Metabolic fatty liver disease present high risk in the development of diabetes complications

Zulaykho Shamansurova; Mokhira Aykhodjaeva; Nigora Maksutova; Saidolim Makhmudov; Shamsiya Salomova; Tahmina Kasimova

doi:10.1530/endoabs.109.P157

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Endocrine Abstracts (2025) 109 P157 | DOI: 10.1530/endoabs.109.P157

SFEBES2025 Poster Presentations Metabolism, Obesity and Diabetes (68 abstracts)

Metabolic fatty liver disease present high risk in the development of diabetes complications

Zulaykho Shamansurova ^1,2 , Mokhira Aykhodjaeva ³ , Nigora Maksutova ³ , Saidolim Makhmudov ⁴ , Shamsiya Salomova ¹ & Tahmina Kasimova ⁵

Author affiliations

¹Central Asian University School of Medicine, Tashkent, Uzbekistan; ²Institute of Biophysics and Biochemistry at the NUUz, Tashkent, Uzbekistan; ³Republican Specialised Scientific Practical Medical Centre of Endocrinology, Tashkent, Uzbekistan; ⁴Toronto Metropolian University, Toronto, Canada; ⁵Sity Central Outpatient Clinic, Samarkand, Uzbekistan

Introduction: Liver have a crucial role in the body metabolism, especially in maintaining of carbohydrates level. Type 2 Diabetes Mellitus (T2DM) frequently accompanied Metabolic Fatty Liver Diseases (MAFLD) which has impact on the development of the diabetes complications. We studied relationship between diabetes microvascular complications according to presence of MAFLD.

Material and methods: 134 patients with T2DM admitted to Hospital of Republican Specialised Scientific Practical Medical Centre in Uzbekistan were observed and body weight, BMI, total blood count, fasting and postprandial glycemia, HbA1c, ALT, AST, bilirubin, blood lipids level were measured, liver ultrasound were performed. Data were compared according to presence and absence of MAFLD.

Results: MAFLD were detected in 52% of patients with T2DM. MAFLD have relationship with body weight, BMI, fasting glycemia, HbA1c, blood triglycerides, LDLP level. Moreover, diabetic microvascular complications such as retinopathy, nephropathy were presented in higher degrees in MAFLD group, DR3 seen in 34% vs 13% and CKD with uremia were detected in 26% vs 6% and suggested about role of the MAFLD in the development and progression of chronic diabetes complications. Calculated Fib4 score were significantly higher in MAFLD group. Interestingly, among patients on insulin therapy daily dosage of insulin, as well as short acting and long acting insulins were calculated and compared, where insulin dosage were significantly higher in MAFLD group and suggested about iits impact on glycemic control and microvascular complications.

Conclusion: MAFLD involved into pathogenesis of microvascular complications of T2DM by affecting glycemia, HbA1c, blood lipids level, where early detection and management is crusial for future management.