Screening for dysthyroidism in pregnant women with diabetes

Ramla Mizouri; Othman Rym Ben; Rim Rachdi; Faten Mahjoub; Olfa Berriche; Amor Nadia Ben; Jamoussi Henda

doi:10.1530/endoabs.110.EP1613

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Endocrine Abstracts (2025) 110 EP1613 | DOI: 10.1530/endoabs.110.EP1613

ECEESPE2025 ePoster Presentations Thyroid (198 abstracts)

Screening for dysthyroidism in pregnant women with diabetes

Ramla Mizouri ¹ , Rym Ben Othman ¹ , Rim Rachdi ¹ , Faten Mahjoub ² , Olfa Berriche ¹ , Nadia Ben Amor ² & Jamoussi Henda ¹

Author affiliations

¹Institut National de Nutrition de Tunis, Service A, Tunis, Tunisia; ²Institut National de Nutrition de Tunis, Tunis, Tunisia

JOINT3991

Introduction: Pregnancy is accompanied by physiological changes that affect the functioning of the thyroid gland. These changes put pregnant women at increased risk of dysthyroidism. The objective of this study was to screen for dysthyroidism in pregnant diabetic women.

Methods: This is a descriptive study carried out on 50 diabetic pregnant women. The diagnosis of hypothyroidism is made at a TSH level greater than 2.5 μmol/l in the first trimester, and 3 μmol/l in the second and third trimesters.

Results: The average age of the patients was 33 years. Pregnancy was planned in 38% of cases, 84% of whom had controlled diabetes during hospitalization (average HBA1c of 6.33%). The average duration of progression of diabetes was 9 years. Forty-eight percent of pregnant women had type 1 diabetes. The average cholesterol level was 4.84 mmol/l. The mean FT4 level was 9.45 pmol/l and the mean TSH level was 2.1 μmol/l. The diagnosis of hypothyroidism was made in 22% of the population studied at an average term of 9 weeks of amenorrhea. All of these patients had type 1 diabetes. The patients were placed on a dose of 25 mg/day. Only two of them required an increase in the dose to 50 mg/day. No cases of hyperthyroidism were found.

Conclusion: Pregnancy planning in diabetic women is imperative. It is essential to systematically include a thyroid assessment in order to detect dysthyroidism and its fetal complications early.