Endocrine Abstracts

Introduction: Rheumatoid arthritis (RA) is a chronic immunoinflammatory disease that significantly impacts men in South America. Hypogonadism may be more prevalent in patients with RA, and testosterone deficiency could worsen disease severity. Understanding the relationship between testosterone levels and RA activity is crucial for improving patient management.

Objective: This study aims to evaluate the incidence of hypogonadism in men with rheumatoid arthritis and analyze its correlation with disease activity and concomitant illnesses.

Materials and Methods: A continuous study was conducted at a South American hospital, involving 50 men with RA receiving inpatient treatment. Total testosterone levels were measured, categorizing patients into subgroups with normal (>12 nmol/l) and reduced levels. Intergroup comparisons were made on clinical indicators used to assess RA stage and activity, alongside demographic characteristics. A correlation analysis was performed between total testosterone levels and clinical and laboratory parameters.

Results: The frequency of testosterone deficiency in the study group was 40%. Significant correlations were observed between total testosterone levels and body mass index (BMI) (r=-0.32), blood uric acid (r=-0.23), and C-reactive protein (r=-0.15). Patients with hypogonadism had a higher BMI (32.1±6.8 vs. 25.2±3.0 kg/m²; P < 0.001) and poorer disease control (DAS28 >5.1 in 36% vs. 4%; P = 0.003).

Discussion: The findings suggest that testosterone levels and hypogonadism are associated with RA stage and activity. Testosterone deficiency correlates with increased body weight and obesity, indicating the need for a multidisciplinary approach in RA management.

Conclusion: Assessing testosterone levels in men with RA is vital for understanding disease progression, as deficiency is linked to a more active disease course and higher obesity risk. A comprehensive approach considering these variables is essential for improved patient care.