ECEESPE2025 ePoster Presentations Bone and Mineral Metabolism (142 abstracts)
Severe hypocalcemia and psoriasis: an intriging link
Mouna Elleuch 1 , Oumeyma Trimeche 1 , Khadija Sallemi 2 , Rihab Khochtali 1 , Khouloud Boujelben 1 , Nadia Charfi 1 , Faten Haj Kacem Akid 1 , Mouna Mnif 1 , Fatma Mnif 1 , Abderrahmen Masmoudi 2 , Mohamed Abid 1 , Dhoha Ben Salah 1 & Nabila Rekik Majdoub 1
1Hedi Chaker University Hospital, Endocrinology, Sfax, Tunisia; 2Hedi Chaker Hospital, Dermatology, Sfax, Tunisia
JOINT294
Introduction: Down syndrome is a genetic disorder resulting from the presence of an extra copy of chromosome 21. The spectrum of this disorder is very broad, including endocrine and dermatological manifestations. Through this observation, we discuss an extremely rare cause of psoriasis: hypocalcemia. We demonstrate the improvement of skin lesions under prompt calcium treatment.
Observation: This is an 18-year-old patient who was hospitalized in the endocrinology department for the management of severe hypocalcemia at 0.9 mmol/l. The diagnosis of Down syndrome was made at birth due to typical dysmorphia. He has a history of seizures that have occurred for a year and have not been investigated. One month before his hospitalization, the appearance of well-defined, generalized erythemato-squamous plaques was noted, particularly on the scalp and extensor surfaces of the limbs, consistent with psoriasis. The patient was treated with topical corticosteroids without improvement, hence their discontinuation. An assessment revealed severe hypocalcemia at 0.9 mmol/l. The etiological investigation concluded to a vitamin D deficiency of less than 8 ng/ml and hypomagnesemia at 0.6 mmol/l. Vitamin and calcium supplementation, as well as magnesium, was initiated, leading to normalization of the phosphorocalcic balance and a spectacular improvement of the psoriatic lesions.
Discussion: Vitamin D deficiency is a known risk factor for psoriasis. Elsewhere, the association between hypocalcemia and psoriasis is not coincidental. Indeed, hypocalcemia can impair cell adhesion, thus favoring the onset of psoriasis. Moreover, psoriasis can cause extensive skin inflammation, resulting in extravasation of albumin and albumin-bound calcium into the interstitial space.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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