Endocrine Abstracts

People are all different, and this is no different when we consider people with diabetes, yet the current approaches to management of diabetes tend to treat everyone the same. The field of precision medicine aims to recognise these differences – whether at the level of their phenotype or at the molecular level. Faced with multiple, and increasing, treatment options for diabetes as well as increasing healthcare costs there is a clear need to target therapy to maximise benefit and reduce harm for every patient with diabetes. This talk will discuss advances in precision medicine and pharmacogenetics in diabetes. I will highlight recent work on how phenotypic variation matters, and how this maps to genetic variation, and will provide an overview of how genetic variants alter glycaemic response to commonly used diabetes drugs and how these inform on disease and drug mechanism. I will finish with an overview of iDiabetes – an intelligent diabetes platform that we will be using to implement precision diabetes care in Tayside in 2024.