Mean platelets volume and diabetic retinopathy in patients with diabetes mellitus

Hadhemi Belhassen; Mizouri Ramla; Siwar Saoudi; Faten Mahjoub; Chaima Sdiri; Amor Nadia Ben; Olfa Berriche; Jamoussi Henda

doi:10.1530/endoabs.99.EP805

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Endocrine Abstracts (2024) 99 EP805 | DOI: 10.1530/endoabs.99.EP805

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Mean platelets volume and diabetic retinopathy in patients with diabetes mellitus

Hadhemi Belhassen ^1,1 , Mizouri Ramla , Siwar Saoudi , Faten Mahjoub , Chaima Sdiri , Nadia Ben Amor , Olfa Berriche & Jamoussi Henda

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National Institute of Nutrition, A, Tunis, Tunisia

Introduction: Mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Higher levels of MPV are encountered in conditions with increased production in response to increased destruction of platelets. Some studies suggest an association between impaired platelet function and vascular complications in patients with diabetes mellitus. The aim of our study is to prove this association.

Methods: Descriptive cross-sectional study conducted over 4 months in ward A of The National Institute of Nutrition Tunis which included patients with diabetes mellitus.

Results: Sixty patients were included of whom 41 were women and 19 men. The characteristics of the patients were: age: 50±16.46 years, 44 patients with type 2 diabetes mellitus and 16 with type 1 diabetes mellitus, 20% were treated with oral medication, 35% with human insulin and 13% with insulin analogs, HbA1C: 10.2%±1.8. Mean values for MPV in patients with diabetic retinopathy, without diabetic retinopathy were 10.97±0.74 fL and 11.01±0.9fL, respectively. There was no statistically significant correlation between MPV and the development of diabetic retinopathy (P=0.751).

Conclusion: Although MPV can be a predictor of the platelets’ high activity in diabetes mellitus, other risk factors of micro or macroangiopathy must be taken into consideration while monitoring the disease progression.