Endocrine Abstracts

Introduction: The prevalence of T2DM exceeds 9% of the adult population, while cardiovascular disease accounts for approximately 52% of all deaths, highlighting the urgent need for tailored perioperative strategies for these high-risk patients. Although T2DM patients are known to face greater risks of adverse outcomes after cardiovascular surgeries, more research data needs to improve local and global diabetes management. In our study we analysed postoperative outcomes in patients with T2DM undergoing coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI).

Materials and methods: Data of 200 patients (100 with T2DM and 100 without) who underwent CABG and PCI in American Hospital in Tashkent, Uzbekistan between 2018 and 2023 were gathered and analysed and compared among those with and without T2DM also according to type of surgery. We mostly pointed in patients age, gender, pre and postoperative surgery complications, heart rate, SAD, DAD, glycemia and HbA1c level, inflammatory markers such as CRP.

Results: Among the 100 patients undergoing CABG and 100 undergoing PCI, T2DM patients showed significantly higher fasting (1.4x) and postprandial (1.6x) glycemia levels, HbA1c (1.4x), and CRP (1.54x) compared to non-diabetics (all P < 0.05). HR, SAD, and DAD were also elevated in the T2DM group. Postoperative outcomes and mortality rates were similar across CABG and PCI groups; however, T2DM patients were 1.7 times more likely to experience complications (odds ratio = 1.7, P < 0.05). Elevated CRP and preoperative HbA1c correlated with poorer postoperative indicators, underscoring the need for targeted perioperative management in diabetic patients.

Conclusions: Postoperative outcome and mortality rate were comparable in CABG and PCI group and showed significant differences between with and without T2DM and have 1.7 times higher complications. Pre and postoperative level of CRP, HbA1c were found indicator of poor outcome in those patients.