ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Acute pancreatitis in type 1 diabetic patients: etiological and evolutionary profile
Dhoha Ben Salah 1 , Nada Hassairi 1 , Kouloud Boujelben 1 , Oumaima Dimassi 1 , Faten Haj Kacem Akid 1 , Nadia Charfi 1 , Mouna Mnif 1 , Mohamed Abid 1 , Mouna Elleuch 1 & Nabila Rekik Majdoub 1
1Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT3670
Objective: This study aimed to describe the etiological and evolutionary profile of acute pancreatitis (AP) in type 1 diabetic (T1D) patients.
Patients and Methods: A retrospective descriptive study including 10 T1D patients who experienced at least one episode of AP during follow-up.
Results: The average age at T1D diagnosis was 19.7±9.3 years, with a female predominance (60%). T1D was frequently first diagnosed through classic cardinal symptoms (50%) or spontaneous DKA (20%). In 10% of cases, T1D was diagnosed during an AP episode. AP occurred at an average age of 26.9±14.9 years. AP was classified as stage E in 57.1% of cases, while stages A, B, or C were less frequently reported (14.3% each). Identified etiologies of AP included autoimmune causes (20%) and severe hypertriglyceridemia (10%). In 70% of cases, the underlying mechanism remained undetermined. Despite a favorable outcome after the first episode, AP recurrence was common in T1D patients, with a recurrence rate of 16.7%.
Discussion: The pathophysiological mechanism of AP in T1D patients remains poorly understood. The impact of AP on pancreatic tissue, already weakened by autoimmune destruction in T1D, may be more pronounced compared to non-diabetic individuals. Our study highlights an increased incidence of stage E AP and a higher recurrence rate in this population. Further studies with larger sample sizes are needed to provide more precise explanations.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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