Plasma SHBG levels as an early predictor of response to bariatric surgery

Pablo Gabriel-Medina; Roser Ferrer; Francisco Rodriguez-Frias; Marta Comas; Ramon Vilallonga; Andreea Ciudin; David Selva

doi:10.1530/endoabs.99.EP277

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Endocrine Abstracts (2024) 99 EP277 | DOI: 10.1530/endoabs.99.EP277

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Plasma SHBG levels as an early predictor of response to bariatric surgery

Pablo Gabriel-Medina ¹ , Roser Ferrer ^1,1,2,2 , Francisco Rodriguez-Frias ¹ , Marta Comas ³ , Ramon Vilallonga ⁴ , Andreea Ciudin ³ & David Selva ⁵

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¹Vall d’Hebron University Hospital, Clinical Biochemistry Department, Barcelona, Spain; ², Clinical Biochemistry Department, Barcelona; ³, Vall d’Hebron University Hospital, Endocrinology and Nutrition Department, Barcelona, Spain; ⁴Center of Excellence for the EAC-BC and Vall d’Hebron University Hospital, Endocrine, Metabolic and Bariatric Unit, Barcelona, Spain; ⁵Vall d’Hebron Research Institute, Diabetes and Metabolism, Barcelona, Spain

Background: Obesity is a growing global health problem and currently bariatric surgery (BS) is the best solution in terms of sustained total weight loss (TWL). However, a significant number of patients present weight regain (WR) in time. There is a lack of biomarkers predicting the response to BS and WR during the follow-up. Plasma SHBG levels, which are low in obesity, increase one month after BS but there is no data of plasma SHBG levels at long term. We performed the present study aimed at exploring the SHBG role in predicting TWL and WR after BS.

Methods: Prospective study including 62 patients with obesity undergoing BS. Anthropometric and biochemical variables, including SHBG were analyzed at baseline, 1, 6, 12, and 24 months; TWL ≥25% was considered as good BS response.

Results: Weight loss nadir was achieved at 12 months post-BS where maximum SHBG increase was reached. ≥25% TWL patients presented significantly higher SHBG increases at 1st and 6^th month follow-up respect to baseline (100% and 150% respectively, P=0.025), than <25% TWL patients (40% and 50% respectively, P=0.03). Also, these presented 6.6% WR after 24 months. The 1st month SHBG increase predicted BS response at 24 months (OR=2.71; 95%CI=[1.11-6.60]; P=0.028) and TWL in the 12th month (r=0.330, P=0.012) and the WR in the 24th month after BS (r=-0.301, P=0.028).

Conclusion: Our results showed for the first time that increase in plasma SHBG levels within the first month after BS is a good predictor of TWL and WR response after two years.