ECE2024 Poster Presentations Pituitary and Neuroendocrinology (120 abstracts)
Implications of somatotroph axis in the behaviour of silent corticotroph tumours
Cristina Guillen 1,2,3 , Johana Sottile 1 , Elena García-Garrigós 1,2,2,4 , Maria Eugenia Torregrosa 1,2,5 , Maria Niveiro 1,2,6 , Javier Abarca 1,2,7 , Luis Valor 1 & Antonio Pico 1,2,3,8,9
1Instituto de Investigación Sanitaria y Biomédica de Alicante (Isabial), Endocrinology & Nutrition, Alicante, Spain; 2Hospital General Universitario Dr. Balmis, Radiology; 3, Endocrinology & Nutrition; 4, Radiology; 5, Clinical Analysis-Hormones; 6, Pathology; 7, Neurosurgery; 8University Miguel Hernandez, Clinical Medicine, Alicante; 9Ciberer, Neuroendocrinology
Silent corticotroph tumors (SCT) represent a distinct subtype of pituitary tumors (PT) known for their potential aggressiveness, surpassing other silent PTs like gonadotroph tumors (SGT). Despite their aggressive clinical behavior, the mechanisms underlying their aggressiveness remain unclear. Recent studies in various cancers, such as breast cancer, have implicated the IGF1 axis in the presence of metastases. This study aims to investigate some components of the somatotroph axis in a cohort of 31 SCTs and a control group of 67 SGTs, all monitored in a PTOCE since 2012. Demographic, biochemical, and radiological variables were analyzed, alongside the expression (quantitative PCR) of GH, GHRH, and somatostatin subtype receptors (sst1,2,3,5). Results showed that SCT patients were predominantly women and younger compared to SGT patients. While tumor size and invasion percentages showed no significant differences between groups, SCTs exhibited a significantly higher Signal Intensity Ratio (SIR) and increased proliferation (Ki67 qPCR), along with a higher recurrence rate than SGTs. Cortisol levels were comparable, but SCTs displayed significantly elevated levels of ACTH and, notably, IGF1 compared to SGTs. SCTs had significantly higher expression of sst2, and lower expression of sst3, with no significant differences in the expression of GH, GHRH, and sst1,5 between the two groups. In conclusion. Elevated levels of ACTH and IGF1 in SCTs underscore the intricate interplay between the somatotroph and corticotroph axes. These findings suggest a potential crosstalk mechanism that contributes to the unique characteristics of SCTs, influencing their aggressiveness and clinical course and offering a more tailored and effective therapeutic approach
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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