Endocrine Abstracts

JOINT1136

Introduction: This abstract explores the complex relationship between IR, BMI, free testosterone and estradiol levels in male adults and adolescents, highlighting the bidirectional influences that exacerbate metabolic and hormonal dis-regulation. Insulin resistance is linked to low free testosterone levels due to increased inflammation, weight gain (especially visceral fat) and impaired function of the hypothalamic-pituitary-gonadal axis. Visceral fat leads to more aromatase activity, converting testosterone into estradiol, which lowers testosterone levels further. Chronic hyperinsulinemia suppresses luteinizing hormone (LH), reducing the production of testosterone in the testes.

Objectives: The aim of this study was to analyze the association between Insulin resistance, BMI, Free testosterone and estradiol levels in male adults and adolescents.

Material and Methods: Cross-sectional study of 26 male patients from 13 to 44 years Including criteria were. Insulin resistance >2.27 and BMI >25 kg/m² Patients were divided into two age groups: A). 13-18 years (12 patients) and B). 19-44 years (14 patients) Free Testosterone deficiency was defined as levels < 15 pg/ml in adults and <12.3 pg/ml in adolescents or excess estradiol levels more then 43 pg/ml in adults and >23 pg/ml in adolescents. In group A the studied population had a mean age of 15, mean HOMA -IR of 5.07, mean BMI - 33.2 In group B the studied population had a mean age of 30.5 and mean HOMA -IR of 6.4,. mean BMI- 35.

Results: Free Testosterone deficiency prevalence was 35.7 % in adults and 16.7 % in adolescents, while high estradiol prevalence were respectively 50 %(adults) and 25 %(adolescents) in groups, BMI values were 33. ±10.5 (A) and 35 ±10.5(B).

Conclusions: Our small study suggests a interplay between insulin resistance, low testosterone and high estradiol levels. The findings indicate that hormonal imbalances may contribute to worsening metabolic dysfunction, highlighting the importance of addressing both insulin sensitivity and hormone levels in treatment strategies. Further large-scale studies are needed to confirm these results and develop effective therapeutic approaches for mitigating associated health risks.