Endocrine Abstracts

Greater confidence in hormone replacement therapy (HRT) in clinical practice means that many women with complex comorbidities are now being offered HRT for menopause symptoms. Modern HRT formulations may be safer than older regimens, and accumulating evidence allows better risk stratification. However, there is a lack of outcome data for under-represented groups with complex health issues, particularly concerning cardiometabolic and gynaecological risks, oestrogen-related cancers, and testosterone use. The clinical outcomes associated with HRT regimens outside regulator-approved dosing are also unknown. Furthermore, there is a dearth of data to guide management for HRT-unsuitable women. The International Menopause Society has endorsed the case for real-world data collection in their 2024 White Paper, recognising that large-scale randomised trials using modern, novel or unconventional menopause treatments are unlikely to receive the necessary funding. The Society for Endocrinology (SfE) has also recognised the unmet need in menopause management and outcome data and the novel research opportunity to utilise innovative, secure online, real-world data collection platforms. In response, the SfE has founded the first UK women’s health real-world data registry, aiming to capture critical outcomes across essential areas of women’s health. The data collection process utilises an online platform accessed via site-specific QR codes. Following patient consent, relevant data from primary care records will be obtained through automation, with options for additional input from secondary care. The SfE will host this registry with unrestricted educational grant funding support. A steering group of leaders from endocrinology, allied specialities, affiliated charities, and patient groups underpin the registry’s operational detail. The steering group chairs will share future developments and encourage SfE members to engage with this pivotal registry through research questions and data access requests. The SfE women’s health registry is an ambitious long-term initiative aiming to support SfE members to help shape future women’s health-related research and practice.