Acromegaly and kidney cancer what is the link?

Chayma Zouna; Ikrame Qasdi; Hasna Ouirar; Zineb Habbadi; Fatima Toulali; Ghizlane Sabbar; Kaoutar Rifai; Hind Iraqi; Gharbi Mohamed Hassan

doi:10.1530/endoabs.110.EP1283

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Endocrine Abstracts (2025) 110 EP1283 | DOI: 10.1530/endoabs.110.EP1283

ECEESPE2025 ePoster Presentations Pituitary, Neuroendocrinology and Puberty (220 abstracts)

Acromegaly and kidney cancer what is the link?

Chayma Zouna ¹ , Ikrame Qasdi ¹ , Hasna Ouirar ¹ , Zineb Habbadi ¹ , Fatima Toulali ¹ , Ghizlane Sabbar ¹ , Kaoutar Rifai ¹ , Hind Iraqi ¹ & Mohamed Hassan Gharbi ¹

Author affiliations

¹CHU Rabat, Endocrinologie, Rabat, Morocco

JOINT2580

Introduction: Acromegaly is a chronic disease associated with an increased risk of cancer. A recent survey study conducted in Italy demonstrated an increased incidence of all malignant tumors in acromegalic patients, as well as gender differences in the incidence of malignant tumor types, with an increased incidence of thyroid, colorectal and breast cancer in women, while thyroid, kidney and colorectal cancer in men.

Observation: 73-year-old patient with history of Enucleation for papillary renal carcinoma in 2013. Diagnosed in our training for Acromegaly clinically confirmed by dysmorphic syndrome acro-facial biologically IGF1 rate elevated to 2.6N with morphologically a hypotalamo-hypophyseal MRI in favor of a left paramedian pituitary micro-adenoma. Acromegaly: severe obstructive sleep apnea syndrome. 28-year history of hypertension complicated by non-sequelae ischemic stroke on dual therapy. Diabetes for 02 years on Metformin. Colonoscopy: presence of a histologically resected pedunculated polyp compatible with a tubulovillous adenoma with low-grade dysplasia. The patient was referred to neurosurgery for transphenoidal removal of the adenoma.

Discussion: IGF-1 synthesized locally in connective tissue adjacent to renal epithelial cells acts as a paracrine or autocrine factor in the kidney. The degree of IGF1R gene expression is different throughout the nephrogenic zone, with stronger expression in glomeruli and tubular epithelium of the medulla, and weaker expression in proximal tubules [12]. IGF1R affects the transformation of renal cells to malignancy by inducing cell proliferation, dedifferentiation and inhibiting apoptosis. RCC cells are sensitive to exogenous IGF-1 stimulation. Expression of IGF1R and the development of ccRCC were found to be associated, indicating that it may be a possible molecular prognostic marker as well as a potential target for new therapeutic interventions. Therefore, treatment of acromegaly and control of disease progression in acromegalic patients with any type of cancer are mandatory.