Endocrine Abstracts

Ageing is an inevitable biological process that affects all aspects of human physiology including reproductive health. While much attention has been devoted to the age-related decline in female fertility, the impact of ageing on male reproduction is perhaps less well appreciated. This presentation aims to provide a concise overview of the relationship between ageing and sperm health, highlighting key findings and implications. Ageing has a significant impact on sperm health and male fertility. As men age, sperm quality and function decreases, including poorer sperm motility and an increase in DNA damage and abnormal sperm morphology. These changes are believed to be linked to a variety of factors, such as increased oxidative stress and reduced antioxidant defence, as well hormonal changes associated with ageing. Importantly, age-related changes in sperm can have profound consequences for male fertility. Advanced paternal age has been associated with longer time to conception and increased risk of infertility as well as higher likelihood of pregnancy complications. Moreover, older fathers may transmit genetic mutations and epigenetic changes to their offspring, contributing to a range of health issues in the offspring. In an era when couples are delaying parenthood, education and awareness of the implications of ageing on male fertility are of paramount importance. Understanding the impact of ageing on sperm health is crucial for healthcare providers, researchers, couples seeking to conceive, as well as for public health.