Endocrine Abstracts

Adipocytes are important metabolic buffers and endocrine regulators of energy expenditure and satiety. Adipocyte dysfunction, either genetic or as observed in acquired obesity, is linked to hallmarks of the metabolic syndrome. I will discuss novel translational regulators of adipocyte function and focus on the role of the proteasome for cellular protein quality control, ER stress, and maintenance of healthy brown and white adipocytes in obesity, diabetes, and atherosclerosis in cells, transgenic mice, and humans.