Endocrine Abstracts

Introduction: The association between acromegaly and neoplasia is rare but described, particularly colorectal and thyroid cancers, especially since the disease is not controlled.

Observation: We report the case of a 44-year-old patient, hypertensive, diabetic, followed for acromegaly clinically retained in the face of dysmorphic syndrome, an IGF1 at 3.5 times normal on a pituitary macroadenoma of 9.9x13x9.3. The assessment of the impact of this acromegaly was without abnormalities. For the neoplastic risk, a colonoscopy returned without abnormalities and a cervical ultrasound revealed a right mid-lobar nodular formation of 10x9 mm classified Eu-Tirads 5, with a fine puncture in favor of a papillary carcinoma of the thyroid. He underwent a total thyroidectomy and the anatomo-pathological examination confirmed the diagnosis: papillary carcinoma of the thyroid of 9 mm right infiltrating the thyroid capsule without crossing it with vascular emboli and perineural sheathing classified pT1a NxMx is classified at high risk of recurrence according to ATA2015 supplemented by 100mci iratherapy.

Discussion: The occurrence of differentiated thyroid cancers is reported in acromegaly. It is related to active secretion of GH-IGF1. Acromegaly is associated in 25% of cases with papillary thyroid carcinoma independently of the BRAF mutation according to one study. In our patient, the number of years of progression of his disease as well as the failure to obtain biological control would be incriminated.