Blood phospholipid profile in patients with type 1 diabetes mellitus combined with ischemic heart disease

Gulnora Artykbaeva; Talat Saatov

doi:10.1530/endoabs.99.EP166

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Endocrine Abstracts (2024) 99 EP166 | DOI: 10.1530/endoabs.99.EP166

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Blood phospholipid profile in patients with type 1 diabetes mellitus combined with ischemic heart disease

Gulnora Artykbaeva & Talat Saatov

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Institute of Biophysics and Biochemistry, Mirzo Ulugbek National University of Uzbekistan, lab of metabolomics, Tashkent, Uzbekistan

For quite a long period of time, diabetes mellitus (DM) has been considered as the carbohydrate metabolism disorder; to maintain blood glucose normal was believed to be the only mission of insulin. By now, findings from many studies have proved that DM is accompanied by the complex disorder of metabolism not only for carbohydrates, but also for lipids and proteins. Atherosclerotic injury of large vessels and ketoacidosis are known to be the main DM complications. The work was initiated to study disorders of phospholipid metabolism in patients with type 1 DM and its combination with ischemic heart disease (IHD).

Materials and methods: We examined 34 patients with type 1 DM. The group of DM+IHD included 25 patients. The control one consisted of 11 healthy persons. The blood phospholipids were fractionated by thin-layer chromatography.