Searchable abstracts of presentations at key conferences in endocrinology
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26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

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We are pleased to announce that ECE 2024 will be held in Stockholm, Sweden from 11-14 May 2024. We will, once again, be offering the hybrid format next year so you can join us in person in Sweden or remotely with ECE@Home.

Oral Communications

Oral Communications 1: Reproductive and Developmental Endocrinology

ea0099oc1.1 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Hypospadias is linked to genetic susceptibility to the environment through oncogenes and its incidence is geographically correlated to that of cancers worldwide

Kalfa Nicolas , Bergougnoux Anne , Philibert Pascal , Servant Fauconnet Nadege , Faure Alice , Breaud Jean , Gaspari Laura , Sultan Charles , Paris Francoise

Background: The etiology of hypospadias may be at the crossroad of genetics and environment. The study of these factors taken individually failed to find an unequivocal explanation in most cases. But the interactions between exposure to endocrine disruptors chemicals (EDC) and genetic background have not yet been studied. We thus aimed to find a genetic susceptibility to the environment in hypospadias.Methods: Through a multicenter prospective comparativ...

ea0099oc1.2 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Mortality among women with POI, nationwide register based case-control study

Haapakoski Hilla , Silven Heidi , Pesonen Paula , Savukoski Susanna , Niinimaki Maarit

Introduction/Purpose: Despite some evidence that women with premature ovarian insufficiency (POI, loss of ovarian activity<40 years of age) are at risk for diminished life expectancy, large scale population-based studies are still scarce. The evidence on whether hormone replacement therapy (HRT) use decreases the mortality risk among women with POI are lacking. The aim of our study was to explore mortality among women with spontaneous POI and their controls in a large nati...

ea0099oc1.3 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Pregnancy loss in women with endocrine disorders – a nationwide registry-based cohort study of 366,548 Danish women

Egerup Pia , Bliddal Sofie , Westergaard David , Glintborg Dorte , Bonnema Steen J. , Feldt-Rasmussen Ulla , Nyegaard Mette , Mortensen Laust Hvas , Svarre Nielsen Henriette

Background: Pregnancy loss affects approximately 25% of pregnancies, of which 40% have no detectable chromosome abnormalities and are suspected to be caused by maternal comorbidity. Pregnancy loss has been associated with specific endocrine disorders, e.g. autoimmune thyroid disease (AITD), polycystic ovarian syndrome (PCOS) or diabetes mellitus (DM). Because of the well-described overlap between these endocrine disorders, we hypothesized that pregnancy loss is associated with...

ea0099oc1.4 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Kisspeptin as a test of hypothalamic function in women presenting with oligo / amenorrhoea

Patel Bijal , Abbara Ali , Yeung Arthur , Phylactou Maria , Tsoutsouki Jovanna , Koysombat Kanyada , Young Megan , Nyunt Sandhi , Qayum Ambreen , Patel Aaran , Zielinska Agata , Omar Yusra , Eng Pei , Mills Edouard G , Hanassab Simon , Webber Lisa , Jayasena Channa , Tan Tricia , Quinton Richard , Clarke Sophie , Comninos Alexander , Dhillo Waljit

Background: Polycystic Ovary Syndrome (PCOS) and Functional Hypothalamic Amenorrhoea (FHA) are the two commonest causes of menstrual disturbance in pre-menopausal women. In practice, differentiating these two common reproductive disorders can be challenging. A fundamental abnormality that underpins both conditions is altered gonadotrophin releasing hormone (GnRH) pulsatility, being increased in PCOS but reduced in FHA. Likewise, congenital (e.g. congenital hypogonadotropic hyp...

ea0099oc1.5 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Gender affirming treatment and employment rate in 3,812 Danish transgender persons and 38,120 controls. A nationwide register-based cohort study

Glintborg Dorte , Moller Jens-Jakob , Rubin Katrine , Lidegaard Ojvind , T'Sjoen Guy , Larsen Mie-Louise , Hilden Malene , Andersen Marianne

Objective: Transgender persons often experience low socioeconomic status. Gender affirming treatment aims to improve gender dysphoria. We assessed employment rates in transgender persons compared to controls and demographic, health and treatment-related factors associated with unemployment in transgender persons.Methods: National register-based cohort study in Danish transgender persons with diagnosis code of gender identity disorder during year 2000-202...

ea0099oc1.6 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Sertoli cell function and the dose of denosumab is critical for the response to RANKL inhibition in human testis cultures

Andreassen Christine Hjorth , Krarup Knudsen Nadia , Erik Nielsen John , Kafai Yahyavi Sam , Holt Rune , Jorgensen Anne , Blomberg Jensen Martin

Currently, no treatment options exist to improve semen quality for the majority of infertile men, but it is well known that the interaction between Sertoli- and germ cells is essential to ensure complete spermatogenesis. A recent study suggested that denosumab, an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL) signaling, may decrease germ cell apoptosis in human ex vivo testis cultures and stimulate sperm production in some infertile men. Her...