Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 99 | ECE2024 | Next issue

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

Card image cap
We are pleased to announce that ECE 2024 will be held in Stockholm, Sweden from 11-14 May 2024. We will, once again, be offering the hybrid format next year so you can join us in person in Sweden or remotely with ECE@Home.

ea0099p155 | Thyroid | ECE2024

Low TPO-antibody titers appear to promote aggressive thyroid cancers tumorigenesis: analysis of a large multinational dataset

Paparodis Rodis , Karvounis Evaggelos , Kapezanou Aikaterini , Bantouna Dimitra , Livadas Sarantis , Simeakis George , Askitis Dimitrios , Androulakis Ioannis , Angelopoulos Nicholas , Zianni Dimitra , Perogamvros Ilias , Boniakos Anastasios , Rizoulis Andreas , Imam Shanawaz , Carlos Jaume Juan

Introduction: In the thyroid gland, humoral immunity manifests with thyroid peroxidase (TPO) antibodies. In our studies, when TPO concentrations increased, thyroid cancers of follicular origin (TCFO) tended to develop less frequently.1 Other studies, though, reported an opposite trend in less aggressive cancers. The present work was designed to characterize the differential role of TPO antibodies in aggressive forms of TCFO (AGG) as compared to non-aggressive (NAG) ...

ea0099p156 | Thyroid | ECE2024

Thyroid hormone transporter Mct8/Oatp1c1 deficient mice display impaired CNS capillary network formation

Markova Boyka , Alevyzaki Androniki , Spangenberg Philippa , Robert Engel Daniel , Mayerl Steffen , Heuer Heike

The thyroid hormone (TH) transporters Mct8 (encoded by Slc16a2) and Oatp1c1 (encoded by Slco1c1) are critically involved in mediating TH passage across mouse brain barrier cells. Mct8/Oatp1c1 deficient mice (= DKO mice) exhibit a strongly reduced brain TH content and consequently, an impaired neuronal development and hypomyelination all of which are also seen in patients with MCT8 deficiency (Allan-Herndon-Dudley Syndrome, AHDS). Our recent studies of mouse mutants lacking bot...

ea0099p157 | Thyroid | ECE2024

Plasmablastic lymphoma presenting as a rapidly increasing thyroid mass: a case report

Paschalidi Charikleia , Fountas Athanasios , Markou Athina , Vlachou Charikleia , Efthymia Bazani , Gorgolidis Georgios , Sassi Marina , Nitsios Ioannis , Liokati Ioanna , Papastergiou George , Papanastasiou Labrini

Introduction: Primary thyroid lymphoma is a rare entity accounting for <5% of thyroid malignancies and <2% of extra-nodal lymphomas with diffuse large B-cell lymphoma (DLBCL) being the most common subtype. Plasmablastic lymphoma (PBL) is an uncommon and aggressive subtype of DLBCL mainly detected in patients with immunosuppression, especially related to HIV infection. Typically, PBL occurs in extra-nodal sites, usually the oral cavity and the gastrointestinal tract whi...

ea0099p158 | Thyroid | ECE2024

Subacute thyroiditis in the SARS-Cov-2 era: a multicenter prospective study

Sueri Roberta , De Vincentis Sara , Loiacono Simona , Zanni Eleonora , Laura Monzani Maria , Santi Daniele , Muller Ilaria , Di Marco Francesco , Crivicich Erica , Pagotto Uberto , Cecchetti Carolina , Tucci Lorenzo , Simoni Manuela , Brigante Giulia

Introduction: Several cases of subacute thyroiditis (SAT) have been described in patients with SARS-CoV-2. However, no prospective data about follow-up in SARS-CoV-2-related SAT are known.Aim: The characterization of clinical peculiarities and response to medical treatment of SAT cases, correlating to virus exposure, ascertained with antibody (Ab) dosage.Methods: A prospective, 3-years, multicentre study was conducted, enrolling pa...

ea0099p159 | Thyroid | ECE2024

Transcriptomic characterization of single cells derived from immortalized human thyroid follicular epithelial cell lines

Wittner Leonie , Schnapp Marie , Busche Tobias , Feldkamp Joachim

Immortalized human thyroid follicular epithelial cell lines represent a valuable tool for the investigation of thyroid physiology in vitro. While there is an extensive selection of human thyroid carcinoma cell lines, the number of healthy follicular epithelial cell lines is limited. The vast majority of studies on thyroid physiology is based on the human immortalized cell line Nthy-ori 3-1, leading to comprehensive characterization of this cell line. However, in 2021 ...

ea0099p160 | Thyroid | ECE2024

New plasma biomarkers: XIAP and survivin in patients with medullary thyroid cancer (MTC)

Glinicki Piotr , Szatko Alicja , Żyłka Agnieszka , Długosińska Joanna , Ostrowska Magdalena , Gietka-Czernel Małgorzata , Ratajczak Maciej , Zgliczyński Wojciech , Dedecjus Marek

Introduction: Medullary thyroid carcinoma (MTC) constitutes 3.5-5% of all thyroid cancers. Routine biochemical diagnostics include determination of calcitonin (CT), procalcitonin (PCT) and carcinoembryonic antigen (CEA). XIAP (X-linked inhibitor of apoptosis protein) and survivin belong to the family of proteins – inhibitors of apoptosis (IAP). Using tissue microarrays, the expression levels of XIAP and survivin were tested in patients with medullary thyroid cancer. The s...

ea0099p161 | Thyroid | ECE2024

Differentiated thyroid cancer in pregnancy. A retrospective analysis of newly diagnosed patients

Bulwa Maciej , Samborski Konrad , Kolton Magdalena , Haras-Gil Malgorzata , Jarzab Barbara , Handkiewicz-Junak Daria , Krajewska Jolanta

Introduction: The question of whether pregnancy has any impact on the prognosis of differentiated thyroid cancer diagnosed in pregnant women was addressed mainly in retrospective analyses, which showed no significant differences in overall and progression-free survival between women diagnosed during pregnancy in comparison to women whose thyroid cancer diagnosis was unrelated to pregnancy. Thus, following the recent guidelines, watchful waiting is the preferred option, and sur...

ea0099p162 | Thyroid | ECE2024

Falsely elevated thyroid function tests due to laboratory interference

Drugda Jan , Gabalec Filip , Hyšpler Radomir

Introduction: Thyroid function tests (thyroid hormones and thyreotropin) are frequently used by physicians all over the world. The interpretation is usually quite simple and straight-forward, however sometimes there is a strange discrepancy between the laboratory findings and clinical presentation. There are several potential explanations to this discrepancy and interference in laboratory assay may be one of them.Observation: We present a case of a 73-ye...

ea0099p163 | Thyroid | ECE2024

The effect of monoclonal antibodies alemtuzumab and ocrelizumab on the thyroid function of patients with multiple sclerosis

Kazakou Paraskevi , G Vakrakou Aigli , Tzanetakos Dimitrios , S Tzartos John , Anagnostouli Maria , Stathopoulos Panos , Dermentzoglou Alexandros , N Kassi Georgia , Kilidireas Constantinos , Zapanti Evangelia

Aim: Autoimmune thyroid disease (AITD) is the most common adverse effect in alemtuzumab (ALZ) treated relapsing–remitting (RR) multiple sclerosis (MS) patients. The objective of this prospective study was to analyze the occurrence, timing of onset, clinical course, and laboratory characteristics of AITD post-ALZ and subsequently the clinical outcome of AITD post-ALZ in patients who received ocrelizumab.Patients and methods: We evaluated 36 RRMS pati...

ea0099p164 | Thyroid | ECE2024

High local and systemic expression of pentraxin-3 in anaplastic thyroid cancer

Bojoga Andreea , van Houten Pepijn , Jaeger Martin , Rabold Katrin , Ioachim Dumitru , Walgreen Birgitte , van Emst Liesbeth , Badiu Corin , Teodora Netea-Maier Romana

Introduction: Long pentraxin 3 (PTX3), a protein cells produce in response to several inflammatory stimuli, is essential in innate immunity, controlling inflammation, tissue remodeling, and cancer dynamics. PTX3 promotes the migration and invasion of cells in different tumor models. This study aims to (I) immunohistochemically assess the presence and distribution of PTX3 in tissue samples from non-medullary thyroid cancer (NMTC) and (II) (TC) to determine the differences of ci...

ea0099p165 | Thyroid | ECE2024

Clinical and histopathological factors associated with the prognosis of medullary thyroid cancer in a tertiary center

Martins Ferreira Mafalda , Carvalho Tania , Madeira Joana , Lopes Sofia , Melo Miguel , Ribeiro Cristina , Saraiva Joana , Oliveira Patricia , Paiva Isabel

Introduction: Medullary thyroid cancer (MTC) is a rare tumour. Mostly sporadic, 25% are associated with multiple endocrine neoplasia (MEN2A/B) or isolated familial MTC. Surgery is the only curative option: its response is defined as complete (no evidence of biochemical or structural disease), incomplete (only structural response) and persistence of structural disease. We aimed to analyse the clinical and pathological factors associated with the prognosis of MTC.<p class="a...

ea0099p166 | Thyroid | ECE2024

Graves’ disease relapse after 30-year remission in a female patient due to SARS-CoV-2 infection- a case report

Askitis Dimitrios

Introduction: COVID-19 has been established as a multisystemic disease with the potential of affecting all the organs of the human organism including the thyroid gland which features ACE2 receptors for the cellular entry of SARS-CoV-2. Graves’ disease comprises the most common cause of thyrotoxicosis, manifests in genetically predisposed individuals with an autoimmune background and may be triggered by a variety of environmental factors, including viral infections. A few ...

ea0099p167 | Thyroid | ECE2024

Characterizing TSH-receptor antibody (TRAb) seropositive and TRAb seronegative patients with Graves hyperthyroidism - a cross-sectional study

Mifsud Simon , Gauci Zachary , Vella Sandro

Background: The concept of autoantibody-negative Graves’ disease (GD) is a subject of debate. Studies have revealed that autoantibody-negative GD does exist, albeit rare.1Method: Over a 3-year period, a total of 108 hyperthyroid patients who exhibited diffuse or normal thyroid uptake on thyroid scintigraphy, were assessed in a cross-sectional study. The thyroid function tests, TSH-receptor antibody (TRAb) levels, anti-thyroid peroxidase (anti-TPO) a...

ea0099p168 | Thyroid | ECE2024

Thyrotoxicosis and thyrotoxic periodic paralysis in hong kong: a population-based cohort study

Hoi-yee Li Gloria , Tang Ching-Man , Shing-Hin Li Ray , Wan Xiaoyu , Choon-Beng Tan Kathryn , Yun-Ning Cheung Elaine , Cheung Ching-Lung

Background: Thyrotoxic periodic paralysis (TPP) is a rare complication of thyrotoxicosis, characterized by recurrent hypokalemia, episodic muscle weakness and paralysis. It is potentially fatal in serious attacks with occurrence of life-threatening cardiopulmonary complications. Currently, lack of large cohorts comprising individuals with TPP history restrict the conduct of relevant epidemiology study.Methods: Clinical data from a population-wide electro...

ea0099p169 | Thyroid | ECE2024

Determination of the relationship between the development of persistent hypothyroidism after subacute thyroiditis and subtypes of human leukocyte antigen

Nur Korkmaz Fatma , Sahin Mustafa , Dalva Klara

Introduction: Subacute thyroiditis (SAT) can often resolve completely; however, it has been observed that in 11.6% of patients, permanent hypothyroidism (PHT) may develop the follow-up after diagnosis. Various studies have explored the relationship between thyroid volume at the time of diagnosis, post-treatment changes in thyroid volume, steroid therapy, and the development of PHT following SAT. While some studies suggest associations, there are also data indicating that no si...

ea0099p170 | Thyroid | ECE2024

Reference range and determinants of serum thyroglobulin in southwestern greece

Markantes Georgios , Armeni Anastasia , Bountouris Panagiotis , Chartoumpekis Dionysios , Mamali Irene , Kioutsioukis Ioannis , Michalaki Marina

Background: Thyroglobulin (Tg) is a protein exclusively synthesized by follicular thyroid cells. Serum Tg levels depend on thyroid volume, serum TSH levels, gender, age, smoking, and iodine intake. Consequently, serum Tg reference range may exhibit variations among different populations. It is crucial to establish population-specific reference ranges, especially when interpreting serum Tg values in the follow-up of patients with differentiated thyroid cancer who have undergone...

ea0099p171 | Thyroid | ECE2024

Diagnosis of medullary thyroid microcarcinoma by calcitonin measurement in fine-needle aspiration washout

Radu Ditescu Bogdan , Diana-Simina Luca , Andrei Stan , Andra Caragheorgheopol , Dana Terzea , Dan Alexandru Niculescu , Cătălina Poiană

Introduction: Medullary thyroid carcinoma (MTC) is an uncommon thyroid malignancy arising from calcitonin-producing parafollicular cells. Micro-MTC is defined traditionally as MTC that measures ≤1 cm and represents a very rare entity. Ultrasound-guided fine-needle aspiration biopsy cytology (FNAB-C) sensitivity is about 63% for MTC and can be improved by measurement of calcitonin in the needle washout (FNA-CT). The value of FNA-CT in micro-MTC has not been studied. Our a...

ea0099p172 | Thyroid | ECE2024

Safety of primary care-led surveillance for low-risk thyroid cancer patients

Eni Gedoni , Malik Mohamed

Background: Post-treatment monitoring of thyroid cancer depends on risk stratification for future recurrence or possible extra-thyroidal metastasis. Current guidance suggests that patients with favourable prognostic factors and a low likelihood of recurrence can be effectively monitored in community settings. This study explores the safety of community-based surveillance for stable low-risk thyroid cancer patients discharged from specialised thyroid clinic.<p class="abstex...

ea0099p173 | Thyroid | ECE2024

Thyroid health in inflammatory bowel disease

Sami Guzel Suleyman , Numan Demir Ahmet , Eskazan Tugce , Ibrahim Hatemi Ali , Sait Gonen Mustafa

Aim: Changes in thyroid functions, parenchymal structure and increased frequency of thyroid diseases in inflammatory bowel diseases(IBD) have been described in various studies. In the literature, studies using the data scanning method, most of which belong to the past period, stand out. In this study, we wanted to investigate the relationship between IBD and thyroid diseases in a non-retrospective study. The aim of this study is to systematically check whether there is a relat...

ea0099p174 | Thyroid | ECE2024

Changes of lipid profile in subclinical hyperthyroidism and following restoration of euthyroidism

Kaminski Grzegorz , Szczepanek - Parulska Ewelina , Olejarz Michał , Ruchała Marek , Saracyn Marek

Background: The impact of subclinical hyperthyroidism (sHT) on lipids concentration is still unclear. The aim of the study was to prospectively evaluate the changes in lipid profile in patients with sHT and following restoration of euthyroid state.Patients and methods: The studied group consisted of 44 patients (37 females, 7 males), diagnosed with endogenous sHT in the course of either toxic multinodular goiter, diffused thyroid autonomy or autonomously...

ea0099p367 | Thyroid | ECE2024

ALK fusion genes in a large cohort of thyroid carcinomas

Bulanova Barbora , Kuklikova Vlasta , Mastnikova Karolina , Vaclavikova Eliska , Carkova Jitka , Vlcek Petr , Lastuvka Petr , Katra Rami , Bavor Petr , Kodetova Daniela , Chovanec Martin , Drozenova Jana , Astl Jaromir , Soukup Jiri , Vcelak Josef , Bendlova Bela

Objectives: ALK fusion genes are a rare genetic alteration and have been described in various t types of thyroid carcinomas, particularly in papillary thyroid carcinomas (PTCs), poorly differentiated thyroid carcinomas (PDTCs) and anaplastic thyroid carcinomas (ATCs). The aim of this study was to identify ALK fusion genes in thyroid carcinoma samples, correlate them with clinical and histopathological features, and determine the prognostic significance of <em...

ea0099p368 | Thyroid | ECE2024

Long-term gene expression changes in the rat thyroid by neonatal irradiation - a possible mechanism related to thyroid carcinogenesis by childhood radiation

Fujimoto Nariaki , Matsuu-Matsuyama Mutsumi , Nakashima Masahiro

Introduction: Radiation exposure at young ages is a risk of thyroid cancer. Although early studies of the infants treated with X-rays already indicated an association, the risk became well-known by a rapid rise in childhood thyroid cancer cases after the Chernobyl nuclear plant accident. Human cases have been investigated extensively, but the underlying mechanisms have yet to be elucidated. Our previous investigation in rats found that neonatal X-irradiation induced long-term ...

ea0099p369 | Thyroid | ECE2024

The association of gestational thyroid function and thyroid autoimmunity with offspring neurodevelopment: an individual participant meta-analysis

Osinga Joris , Warringa Leonie , on Thyroid and Pregnancy Consortium , Peeters Robin , Korevaar Tim

Objective: Adequate thyroid hormone availability is essential for foetal neurodevelopment. While overt maternal hypothyroidism is associated with lower offspring IQ, recent studies suggested an inverse U-shaped association, with suboptimal offspring neurodevelopment for both the lower and higher thyroid function range. Our aim is to investigate the association of gestational thyroid function with offspring IQ scores, assess if this association is different based on the gestati...

ea0099p370 | Thyroid | ECE2024

Clinical value of reverse triiodothyronine in the identification of euthyroid sick syndrome and prediction of mortality in critically ill patients

Xu Shaoyong , Zeng Jingjing

Background: Elevated reverse triiodothyronine (rT3) is a characteristic feature of euthyroid sick syndrome (ESS), which is associated with mortality in critical patients. However, the lack of reference values limits the use of rT3 for ESS diagnosis and the prognostic value of rT3 is unclear. This study aimed to determine the reference range of rT3 in the ESS identification and mortality prediction in critically ill patients.Methods: This ongoing prospect...

ea0099p371 | Thyroid | ECE2024

Papillary thyroid cancer and body mass index: the role of mitochondrial arginase-2 in tumor microenvironment

Sparavelli Rebecca , Signorini Francesca , Giannini Riccardo , Marchetti Elio , Santini Ferruccio , Basolo Alessio , Ugolini Clara

Background: Papillary thyroid cancer (PTC) is a disease with an indolent course, excellent overall prognosis and long-term survival. However, some PTCs are associated with an increased risk of recurrent disease and aggressive behaviour. Many exogenous factors, as obesity, could be implicated in the pathogenesis of thyroid cancer but the biological mechanisms that may explain this connection have been only partially described. Potentially factors that combine overweight with th...

ea0099p372 | Thyroid | ECE2024

Diagnosis and therapy of medullary thyroid cancer. A real-life, retrospective, multicentric, Hungarian study

Reti Zsuzsanna , Tőke Judit , Balla Reka , Reismann Peter , Attila Kovacs Kristof , Sapi Zoltan , Bodor Miklos , Nagy Endre , Ivanyi Gabor , Valkusz Zsuzsanna , Mezosi Emese , Toth Miklos

Introduction: Medullary thyroid cancer (MTC) is a rare thyroid neoplasm arising from parafollicular C-cells secreting calcitonin. Although it possesses specific histological and biochemical markers, real-life diagnosis and management remain challenging.Aim: A retrospective analysis of MTC patients from four Hungarian endocrine university centres over 23 years (2000-2023) was undertaken. Demographic data and biochemical markers, staging, germ-line RET mut...

ea0099p373 | Thyroid | ECE2024

Women-specific reference ranges for serum TSH in Liguria: the impact of age and time of collection in a single-centre cross-sectional study

Giusti Massimo , Sidoti Marilena

Background: TSH is the first-line test for thyroid function. Since the 1990s, 3rd-generation assays have been available on automated platforms, and the normal ranges provided by manufacturers are generally used in diagnoses. In the age of gender medicine there is a need to refine normal TSH ranges. The aim of this study was to construct a normal TSH range in women living in our district.Methods: From 2005 to 2020, 4544 records from women under...

ea0099p374 | Thyroid | ECE2024

Adolescent with multiple benign skin lesions, cutaneous angiosarcoma and multiple thyroid nodules. what is the diagnosis?

Dikaiakou Eirini , Magkou Evgenia , Servitzoglou Marina , Vakaki Marina , Makrythanasis Periklis , Rachel Synodinou-Traeger Joanne , Marinakis Nikolaos , Gkeli Myrsini , Skondras John , Baka Margarita , Vlachopapadopoulou Elpis

Objective: To present the rare case of a patient with cutaneous angiosarcoma, multiple benign skin lesions together with multiple thyroid nodules and to discuss his genetic diagnosis.Case Presentation: A 132/12 years-old boy was referred to the Endocrinology department, following chemotherapy and radiotherapy. His medical history was uneventful until the age of 8 years. His mother reported Graves’ disease and his maternal grandmother papi...

ea0099p375 | Thyroid | ECE2024

Complications associated with the performance of thyroidectomies in a third-level hospital

Gomez-Gordo Hernanz Monica , Collado Gonzalez Gloria , Garcia Piorno Alberto , Losada Gata Isabel , Perez Noguero Marta , Jimenez Hernando Ignacio , Farache Suberviola Blanca , Morales Jaurrieta Amaya , Lopez Guerra Aurelio , Gonzalez Albarran Olga

Introduction: major complications of thyroid surgery include; injury to the recurrent laryngeal nerve that can cause dysphonia and acute respiratory distress, postsurgical hematoma, infection and hypoparathyroidism, which can be transient or permanent.Objective: to analyze the complications observed after performing thyroid surgery with different pre-surgical diagnoses in our center.Methods: retrospective descriptive study of thyro...

ea0099p376 | Thyroid | ECE2024

PTEN variants in thyroid tumors of czech patients

Mastnikova Karolina , Bulanova Barbora , Kuklikova Vlasta , Vaclavikova Eliska , Carkova Jitka , Hrckulakova Karolina , Katra Rami , Vlcek Petr , Kodetova Daniela , Chovanec Martin , Drozenova Jana , Matej Radoslav , Astl Jaromir , Hlozek Jiri , Soukup Jiri , Vcelak Josef , Bendlova Bela

Objectives: Phosphatase and tension homolog (PTEN) is a part of signal pathways which are essential for cell proliferation, cell cycle progression, and apoptosis. Variants in the PTEN gene occur in different types of thyroid tumors with unclear diagnostic and prognostic impact. Most variants are somatic, but they can also be germline, which are associated with PTEN hamartoma tumor syndrome (PHTS). PHTS includes Cowden syndrome, which is characterized by hamartomas, an...

ea0099p377 | Thyroid | ECE2024

Characterization of a series of 661 papillary throid microcarcinoma with excellent response to treatment

Rodrigues Elisabete , Silva Paulo , Magalhaes Joao , Pinto Mafalda , Pimenta Tiago , Sobrinho-Simoes Manuel , Soares Paula

Introduction: The management of small size (≤ 1 cm) papillary thyroid carcinoma, also known as papillary thyroid microcarcinoma (PTMC) is a debated topic as it includes tumors with a wide range of biological characteristics and behavior.Objectives: To describe prevalence, clinical and histological characteristics of PTMC with excellent response to treatment after a median follow up of 9.85±6.21 years.Methods: We did a re...

ea0099p378 | Thyroid | ECE2024

Ocular myasthenia gravis and sub clinical hyperthyroidism- a rare occurrence

Qazi Umer , shaikhali Yusuf , Kostoula Melina

Introduction: The coexistence of myasthenia gravis (MG) and autoimmune thyroid disease (AITD) is well recognised, with 5-10% of MG patients also having an AITD1-2. Among AITD, hyperthyroidism association with MG is the most common3. Conversely, MG has a relatively low incidence of around 0.2% in individuals with hyperthyroidism2, 4. This implies a potential immunological cross-reactivity between the neuromuscular junction and thyroid components...

ea0099p379 | Thyroid | ECE2024

Autoimmune endocrinopathies in patients with relapsing and remitting multiple sclerosis

Chatzi Sofia , Georgakopoulou Vasiliki , Paschou Stavroula , Boutzios Georgios

Introduction: Patients with multiple sclerosis (MS) demonstrate, in a number of studies, increased risk of acquiring another autoimmune disease compared to general population. Autoimmune thyroid diseases, type 1 diabetes, psoriasis and inflammatory bowel disease are the most common reported. The aim of our study is to determine potential factors that affect the presence of autoimmune endocrinopathies in patient with relapsing and remitting MS.Methods: We...

ea0099p380 | Thyroid | ECE2024

Interrelationships between thyroid function, autoimmunity, low-grade inflammation, lipid profile and insulin resistance in graves’ disease

Neves Celestino , Sergio Neves Joao , Miguel Pereira Luis , Sokhatska Oksana , Queiros Joana , Luis Delgado Jose

Aim: The aim of this study was to evaluate the association between thyroid function in Graves’ disease (GD) with high-sensitivity C-reactive protein (hs-CRP), lipid profile, homocysteine, folate, vitamin B12 and insulin resistance.Methods: We performed a cross-sectional of 104 patients with recently diagnosed GD. All participants were in the first cycle of treatment with methimazole. We collected demographic information, body mass indexes (BMI), lab...

ea0099p381 | Thyroid | ECE2024

Serum CD5L as potential biomarker of thyroid hormone status during pregnancy

Asaad Sabrina , Chillon Thilo , Filipowicz Dorota , Wilms Britta , Strenge Frank , Szczepanek-Parulska Ewelina , Waldemar Minich , Meyhofer Sebastian , Marquardt Jens , Mittag Jens , Oster Henrik , Ruchala Marek , Schomburg Lutz

Introduction: The thyroid hormone (TH) status is routinely assessed by thyrotropin (TSH) and thyroxine (T4). Both biomarkers are mainly regulated by thyroid hormone receptor beta, whereas many peripheral organs employ the alpha receptor. Serum CD5L is a liver-derived protein under control of both TH receptor isoforms, but the data base is small [1]. An additional biomarker of TH status is needed in particular during pregnancy, where the routine biomarkers become dynamically di...

ea0099p382 | Thyroid | ECE2024

Antithrombotic/anticoagulant drugs did not increased the risck of bleeding during thyroid fna (nor it´s whithdrawal up to one month reduced it´s risk)

Roque Catarina , Correia Claudia , Silva Sandra , Caldeira, Nurse Andreia , Valadares, Nurse Ricardo , Paula Fernandes, Nurse Ana , Barreiros, Nurse Filipa , Osorio Ana , Oliveira Sofia , Fonseca Ricardo

Introduction: Thyroid fine-needle aspiration cytology (TFNA) is a widely used diagnostic method that is generally safe. Aiming to reduce haemorrhage doctors frequently advise patients to withdrawal antithrombotic/anticoagulant (AT/AC) drugs before TFNA. There are no guidelines recommending so and the so called ‘novel anticoagulants’ have been poorly studied in this context. Some patients are likely being exposed to increased thrombotic risk unnecessarily. Evidence is...

ea0099p383 | Thyroid | ECE2024

Simultaneous presentation of thyrotoxicosis and diabetic ketoacidosis in two previously healthy men

Meriem Hani , Fedwa Boucelma , Hanane Allal , el ghebir Imane , Abderrahmane Samir Ait

Graves’ disease and type 1 DM (T1DM) both have an autoimmune aetiology. Also, Thyrotoxicosis (TT) has previously been described as a possible precipitant of diabetic ketoacidosis (DKA) in patients with T1DM. Due to the similarities in their clinical presentation, DKA can mask the diagnosis of TT and vice versa. We report two cases of the simultenous presentation of thyrotoxicosis and diabetic keto-acidosis in two previously healthy men. Case 1: A 27-year-old man with...

ea0099p384 | Thyroid | ECE2024

Echocardiographic differences between the mild form of subclinical hypothyroidism and healthy subjects

Velkoska Nakova Valentina , Krstevska Brankica , Srbinovska Kostovska Elizabeta , Georgievska Ismail Ljubica , Volkanovska Ilijevska Cvetanka , Milenkovic Tatjana

Background: Treatment of subclinical hypothyroidism (ScH) when TSH is between the upper reference value and 7mU/L, especially in patients younger than 65 years is controversial.Objectives: To compare the risk factors for atherosclerosis and echocardiographic parameters in patients with ScH1 (4, 2≤TSH≤7mU/L) to euthyroid subjects and patients with ScH2 (TSH>7mU/L).Material and Methods: Prospectively 54 consecutive pa...

ea0099p385 | Thyroid | ECE2024

hCG-TSHR cross-interaction: a rationale for in hyperemesis gravidarum?

Perri Carmela , Lazzaretti Clara , Baschieri Lara , Marchetti Lorenzo , Sperduti Samantha , Fusco Claudia , Simoni Manuela , Brigante Giulia , Casarini Livio

About 50% of women have nausea and vomiting during pregnancy. In about 35% of women who have these symptoms, nausea and vomiting are clinically significant, worsening their living conditions and consisting in a case of gender gap. The severe form, hyperemesis gravidarum, ranges from 0.3 to 1.0% of cases and is characterized by persistent vomiting, gestational thyrotoxicosis, weight loss of more than 5%, ketonuria, hypokalemia and dehydration, although the pathophysiological me...

ea0099p564 | Thyroid | ECE2024

Pathogenic variants of CHEK2 gene in thyroid cancer (TC) patients with a personal and/or familial history of other malignancies

Kapusta Dominika , Domagała Bartosz , Kapczyński Norbert , Kachnic Marek , Nogieć Anna , Trofimiuk-Muldner Malgorzata , Hubalewska-Dydejczyk Alicja

CHEK2, located on chromosome 22q, is a tumor suppressor gene. Its’ pathogenic variants are often associated with a tumor predisposition syndrome 4, with an increased risk of breast, prostate and colorectal cancers. There are some reports of an increased risk of papillary thyroid cancer (PTC) in carriers of the CHEK2 pathogenic variants. Current guidelines, however, do not recommend general screening of TC patients. The study assessed the prevalence of pa...

ea0099p565 | Thyroid | ECE2024

Molecular characterization of circulating tumor cells (CTCs) in sporadic medullary thyroid carcinoma (spMTC) patients

Simeakis George , Lagopodi Elina , Saltiki Katerina , Romei Cristina , Ciampi Raffaele , Ramone Teresa , Constantoulakis Pantelis , Alevizaki Maria , Elisei Rossella , Markoy Athina , Lianidou Evi

Objectives: Distant metastases (DM) and/or biochemical persistent disease (BPD) in MTC, adversely affect disease prognosis. Calcitonin and CEA doubling-times (DTs) are the main prognostic indicators for disease progression. Liquid biopsy based on CTCs enrichment and characterization seems to be an intriguing non-invasive tool providing information about tumor biology and molecular identity. The aim of this study was the molecular characterization of CTCs in spMTC patients with...

ea0099p566 | Thyroid | ECE2024

Modified systemic inflammation score for prediction of malignancy in indeterminate thyroid nodules- an effective tool in low-resource settings!

Manjunath Shreyamsa , Kumar Devarbhavi Praveen

Background: About 20% of thyroid-nodules have indeterminate-cytology (IDC), classified as Bethesda categories-III/ IV. They carry varying risks of malignancy (6-18%, 10-40% respectively). Ideal test to determine the risk of malignancy in IDC is unclear. Molecular-profiling has shown promise, but availability & affordability is an issue. We aim to evaluate diagnostic value of modified systemic inflammation score(mSIS) to determine malignancy in IDC.Me...

ea0099p567 | Thyroid | ECE2024

Genetic and environmental factors in autoimmune thyroid disease: exploring the associations with selenium levels and novel genetic loci in a latvian cohort

Upmale-Engela Sabine , Kalere Ieva , Pečulis Raitis , Rescenko Raimonds , Litvina Helena , Zake Tatjana , Skesters Andrejs , Gogins Deniss , Rovite Vita , Konrade Ilze

Background: The interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD) in the form of Graves’ disease (GD) and Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which in the form of selenoproteins strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine ...

ea0099p568 | Thyroid | ECE2024

Long-term outcomes in children and young adults with graves’ disease

Gewert Klara , Udumyan Ruzan , Sjolin Gabriel , Lantz Mikael , Nystrom Helena Filipsson , Khamisi Selwan , Holmberg Mats , Calissendorff Jan , Hallengren Bengt , Wallin Goran , Planck Tereza

Introduction: Graves’ disease (GD) can negatively affect the quality of life. Research on GD in childhood, accounting for 1-5% of cases, has so far predominantly focused on treatment results. There is limited knowledge about association with other diseases and long-term psychosocial effects.Aims: We aimed to compare disease burden and psychosocial outcomes between childhood/young adult GD patients and unexposed population controls.<p class="abst...

ea0099p569 | Thyroid | ECE2024

Thyroid core-needle biopsy. first experience in romania. 281 cases with only 1% non-diagnostic results

Mammadov Emin , Terzea Dana , Ciprian Stoicea Mihai

Background: There are two types of thyroid nodule biopsy: fine-needle aspiration (FNAB) and core-needle (CNB). Multiple studies mainly from Eastern Asia demonstrate safety and efficacy of CNB, however it is very rarely used in Europe.Methods: Retrospective analysis of the first 281 CNBs performed in Romania, including 8 lymph nodes and 3 thyroid bed lesions. We used the Korean Thyroid Association reporting system (KTA-CNB) for histology reports.<p cl...

ea0099p570 | Thyroid | ECE2024

Impact of the introduction of minimally invasive treatments of the thyroid (MITT) for benign thyroid nodules in an italian hospital: a cost-minimization analysis

Novizio Roberto , Cicia Martina , Papi Giampaolo

Background: Thyroid nodules prevalence is high in adult population, approaching 60% in women and older people. Most thyroid nodules are benign and asymptomatic. However, a not negligible part of them causes compressive symptoms and/or cosmetic concerns and need treatment. In the last decades, minimally invasive treatments of the thyroid (MITT) have been proposed in clinical practice as reliable cost-effective alternative to surgery in patients with symptomatic benign thyroid n...

ea0099p571 | Thyroid | ECE2024

Enhanced predictive validity of integrative models for refractory hyperthyroidism considering baseline and early therapy characteristics: a prospective cohort study

Wang Xinpan , Li Tiantian , Li Yue , Wang Qiuyi , Cai Yun , Wang Zhixiao , Shi Yun , Yang Tao , Zheng Xuqin

Background: A subset of Graves’ disease (GD) patients develops refractory hyperthyroidism, posing challenges in treatment decisions. The predictive value of baseline characteristics and early therapy indicators in identifying high risk individuals is an area worth exploration.Methods: A prospective cohort study (2018-2022) involved 597 newly diagnosed adult GD patients undergoing methimazole (MMI) treatment. Baseline characteristics and 3-month ther...

ea0099p572 | Thyroid | ECE2024

Regulatory T and B cells in autoimmune thyroiditis

Kazakova Maria , Troshina Ekaterina , Dyakov Ilya

Introduction: Hashimoto’s thyroiditis (HT) is multifactorial disease, caused by a complex interplay of genetic, hormonal, and environmental influences that provoke the development of inappropriate immune responses against thyroid on multiple levels and the initiation of a long-standing autoimmune reaction. Interaction between cellular and humoral immunity is base of HT’s pathogenesis. Our research focuses on the functional activity and the quantity of T regulatory an...

ea0099p573 | Thyroid | ECE2024

Focal thyroid incidentalomas in 18F-PSMA PET/CT – a retrospective analysis of incidence and clinical significance

Niedziela Emilia , Niedziela Łukasz , Palyga Iwona , Kopczyński Janusz , Jaskulski Jarosław , Braziewicz Janusz , Kowalska Aldona

Introduction: 18F- Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (18F-PSMA PET/CT) is currently used in the evaluation of prostate cancer. Due to increased expression of PSMA in the neovascular endothelial cells of malignant lesions other than prostate cancer, PSMA PET/CT has become of interest to researchers in the management of thyroid cancer. The goal of this study was to evaluate the incidence and clinical signifi...

ea0099p574 | Thyroid | ECE2024

Thyrotoxicosis in metastatic choreocarcinoma

Nair Vidya , Marwood Rob , Eboh Cecil

Introduction: Choriocarcinoma is a rare gynaecological cancer arising from the trophoblastic epithelium of the placenta. HCG induced thyrotoxicosis is a rare but recognised paraneoplastic phenomenon. The association of high BHCG levels and thyrotoxic state is thought to be secondary to similarities in the structure between HCG and pituitary hormones including TSH which share the same alpha unit and enables HCG to activate the TSH receptor at high levels. Kato et al in 2004 rep...

ea0099p575 | Thyroid | ECE2024

Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) with aspirate parathormone (PTH): a case report and review of the literature

Parolin Matteo , Caruso Antonino , Sartorato Paola , Fusaroli Pietro , Pasquale De Menis Ernesto

Introduction: The prevalence of primary hyperparathyroidism is increasing owing to the more the routinely measurements of serum calcium. A single benign para-thyroid adenoma is the most frequent cause of sporadic PHPT. Primary hyperparathyroidism can also be due to ectopic mediastinal parathyroid adenoma in 11-25% of patients, more frequently involving inferior parathyroid translated in anterior mediastinum. In general to detect ectopic adenoma recent guidelines recommend the ...

ea0099p576 | Thyroid | ECE2024

Radiofrequency ablation is an effective treatment for bethesda iii nodules without genetic alterations

Fugazzola Laura , Deandrea Maurilio , Borgato Stefano , Dell'Acqua Marco , Retta Francesca , Mormile Alberto , Carzaniga Chiara , Gazzano Giacomo , Pogliaghi Gabriele , Muzza Marina , Persani Luca

Radiofrequency ablation (RFA) is effective in the treatment of thyroid nodules, leading to a 50-90% reduction with respect to baseline. Current guidelines indicate the need for a benign cytology prior to RFA, though, on the other side, this procedure is also successfully used for the treatment of papillary microcarcinomas. No specific indications are available for nodules with an indeterminate cytology (Bethesda III and IV). Aim of the present study was to evaluate the efficac...

ea0099p577 | Thyroid | ECE2024

Using routine laboratory results to establish valid thyroid reference values

Erik Aas Finn , Kelp Oskar , Husoy Magnus , Medboe Thorsby Per , Westbye Alexander

Background: Indirect methods is developed to estimate reference limits from patient data, i.e. data from a mix of sick and healthy people. The indirect methods use a large number of results. A prerequisite for the methods to work satisfactorily is that the proportion of patients is not too large (typically < 20-30%).Methods: We used direct and indirect methods for estimating reference limits for TSH, FT4, FT3, total T4 and total T3. All analysis were...

ea0099p578 | Thyroid | ECE2024

12-month outcome with microwave ablation in benign thyroid nodules

Villa Kelly , Rodrigo Maite , Squarcia Mattia , A Hanzu Felicia , Orois Aida , Claro Maria , Andrea Castillo Arias Karen , Mora Mireia

Most thyroid nodules are benign and majority do not require treatment, except for those large nodules that cause symptoms (compression, hormonal dysfunction and/or esthetic problems). Microwave ablation (MWA) is an attractive therapeutic option because it is minimally invasive, relatively inexpensive, capable of providing coagulative necrosis, and has a short treatment time. In the following, we present the experience of our hospital.Objective: To evalua...

ea0099p579 | Thyroid | ECE2024

Is autoimmune thyroiditis in females with ehlers–danlos syndrome associated with lower bone density?

Emilia Babula , Aleksandra Żuk-Łapan , Iga Poprawa , Jakub Podstawka , Jan Domański , Latocha Julia , Szymańska Zuzanna , Kaluza Bernadetta , Edward Franek

Background: Collagen, whose biosynthesis is regulated by thyroid hormones, is the most abundant connective tissue protein. Ehlers–Danlos syndrome alters collagen structure, which may affect bone mineral density (BMD). The purpose of this study was to assess the effect of autoimmune thyroiditis on BMD in females with Ehlers–Danlos syndrome.Material and methods: The study involved a prospective assessment of 30 female patients, aged 20–53 ye...

ea0099p580 | Thyroid | ECE2024

Correlation between the expected risk of malignancy according to FNA and the actual percentage of malignancy found on pathological anatomy in thyroidectomies and hemithyroidectomies

Lopez Guerra Aurelio , Losada Gata Isabel , Gomez-Gordo Hernanz Monica , Collado Gonzalez Gloria , Perez Noguero Marta , Jimenez Hernando Ignacio , Farache Suberviola Blanca , Morales Jaurrieta Amaya , Gonzalez Fernandez Laura , Garcia Piorno Alberto

Introduction: The Bethesda system gives each Fine Needle Aspiration (FNA) category a risk of malignancy (B1: 5-10%, B2: 0-3%, B3: 10-30%, B4: 25-40%, B5: 50-75%, B6: 97-99%). Based on this risk, therapeutic decisions are made that influence the patient’s life. It is important to check whether the percentage of malignancy obtained in our daily clinical practice is similar to that expected according to this system.Aim: To check whether the percentage ...

ea0099p581 | Thyroid | ECE2024

Thyroid function might decrease after adjuvant chemotherapy in postmenopausal women with early breast cancer

Marina Djordje , Buch-Larsen Kristian , Gillberg Linn , Andersen Mads , Andersson Michael , Krogh Rasmussen AEse , Schwarz Peter

Objective: Adjuvant chemotherapy is often indicated in patients diagnosed with early breast cancer. Weight gain is one of the observed side effects of both chemotherapy and other cancer treatments, however, the mechanism is not well-described. In this study, we aimed to assess thyroid function before- and after the course of chemotherapy for early breast cancer.Methods: This study is a 5-year prospective cohort study of patients diagnosed with early brea...

ea0099p582 | Thyroid | ECE2024

Epidemiology of primary hypothyroidism in the republic of moldova

Vudu Stela

Disorders of the thyroid gland in the Republic of Moldova rank second among endocrine diseases (after diabetes mellitus), hypothyroidism being one of the most widespread diseases. In communities, the prevalence of overt hypothyroidism is from 0.1 to 2 percent, and that of subclinical hypothyroidism is up to 10 percent of adults (increasing even more in women, and with advanced age). Regarding the prevalence of hypothyroidism in the Republic of Moldova, it is necessary to menti...