SFEBES2025 Poster Oral Presentations Reproductive Endocrinology (4 abstracts)
Prevalence and factors associated with increased obstructive sleep apnoea risk in women with polycystic ovary syndrome: results from the DAISy-PCOS study
Eka Melson 1,2 , Tara McDonnell 3 , Meryem Ertugrul 1,2 , Thais P. Rocha 4 , Leanne Cussen 3 , Cara Go 5 , Fannie Lajeunesse-Trempe 6 , Punith Kempegowda 4,7 , Merah Al-Busaidy 3 , Thozhukat Sathyapalan 8 , Jyotsna Pundir 9 , Richard Anderson 10 , Barbara McGowan 11 , D. Aled Rees 12 , Georgios K. Dimitriadis 13 , Harpal S. Randeva 14 , Channa N. Jayasena 2,5 , Alice J. Sitch 4 , Abd A. Tahrani 4 , Michael W. O’Reilly 3 , Wiebke Arlt 1,2 & for the DAISy-PCOS Investigators 2
1MRC Laboratory of Medical Sciences, London, United Kingdom; 2Imperial College London, London, United Kingdom; 3Royal College of Surgeons in Ireland, Dublin, United Kingdom; 4University of Birmingham, Birmingham, United Kingdom; 5Imperial College Healthcare NHS Trust, London, United Kingdom; 6King’s College Hospital NHS Foundation Trust, London, United Kingdom; 7University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 8Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; 9Barts Health NHS Trust, London, United Kingdom; 10University of Edinburgh, Edinburgh, United Kingdom; 11Guy’s nd St Thomas’ NHS Foundation Trust, London, United Kingdom; 12Cardiff University, Cardiff, United Kingdom; 13King’s College London, London, United Kingdom; 14University of Warwick, Coventry, United Kingdom
Introduction: Population-based studies have suggested that women with polycystic ovary syndrome (PCOS) are at increased risk of obstructive sleep apnoea (OSA). We report the prevalence of high risk of OSA in a prospectively recruited cohort of women with PCOS and identified factors associated with increased OSA risk.
Methods: Women with PCOS diagnosed according to the Rotterdam criteria were prospectively recruited in a multi-centre study in 10 centres in the UK & Ireland. The Berlin and Epworth questionnaires were completed to screen participants for risk of OSA, The Berlin questionnaire stratifies the response into high-risk and low-risk categories. The Epworth utilises a cut-off of >7 to classify high-risk category. Logistic regression models were used to identify factors that are associated with increased risks of sleep disturbances in women with PCOS.
Results: A total of 726 women with PCOS were included in our analysis [Age 30 (26-34), BMI (31.1 (25.1-38.4)]. Prevalence of increased risk of OSA were 47.3% (n = 325/687) and 48.9% (n = 355/726) with Berlin and Epworth questionnaires, respectively. Independent of BMI, hyperandrogenism [aOR: 1.97 (1.0-3.8)], and alopecia [aOR: 1.7 (1.1-2.6)] were associated with increased odds of abnormal Berlin score. With Epworth score, hyperandrogenism [aOR: 1.8 (1.0-3.0)] and having irregular periods [aOR: 1.6 (1.0-2.7)] were associated with an abnormal score, also after adjustment for BMI.
Conclusion: Independent of BMI, women with PCOS score highly on Epworth and Berlin scores, indicating increased risk of OSA. These results highlight the importance of screening for OSA in women with PCOS, regardless of BMI. Hyperandrogenism increased the odds of OSA. Thus, the role of androgens in the pathogenesis of OSA requires further study.
Volume 109
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more