ECEESPE2025 Poster Presentations Environmental Endocrinology (20 abstracts)
Sex-specific associations between maternal and postnatal exposure to bisphenol a (BPA) and children’s body mass index: a prospective cohort study
Youn-Hee Lim 1 , Yun-Chul Hong 2 , Yun Jeong Lee 3 , Choong Ho Shin 3 , Dongwook Lee 4 , Bung-Nyun Kim 5 , Johanna Kim 6 & Young Ah Lee 3
1University of Copenhagen, Public Health, Copenhagen, Denmark; 2Seoul National University College of Medicine, Seoul, South Korea; 3Seoul National University Children’s Hospital, Seoul, South Korea; 4Inha University Hospital, Incheon, South Korea; 5Seoul National University Hospital, Seoul, South Korea; 6Hanyang University Medical Center, Seoul, South Korea
JOINT1610
Background: Exposure to bisphenol A (BPA) may affect the weight of exposed individuals and/or offspring, while the influence of BPA on obesity by sex remains controversial. Aim To investigate sex-specific associations between maternal and postnatal exposure to BPA and children’s body mass index (BMI) in a prospective cohort study of 592 mother-child pairs.
Methods: We used data from the Environment and Development of Children study, a prospective birth cohort study in South Korea. We assessed BPA concentration levels in mid-term pregnant women and their children, aged 2 to 10 years, to evaluate the age- and sex-specific associations with children’s BMI and BMI Z-scores (BMI-Z) in linear regression models and sex-specific associations across years in mixed models after adjusting for potential confounders.
Results: We observed an increased BMI or BMI-Z in boys but decreases in girls associated with maternal exposure to BPA. While the difference in BMI was pronounced at age 10, standardized BMI-Z showed consistently significant sex differences at all ages. Postnatal exposure to BPA was negatively associated with BMI and BMI-Z at ages 2 and 10, but we did find significant differences by sex.
Conclusion: Findings from this prospective study support the assertion that maternal BPA levels have sex-dimorphic effects on childhood BMI.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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