Endocrine Abstracts

JOINT59

Background: Gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard to identify central precocious puberty (CPP). However, intravenous GnRH for testing is commercially limited. The aim of the present study was to evaluate the diagnostic accuracy of triptorelin-stimulated luteinizing hormone (LH) concentrations in the diagnosis of CPP among girls presenting with premature thelarche (PT) compared to the gold standard GnRH test.

Methods: A retrospective study of 186 girls with sexual precocity was undertaken. All girls underwent subcutaneous triptorelin injection. Blood samples before and 30, 60, 90 and 120 min after the injection were analyzed for LH and follicle-stimulating hormone (FSH) levels. Girls with peak triptorelin-stimulated LH concentrations ≥5. 0 IU/l were classified as having CPP. Results Eighty-eight patients (47. 3%) were classified as CPP and the rest (98 out of 186, 52. 7%) as PT. The peak LH was achieved at 60 minutes after triptorelin-stimulation in CPP groups, but 120 minutes in PT groups. On cross-sectional frequency, ninety-three percent of CPP group patients were diagnosed CPP with LH levels of ≥5 IU/l at 90 min and 120 min, each. The cumulative frequency of LH ≥5 IU/l was 90. 9% at 60 minutes, 95. 5% at 90 minutes, and 100% at 120 minutes. Conclusions Subcutaneous triptorelin can be used as an alternative to confirm the diagnosis of CPP. We tried to propose shorter duration of subcutaneous triptorelin-stimulation test for diagnosing CPP. The peak LH showed at 60 minutes after injection in CPP group, but the cumulative frequency of LH ≥5 IU/l was 100% at 120 minutes. Not to miss one single CPP patient, it is necessary for 120 minutes full examination.