Gohil Shailesh , Reddy Narendra , Levy Miles

Introduction: Testosterone <5nmol/l is commonly seen in conditions such as PCOS however when testosterone is >5nmol/l, concerns start to rise about more sinister causes. Here, we present a case of a female who was referred to clinic with testosterone >5mmol/lCase: A 32 year old presented to the GP with a heavier than usual menstrual period. For an unknown reason, the GP checked testosterone, which came back a...

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ea0094p264 | Reproductive Endocrinology | SFEBES2023

Insights into dysregulation of luteinizing hormone receptor (LHR) signaling in granulosa lutein (GL) cells from women with polycystic ovary syndrome (PCOS)

Anujan Priyanka , Owens Lisa , Talwar Divreena , Hardy Kate , Hanyaloglu Aylin , Franks Stephen

Polycystic ovary syndrome (PCOS) is a multifactorial, complex endocrine disorder affecting a significant proportion of the global population. Aberrant secretion and/or action of gonadotropins is implicated in PCOS, but, to date, we have only limited knowledge about the precise mechanisms involved. We therefore studied LHR expression, signalling and trafficking in GLCs from women with and without PCOS. GLCs from women with PCOS exhibited enhanced Gαs-cAMP signalling respon...

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ea0094p265 | Reproductive Endocrinology | SFEBES2023

Non-invasive assessment of liver abnormalities in turner syndrome: A Follow-up Study

Calanchini Matilde , Shipley Alexandra , Cobbold Jeremy , Tomlinson Jeremy , Turner Helen

Background: We have previously reported abnormal liver function tests (LFTs), FIB-4 scores and liver stiffness measurements (LSM, Fibroscan) in patients with Turner syndrome (TS), but longitudinal data defining the impact of TS on liver phenotype are limited.Methods: We undertook a retrospective longitudinal follow-up audit (OUH; 8348) of 24 women with TS who had abnormal LFTs and underwent at least 2 assessments (median...

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ea0094p266 | Reproductive Endocrinology | SFEBES2023

The mystery of bulky testes

Thakkar Simran , Rai Pareekshith

A 7 year old boy presented with complaint of scrotal heaviness and swelling more on the right side. He had history of early and disorganised tanner pubertal growth pattern: development of axillary hair>penile enlargement>pubic hair >right testicular enlargement. On examination, he was found to have elevated blood pressure and bilateral testicles were enlarged (right>left) and non-tender. Based on these clinical findings, diagnosis of precocious puberty was susp...

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ea0094p267 | Reproductive Endocrinology | SFEBES2023

Kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Chia Eng Pei , Patel Bijal , Modi Manish , Young Megan , Papadopoulou Deborah , R Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare genetic disorder typically due to defective migration of olfactory-axons and GnRH-neurons. KS results in congenital hypogonadotrophic hypogonadism (CHH) typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilateral hypoplastic/absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Here, we present an unusual case of KS with unilateral anosmia....

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ea0094p268 | Reproductive Endocrinology | SFEBES2023

Simultaneous adrenal and ovarian vein sampling in the evaluation of androgen excess in women

Arshad Amynta , Elhassan Yasir , Gleeson Helena , Asia Miriam

Background: Most women with androgen excess have polycystic ovary syndrome (PCOS); however, rarer pathology is considered in a severe phenotype such as ovarian or adrenal androgen-producing tumours. Simultaneous adrenal and ovarian vein sampling is rarely performed to aid the localisation of the androgen excess source. We report four cases that underwent this procedure.Case descriptions: Case 1: A 27-yea...

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ea0094p269 | Reproductive Endocrinology | SFEBES2023

A case of postpartum hypophysitis initially treated as postpartum thyroiditis

Umair Shehzad Muhammad , Yee Sharlei , Abouglila Kamal

A 45 yr lady;presented with lethargy and tiredness, amenorrhea with 2 stone weight loss 3 months after delivery of her baby. Her thyroid functions were done showing low free T4 (0.28 mu/l) as well as low TSH (07 pmol/l). (Thought to be cooling off period of post-partum thyroiditis). She was started on Thyroid hormone replacement (levothyroxine 150 mg once a day) Reviewed again after a month in endocrine clinic, she still feeling tired, lethargic and unwell still not having per...

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ea0094p270 | Reproductive Endocrinology | SFEBES2023

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in pre-eclampsia: A rare case of hyponatraemia in pregnancy

Abdalraheem Ali , Banerjee Ritwik , Thong Lim Chung

Hyponatraemia in pregnancy can be precipitated by various factors, including drugs, fluid excess and oxytocin infusion. It is a common complication of pre-eclampsia toxaemia (PET), although concomitant syndrome of inappropriate ADH secretion (SIADH) in this context is rare. We present a case of SIADH leading to hyponatraemia in a PET patient. A 30 year-old primigravid woman with bipolar disorder and hypertension was admitted with pre-eclampsia at gestational week 28. Her medic...

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ea0094p271 | Reproductive Endocrinology | SFEBES2023

Are we paying enough attention to detect autoimmune hematological diseases in turner syndrome? Retrospective analysis of a clinic database from a single specialist center

G K Amiyangoda C , B A Roy Noemi , A D Mathara Diddhenipothage Shani , Shears Debbie , E Turner Helen

Introduction: There is limited literature on autoimmune haematological disorders (AIHD) such as autoimmune thrombocytopenia (ITP), autoimmune haemolytic anaemia, and autoimmune neutropenia (AN) in Turner syndrome (TS) although autoimmune disorders are more common in TS.Methodology: Retrospective analysis of a clinic database, to identify patients with AIHD out of all the patients followed up in a specialised TS clinic. (...

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ea0094p272 | Reproductive Endocrinology | SFEBES2023

Spurious elevation of serum alpha-fetoprotein level due to assay interference-challenges in managing discrepant results

Faraz Danish Alvi Syed , Zeitoon Sa'ed , Nag Sath

Introduction: Alpha-fetoprotein (AFP), produced by the yolk sac and liver, is the most abundant serum protein in the human foetus. In adults, elevated AFP maybe associated with germ-cell or non-germ cell tumours, gastrointestinal tumours, active liver disease and hepatocellular carcinoma. Our case illustrates diagnostic uncertainties due to persistently elevated AFP values in the absence of any obvious pathology. Case Presentatio...

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ea0094p273 | Reproductive Endocrinology | SFEBES2023

Severe postmenopausal hirsutism and virilization caused by a virilizing ovarian dermoid cyst

Zeitoon Sa'ed , Faraz Danish Alvi Syed , Hebblethwaite Neil , Nag Sath

Introduction: Ovarian dermoid cysts, also known as mature cystic teratomas, are a very rare cause of virilization. Virilization in such cases is usually secondary to Sertoli-Leydig tumours, Leydig cell hyperplasia or Sertoli cell tumour. In some cases, no clear explanation for hyperandrogenism is found. Surgical excision of dermoid cyst results in normalization of androgen levels and resolution of symptoms.Case Presentation:</str...

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ea0094p274 | Reproductive Endocrinology | SFEBES2023

Clinical data suggesting variable dynamics between BMI, LH/FSH ratio and FSH alone in a cohort of patients with polycystic ovary syndrome

Mann-Wineberg Dania , Solomon Andrew

Background: Polycystic Ovary Syndrome (PCOS) is characterized as a triad of menstrual irregularities, hyperandrogenism and polycystic ovarian morphology. There is a wide variation in Body Mass Index (BMI) for those fitting PCOS criteria; Identifying differences in relation to Lean BMI patients endocrine markers such as LH/FSH ratio and other markers could help identify key areas for improved phenotypic classification. We aimed to focus on a sequential co...

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ea0094p275 | Reproductive Endocrinology | SFEBES2023

Any place for testosterone replacement therapy in functional hypogonadism? A case report

Olopade Oluwarotimi , Ede Obiamaka , Udo Chinyere , Odeniyi Ifedayo , Fasanmade Olufemi

Introduction: Functional Hypogonadism (FH) is a condition with low circulating serum testosterone and an intact Hypothalmo-pituitary-gonadal axis. The use of testosterone replacement therapy (TRT) use in FH is controversial based on the risk-benefit ratio. This report highlights the benefits of managing FH with TRT. Case Presentation: 47-year-old man presented to the endocrine clinic on account of poor erection, reductio...

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ea0094p375 | Reproductive Endocrinology | SFEBES2023

An unusual case of azoospermia

Lee Yoong Zher Melvin

Leydig cell tumors are a rare form of hormonally active testicular tumors. They often present as a painless testicular mass. Infertility as the primary presentation is rare in this condition. A 32 year old man, presented with symptoms of infertility and hypogonadism which had occurred over a period of 1 year. He however was found to have a raised testosterone and estradiol levels as well as suppressed gonadotrophin levels. The patient had a historic sperm analysis done 2 years...

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ea0094p376 | Reproductive Endocrinology | SFEBES2023

Endocrinological alterations in patients with hiv infection, analysis between variables of a latin american hospital

Ciliberti Maria , Dulcey Luis , Theran Juan , Gomez Jaime , Blanco Edgar

Background: Study the frequency of thyroid, adrenal, and gonadal dysfunction in HIV-infected patients and correlate them with CD4 cell count levels. Design: Cross-sectional study of 760 HIV-infected adults. in the period from January 2016 to December 2018.Methodology: Free T3, free T4, TSH, Cortisol, FSH, LH, testosterone and estradiol were estimated by the radioimmunoassay method. Hormone levels and their correlation wi...

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ea0094p377 | Reproductive Endocrinology | SFEBES2023

Hypoglycaemia in pregnancy post bariatric surgery: A case series

Narunsky Rachel , N Ali Sarah , Singh Vinita , Karra Efthimia , Rosenthal Miranda , Yousseif Ahmed , Armeni Eleni

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence on the impact of BS on antenatal glycaemic control. We present four cases of pregnancy post-BS, reviewed in the joint antenatal clinic, who experienced various degrees of hypoglycaemia during pregnancy.Case presentations: Four pregnant women (cases AD, aged 2536-years-old, 38years pos...

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ea0094p378 | Reproductive Endocrinology | SFEBES2023

Circadian and post-glucose load changes in salivary testosterone concentration

Fenn Jonathan , Gill Henry , Starbrook Lauren , Sharrod-Cole Hayley , Kalaria Tejas , Ford Clare , Gama Rousseau

Background: The diagnosis of male hypogonadism can be difficult. Free testosterone is calculated if total testosterone is close to the lower limit of normal, however, this is inaccurate in conditions that alter sex-hormone-binding globulin. Alternatively, salivary testosterone is thought to reflect free testosterone, but is present at low concentrations, thus requiring sensitive mass spectrometry instrumentation, and there is limited data on the pre-analytical...

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ea0094p379 | Reproductive Endocrinology | SFEBES2023

Protective effects of Betanin against noise and scrotal hyperthermia on testicular toxicity in wistar rats: Role of oxidative stress, apoptosis, and inflammation

Bijani Soroush , Hosseini Mir-Jamal , Naserzadeh Parvaneh

The present study was conducted to investigate the signaling pathway involved in betanin against noise and scrotal hyperthermia and to clarify whether it affects oxidative stress, apoptosis and inflammation in testis of rats. Scrotal hyperthermia was induced by heat exposure of rat testicular for 43ºC for 15 min (3 times per weeks for 14 days). Noise induction was done following exposure of rats with 100 decibel noise level for 14 day and 8 h daily similar to real conditi...

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ea0094p380 | Reproductive Endocrinology | SFEBES2023

Development of an LC-MS/MS assay for seven salivary steroids including the 11-oxygenated androgens

McTaggart Malcolm , Hawley James , Keevil Brian

For several years, steroid hormones including testosterone (T), androstenedione (A4) and 17-hydroxyprogesterone (17-OHP) have been utilised in the diagnosis of a range of conditions with clinical features of hyperandrogenaemia including polycystic ovary syndrome (PCOS) and congenital adrenal hyperplasia. In recent years a potential role for the 11-oxygenated androgens has emerged in the diagnosis and characterisation of androgenic disorders. Specifically, the 11-oxygenated and...

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Society for Endocrinology BES 2023

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