Lymphocytic pituitary revealed by diabetes insipidus

Hana Charfi; Fatma Mnif; Salah Dhoha Ben; Mouna Elleuch; Mouna Mnif; Nadia Charfi; Kacem Akid Faten Haj; Mohamed Abid; Majdoub Nabila Rekik

doi:10.1530/endoabs.99.EP692

EP692

Prev Next

Section Contents Cite

Endocrine Abstracts (2024) 99 EP692 | DOI: 10.1530/endoabs.99.EP692

ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)

Lymphocytic pituitary revealed by diabetes insipidus

Hana Charfi ¹ , Fatma Mnif ¹ , Dhoha Ben Salah ¹ , Mouna Elleuch ¹ , Mouna Mnif ¹ , Nadia Charfi ¹ , Faten Haj Kacem Akid ¹ , Mohamed Abid ¹ & Nabila Rekik Majdoub ¹

Err

Author affiliations

¹Hedi Chaker Hospital, Sfax, Tunisia

Introduction: Lymphocytic hypophysitis (LH) is most likely of autoimmune origin, as it is associated with other autoimmune diseases in 20 to 25% of cases, with the most common being lymphocytic thyroiditis. It is common in young women in late pregnancy or postpartum. Diabetes insipidus (DI) occurs in approximately 35% of patients with LH. To link DI to LH, we investigated the clinical, biological, and radiological characteristics of patients with DI.

Patients and Methods: A retrospective and monocentric descriptive study conducted in the Endocrinology Department of Hedi Chaker University Hospital in Sfax over a 20-year period (2000-2020). We identified 44 cases of DI, examined the records, and selected 6 cases of DI secondary to LH.

Results: All our patients were female with an average age of 36.16 years [22-47]. The discovery circumstance was secondary polyuria and polydipsia (SPUPD) in all patients. Family autoimmunity (AI) was reported in 33.33% of cases. Personal AI was described in 50% of cases, with Hashimoto’s thyroiditis in two patients. Water deprivation test was performed in all patients, except one who underwent an initial pituitary MRI, leading to the diagnosis of partial central diabetes insipidus (DIC) in 20% of cases and complete DIC in the remaining cases. Pituitary hypertrophy was described in 33.33% of patients, initially suggesting a diagnosis of granulomatosis, eliminated by the negativity of specific investigations.

Conclusion: Recognition of LH in the context of DI is crucial for prompt diagnosis and appropriate management, particularly given its potential autoimmune origin and frequent association with other autoimmune conditions. This insight can guide clinicians in refining diagnostic approaches and optimizing patient care for individuals presenting with DI.