The usefulness of 18F-choline PET/CT in patients with negative findings on 99mTc-sestamibi SPECT/CT in Locating Hyperfunctioning Parathyroid Glands in Primary Hyperparathyroidism

Ante Mandic; Ivana Kraljevic; Polovina Tanja Skoric; Tomsic Karin Zibar; Tina Dusek; Annemarie Balasko; Mirsala Solak; Darko Kastelan

doi:10.1530/endoabs.99.EP29

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Endocrine Abstracts (2024) 99 EP29 | DOI: 10.1530/endoabs.99.EP29

ECE2024 Eposter Presentations Calcium and Bone (102 abstracts)

The usefulness of 18F-choline PET/CT in patients with negative findings on 99mTc-sestamibi SPECT/CT in Locating Hyperfunctioning Parathyroid Glands in Primary Hyperparathyroidism

Ante Mandic ¹ , Ivana Kraljevic ^2,3 , Tanja Skoric Polovina ² , Karin Zibar Tomsic ² , Tina Dusek ^2,3 , Annemarie Balasko ² , Mirsala Solak ² & Darko Kastelan ^2,3

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¹University Clinical Hospital Mostar, Department of Endocrinology, Mostar, Bosnia and Herzegovina; ²University Hospital Centre Zagreb, Zagreb, Croatia; ³School of Medicine, University of Zagreb, Zagreb, Croatia

Objective: This study aimed to investigate the diagnostic performance of ¹⁸F-choline PET/CT in patients with negative or inconclusive results of ^99mTc-sestamibi SPECT/CT in locating hyperfunctioning parathyroid tissue in primary hyperparathyroidism patients.

Methods: We conducted a retrospective study involving patients who were operated on due to primary hyperparathyroidism from April 2019 to March 2022. The analysis focused on patients undergoing ¹⁸F-choline PET/CT scan due to previously negative or inconclusive findings on ^99mTc-sestamibi SPECT/CT in order to localize a hyperfunctioning parathyroid gland(s). Pathohistological reports were used as a reference standard for the assessment of imaging results.

Results: The study included 29 patients (23 (79.3%) females), with a mean age of 56.3 years (range 25–74). Pathohistological analysis revealed 36 glands. The detection rate of ¹⁸F-choline PET/CT in per lesion analysis was 88.9% (95% CI 70.8–97.7).

Conclusion: The results of our study showed the significant usefulness of ¹⁸F-choline PET/CT in patients with negative or inconclusive results of ^99mTc-sestamibi SPECT/CT in accurately locating hyperfunctioning parathyroid glands in primary hyperparathyroidism patients.