Endocrine Abstracts

Background: The etiology of hypospadias may be at the crossroad of genetics and environment. The study of these factors taken individually failed to find an unequivocal explanation in most cases. But the interactions between exposure to endocrine disruptors chemicals (EDC) and genetic background have not yet been studied. We thus aimed to find a genetic susceptibility to the environment in hypospadias.Methods: Through a multicenter prospective comparativ...

Introduction/Purpose: Despite some evidence that women with premature ovarian insufficiency (POI, loss of ovarian activity<40 years of age) are at risk for diminished life expectancy, large scale population-based studies are still scarce. The evidence on whether hormone replacement therapy (HRT) use decreases the mortality risk among women with POI are lacking. The aim of our study was to explore mortality among women with spontaneous POI and their controls in a large nati...

Background: Pregnancy loss affects approximately 25% of pregnancies, of which 40% have no detectable chromosome abnormalities and are suspected to be caused by maternal comorbidity. Pregnancy loss has been associated with specific endocrine disorders, e.g. autoimmune thyroid disease (AITD), polycystic ovarian syndrome (PCOS) or diabetes mellitus (DM). Because of the well-described overlap between these endocrine disorders, we hypothesized that pregnancy loss is associated with...

Background: Polycystic Ovary Syndrome (PCOS) and Functional Hypothalamic Amenorrhoea (FHA) are the two commonest causes of menstrual disturbance in pre-menopausal women. In practice, differentiating these two common reproductive disorders can be challenging. A fundamental abnormality that underpins both conditions is altered gonadotrophin releasing hormone (GnRH) pulsatility, being increased in PCOS but reduced in FHA. Likewise, congenital (e.g. congenital hypogonadotropic hyp...

Objective: Transgender persons often experience low socioeconomic status. Gender affirming treatment aims to improve gender dysphoria. We assessed employment rates in transgender persons compared to controls and demographic, health and treatment-related factors associated with unemployment in transgender persons.Methods: National register-based cohort study in Danish transgender persons with diagnosis code of gender identity disorder during year 2000-202...

Currently, no treatment options exist to improve semen quality for the majority of infertile men, but it is well known that the interaction between Sertoli- and germ cells is essential to ensure complete spermatogenesis. A recent study suggested that denosumab, an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL) signaling, may decrease germ cell apoptosis in human ex vivo testis cultures and stimulate sperm production in some infertile men. Her...