Endocrine Abstracts

JOINT3842

Introduction: Acromegaly is a rare condition secondary to hypersecretion of GH often by a pituitary adenoma. High blood pressure is frequently found, aggravating the cardiovascular complications of acromegaly and improving its risks of morbidity and mortality. The objective Is to specify the frequency and evaluate the clinical and paraclinical characteristics of High blood pressure in acromegalic patients.

Patients and methods: This is a retrospective, descriptive study of 78 patients hospitalized in the endocrinology, diabetology and metabolic diseases department of Ibn-Rochd University Hospital, Casablanca from January 2007 to December 2024.

Results: Elevated blood pressure – hypertension was found in 27 cases (21%), with a mean age of 54 years (36–72) and a sex ratio: F/M of 2.45. Mean blood pressure was 150/90 mmHg. Grade 1 was found in 51%, grade 2 in 34% and grade 3 in 15%. Hypertension was well controlled in 58% under monotherapy and in 32% under dual therapy. Hypertension was resistant in 22% under dual therapy and in 12% under triple therapy and was associated with diabetes or prediabetes in 79% of cases, and with dyslipidemia in 52%. Hypertensive retinopathy was found in 38% of cases, positive microalbuminuria (42%) and hypertensive heart disease (19%). Hypertension did not regress in any patient after surgical management.

Conclusion: In a third of cases, high blood pressure is found and is an integral part of the cardiovascular complications that determine cardiovascular morbidity and mortality.