Endocrine Abstracts

Introduction: Evidence suggests that, for the same mean glucose level, protein glycation may be different and that this may have an impact on the occurrence of complications. We currently have GMI that estimates mean glucose measured with the FreeStyle Libre 2 and HbA1c determined in the laboratory.

Objectives: To analyse the proportion of “rapid glycaemic” patients in our clinical setting (HbA1c-GMI>0.5) and to assess the prevalence of microvascular complications (retinopathy, nephropathy, and neuropathy) in these patients and compare with the rest of the sample.

Methods: Cross-sectional descriptive observational study in people with type 1 diabetes mellitus followed up in the Diabetes Unit of the Axarquia Hospital carrying the FreeStyle Libre 2 system. Variables collected: age, sex, presence of microvascular complications, GMI and HbA1c.

Results: 291 patients were included, mean age 42.9 ±14.8 years, 40% female, time of evolution 20.4 ± 13 years. Prevalence of microvascular complications 36.3% (9.8% nephropathy, 32.4% retinopathy and 12.9% neuropathy). Mean IGM 7.4 ±0.941% and mean HbA1c 7.70±1.17%. HbA1c-GMI difference: 0.170±0.708. Proportion of rapid glycators: 26.1%. A significantly higher prevalence of microvascular complications was found (47.4 vs 34 <% with P 0.038), with statistically significant difference in retinopathy (44 vs 29.3% with P 0.020), neuropathy (21.1 vs 10.2% with P 0.016). The difference in nephropathy was not statistically significant (14.5 vs 8.8% with P 0.165).

Conclusions: The proportion of rapid glycators in our sample is high (26.1%). Rapid glycators in our sample have a higher prevalence of microvascular complications (retinopathy and diabetic neuropathy).