Interrelation of TNF-[alpha] concentrations with the onset and progression of diabetic complications

Elvira Ibragimova; Talat Saatov; Timur Alimov; Sanobar Irgasheva; Tokhir Ishankhodjaev; Gulnora Artykbaeva; Nigora Maksutova; Abdunabi Tashtemirov; Zulaykho Shamansurova

doi:10.1530/endoabs.99.EP792

EP792

Prev Next

Section Contents Cite

Endocrine Abstracts (2024) 99 EP792 | DOI: 10.1530/endoabs.99.EP792

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Interrelation of TNF-α concentrations with the onset and progression of diabetic complications

Elvira Ibragimova ¹ , Talat Saatov ¹ , Timur Alimov ^1,2 , Sanobar Irgasheva ^1,3 , Tokhir Ishankhodjaev ¹ , Gulnora Artykbaeva ¹ , Nigora Maksutova ⁴ , Abdunabi Tashtemirov ¹ & Zulaykho Shamansurova ^1,5

Views

Author affiliations

¹Institute of Biophysics and Biochemistry, Mirzo Ulugbek National University of Uzbekistan, Tashkent, Uzbekistan; ²Republican Specialized Scientific Practical Medical Center of Hematology and Blood Transfusion, Uzbekistan Public Healthcare Ministry, Tashkent, Uzbekistan; ³Alfraganus University, Tashkent, Uzbekistan; ⁴Ya. Kh. Turakulov Center for Scientific and Clinical Study of Endocrinology, Uzbekistan Public Healthcare Ministry, Tashkent, Uzbekistan; ⁵Central Asian University, Tashkent, Uzbekistan

As a cytokine, TNF-α plays a role of key anti-inflammatory mediator involved in the onset and progression of insulin resistance and type 2 diabetes mellitus. TNF-α is known to inhibit insulin-stimulated of auto-phosphorylation of insulin receptors by tyrosine kinase; as the result, insulin sensitivity decreases in its turn resulting in insulin resistance and glucose transport damage. TNF-α is a trigger in the onset of obesity, diabetes mellitus and its complications. Studies on concentrations of TNF-α in peripheral blood are of high importance in assessment of extent in type 2 diabetes mellitus progression.

Materials and methods: 68 patients with type 2 diabetes mellitus, 50 persons with diabetic neuropathy of various degrees and 18 persons without any 2DM complications among them, were examined. Non-diabetics were included into the control group. ELISA was used to determine TNF-α concentrations in the blood serum of the examinees.

Results: Determination of TNF-α concentrations in blood serum of the examinees demonstrated their significant increase as compared to those in the non-diabetics (3.05±0.44 vs 1.1±0.05 pg/ml). In patients with moderate diabetic neuropathy, the serum concentrations of TNF-α turned out significantly lower than those in patients with severe disease (3.62±0.89 vs 7.13±1.14 pg/ml). Thus, paralleling disorders in carbohydrate and lipid metabolism in 2DM, concentrations of TNF-α in blood serum of the patients were found to be in direct dependence with the disease severity.