Endocrine Abstracts

JOINT1059

Growth hormone (GH) occupies a pivotal role in human growth and development. It not only promotes linear growth but also exerts profound influences on bone metabolism, bone dimensions, and bone mineral density (BMD) in pediatric and adolescent populations through the modulation of bone formation and resorption processes. Notably, the impact of GH on spinal growth has garnered considerable attention. Scoliosis, a complex three-dimensional spinal deformity characterized by lateral curvature of one or more vertebral segments, often accompanied by vertebral rotation and sagittal plane imbalance, poses a significant challenge. Among patients with growth hormone deficiency (GHD), the question of whether GH supplementation may contribute to the onset or progression of scoliosis remains a subject of debate. Recently, numerous scholars have conducted extensive research to explore the relationship between recombinant human growth hormone (rhGH) replacement therapy and scoliosis, yielding a range of findings, some of which are contradictory. This study aims to conduct an in-depth exploration of the effects of GH on spinal growth and to provide a comprehensive analysis of the potential association between rhGH replacement therapy and scoliosis. To achieve this, we will comprehensively review the impacts of GH and insulin-like growth factor 1 (IGF-1) on bone metabolism and bone mass, while also examining the consequences of GHD on bone health. By meticulously synthesizing existing research findings, we seek to elucidate with greater clarity the mechanisms through which GH regulates spinal growth and maintains spinal morphology. Furthermore, this study will specifically focus on the impact of rhGH replacement therapy on adolescent idiopathic scoliosis (AIS), with the objective of providing novel insights and guidance for the prevention and management of this condition. Through this comprehensive examination, we aspire to offer more refined diagnostic and treatment recommendations for patients with GHD and scoliosis.