Long term pubertal outcome of patients with prenatal diagnosis of ovarian cysts

Yannis Bonnin; Sarah Garnier; Marie-Pierre Guibal; Eric Dobremez; Aurelie Cazals; Benoit Tessier; Servant Nadege Fauconnet; Najiba Lahlou; Charles Sultan; Francoise Paris; Nicolas Kalfa

doi:10.1530/endoabs.110.EP1304

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Endocrine Abstracts (2025) 110 EP1304 | DOI: 10.1530/endoabs.110.EP1304

ECEESPE2025 ePoster Presentations Reproductive and Developmental Endocrinology (128 abstracts)

Long term pubertal outcome of patients with prenatal diagnosis of ovarian cysts

Yannis Bonnin ¹ , Sarah Garnier ¹ , Marie-Pierre Guibal ¹ , Eric Dobremez ² , Aurélie Cazals ¹ , Benoit Tessier ¹ , Nadège Fauconnet Servant ¹ , Najiba Lahlou ³ , Charles Sultan ¹ , Francoise Paris ¹ & Nicolas Kalfa ¹

Author affiliations

¹Hôpital Lapeyronie, CHU Montpellier, Montpellier, France; ²Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France; ³Laboratoire BPR-AS, PANNES, France

JOINT1708

Prenatal ovarian cysts (POC) require close postnatal follow-up and sometimes surgery in case of complications. Long-term outcome and pubertal development have not been reported in these patients and would be useful to rationalize treatment, follow-up and parental counselling. This study aims to compare pubertal development and plasmatic AMH level of patients with POC compared to healthy controls. This prospective case-control study included patients with diagnosis of POC and healthy controls without endocrine disease. Each child underwent a clinical evaluation of pubertal development (Tanner stages, age of onset), a dosage of plasmatic AMH, LH and FSH. Early puberty was defined as thelarche before 9y and late as after 13y. 105 children were included (56 cases). Mean age was 13.8 yearsd. Mean ages of thelarche (10.85 vs 11.04, P = 0.630), pubarche (10.96 vs 11.03, P = 0.860) and menarche (12.4 vs 12.23, P = 0.845) were not different between cases and controls. Neither early (4 vs 2, P = 0.643) nor late (2 vs 7, P = 0.080) puberty was more frequent in case of POC. Plasmatic AMH was comparable between cases and controls (36.75 vs 39.90, P = 0.742), FSH and LH concentrations were not increased in cases (FSH:4.43 vs 3.87, P = 0.31; LH: 4.05 vs 3.37, P = 0.38), even in ovariectomy group (FSH:4.7 vs 3.94, P = 0.23; LH:4.17 vs 3.45, P = 0.22). Patients with POC develop a normal puberty and have levels of plasmatic AMH and gonadotropic hormones similar to controls. These data are reassuring for the pubertal outcome of these patients and that may alleviate their follow-up, at least for those without ovariectomy.