Characterization and stratification of familial hyperlipidemia using the dutch clinical criteria in a south american population

Dulcey Sarmiento Luis Andres; Hernandez Navas Jorge Andres; Ayala Jaime Gomez; Juan Theran; Navas Valentina Hernandez; Castellanos Valentina Ochoa; Pinzon Harold Torres

doi:10.1530/endoabs.109.EP24

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Endocrine Abstracts (2025) 109 EP24 | DOI: 10.1530/endoabs.109.EP24

SFEBES2025 ePoster Presentations Metabolism, Obesity and Diabetes (14 abstracts)

Characterization and stratification of familial hyperlipidemia using the dutch clinical criteria in a south american population

Luis Andrés Dulcey Sarmiento ¹ , Jorge Andrés Hernández Navas ² , Jaime Gómez Ayala ³ , Juan Theran ² , Valentina Hernández Navas ² , Valentina Ochoa Castellanos ² & Harold Torres Pinzon ²

Author affiliations

¹University of Andes, Mérida, Venezuela; ²University of Santander, Bucaramanga, Colombia; ³Autonomous University of Bucaramanga, Bucaramanga, Colombia

Introduction: Familial hyperlipidemia (FH) refers to inherited genetic disorders that lead to elevated serum cholesterol levels, primarily low-density lipoprotein (LDL) cholesterol. Early detection is essential to prevent cardiovascular disease (CVD). The prevalence of FH in Colombia is unknown, and the Dutch Lipid Clinic Network (DLCN) criteria are widely used for diagnosis.

Objective: This study aimed to identify FH cases in a population from northwestern Colombia using the DLCN criteria and describe associated clinical characteristics.

Materials and Methods: A retrospective study included patients aged 18 to 95 years with available lipid profiles and cardiometabolic data. The DLCN criteria were applied to identify FH. Patients with incomplete data or secondary causes of hyperlipidemia (e.g., hypothyroidism or nephrotic syndrome) were excluded.

Results: Of 25 patients meeting the DLCN criteria, 56% were male, with the highest prevalence between the fourth and fifth decades. Most (80%) were classified as having very high cardiovascular risk, and 70% had a history of coronary or cerebrovascular disease, aligning with existing literature.

Discussion: These findings reveal a significant cardiovascular burden in individuals with FH, emphasizing the need for early detection, particularly in middle-aged men. The strong association between FH and CVD highlights the importance of targeted screening and timely intervention.

Conclusion: Greater awareness of FH is needed to promote early diagnosis, especially in individuals with a family history of hyperlipidemia or premature CVD. Expanding screening efforts in primary care is essential to improve patient outcomes and prevent cardiovascular complications.